Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

Rbp1 (P02696) - Overview - Molecular Target Synopsis

Protein


Rbp1, Retinol-binding protein 1
UniProt P02696

Also Known as RET1_RAT, Rbp1, Rbp-1

Cytoplasmic retinol-binding protein (PubMed:7683727, PubMed:12850148). Accepts retinol from the transport protein STRA6, and thereby contributes to retinol uptake, storage and retinoid homeostasis (By similarity). Interacts (only as retinol-free apoprotein) with STRA6.

1MX8
TWO HOMOLOGOUS RAT CELLULAR RETINOL-BINDING PROTEINS DIFFER IN LOCAL STRUCTURE AND FLEXIBILITY
RCSB/PDB
Inspect Structure
See all 3D Structures for Rbp1

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
135P02696-1

Sub-cellular localization


UniProt: Rbp1 is active in the following subcellular-locations: cytoplasm, lipid droplet.
GO terms: Rbp1 is active in the following subcellular-locations: cell body, cytosol, lipid droplet, nucleoplasm.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project Rbp1 has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For Rbp1 there are:
5 structures (5 chains) solved
3 are solved in complex with at least one small molecule ligand
3 are solved with an approved drug

Rbp1 is solved in complex with the approved drug(s):

RTL/RETINOL (1CRB_A, 1KGL_A, 1MX8_A).

(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


Rbp1 has been screened with compounds ( bioactivities). (see details)