Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

APCS (P02743) - Overview - Molecular Target Synopsis

Protein


APCS, Serum amyloid P-component
UniProt P02743

Also Known as SAMP_HUMAN, APCS, PTX2

Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells. May also function as a calcium-dependent lectin. Homopentamer. Pentraxin (or pentaxin) have a discoid arrangement of 5 non-covalently bound subunits.

4AYU
STRUCTURE OF N-ACETYL-D-PROLINE BOUND TO SERUM AMYLOID P COMPONENT
RCSB/PDB
Inspect Structure
See all 3D Structures for APCS

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
223ENSG00000132703ENST00000255040ENSP00000255040P02743-1

Sub-cellular localization


UniProt: APCS is active in the following subcellular-locations: secreted.
GO terms: APCS is active in the following subcellular-locations: blood microparticle, collagen-containing extracellular matrix, extracellular exosome, extracellular region, extracellular space, nucleus.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project APCS has gain in 4 cell-lines, loss in 0 cell-lines and no signal in 1001 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: MCF7, NCI_H460, LOXIMVI

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: PLC/PRF/5, RMG-I, NCI-H1395

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HSMM

(see details)

3D Structures


For APCS there are:
13 structures (90 chains) solved
12 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


APCS has been screened with 18 compounds (232 bioactivities). (see details)