Molecular Target Synopsis
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PMP2 (P02689) - Druggability - Molecular Target Synopsis

Chain-based assessment (last updated 14/05/2019)
Domain-based assessment (last updated 30/07/2012)


Structural Druggability Help: Help

Chain-based assessment (last updated 14/05/2019)


Chains assessed22
Chains with at least one site assessed as druggable using the strict criteria22
Chains with at least one site assessed as druggable using the relaxed criteria22


		
PDB Chain Protein Name Druggable Relaxed Druggable Strict Details
3NR3_A Myelin P2 protein Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.55 99.3 0 Yes Yes
2 empty 2.12 55.9 21.7 No No
3 bound 1.94 70.4 10.9 No No
4 empty 2.38 64.1 17.1 No No
5 empty 2.26 65.5 10.9 No No
6 bound 2.08 72.3 7.8 No No
7 empty 2.41 53.5 12.4 No No
8 bound 2.7 62.2 10.9 No No
9 empty 2.13 67.7 11.1 No No
10 empty 1.92 53.6 10.1 No No
4A1Y_A Myelin P2 protein Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.56 88.6 22.3 Yes Yes
2 empty 2.29 62.2 17.7 No No
3 empty 2.64 64.4 18.5 No No
4 empty 2.12 67.1 10.8 No No
5 empty 1.92 59.9 16.4 No No
6 empty 2.36 57.8 14 No No
7 empty 2.62 65.9 17 No No
8 empty 2.22 72.3 8.6 No No
9 empty 1.88 64.6 8.4 No No
10 empty 2.3 66.1 8.9 No No
6EW5_C Myelin P2 protein Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.56 98.5 0 Yes Yes
2 empty 2.41 64.5 21.1 No No
3 empty 1.93 62.5 15.4 No No
4 empty 2.31 68.3 13.1 No No
5 empty 2.31 57.5 14.8 No No
6 empty 2.24 68.3 10 No No
7 empty 2.1 64.6 11.7 No No
8 empty 2.54 60.8 12.7 No No
9 empty 2.53 63.8 12.4 No No
10 empty 2.1 62.4 10.7 No No
4A8Z_A Myelin P2 protein Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.55 98.8 0 Yes Yes
2 empty 2.45 63.8 18.2 No No
3 empty 2.64 64.7 16.2 No No
4 empty 2.55 71 11.8 No No
5 bound 2.16 65.6 12.1 No No
6 bound 2.33 63.5 19.1 No No
7 empty 2.09 70.3 9.6 No No
8 empty 2.34 62.4 18.7 No No
9 empty 2.29 68 11.5 No No
10 empty 2.68 57.6 14.7 No No
4A1Y_C Myelin P2 protein Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.55 78.9 30.5 Yes Yes
2 empty 2.28 60.8 19.8 No No
3 empty 2.05 72.9 10.1 No No
4 empty 2.04 66.6 11.5 No No
5 empty 2.61 66.7 17.3 No No
6 empty 2.24 67.4 10.7 No No
7 empty 2.34 61.3 11 No No
8 empty 2.53 67.3 15.2 No No
9 empty 2.14 74.1 9.8 No No
10 empty 2.6 66.7 7.5 No No
5N4P_A Myelin P2 protein Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.56 99.5 0 Yes Yes
2 empty 2.3 59.5 19 No No
3 empty 2.41 64.6 24.7 No No
4 empty 2.67 61.8 17.7 No No
5 bound 2.13 69.2 10.6 No No
6 empty 2.46 67.3 15.1 No No
7 empty 2.1 58 11.2 No No
8 empty 2.16 67.9 9.9 No No
9 empty 1.96 57.5 9.3 No No
10 empty 2.51 62.2 13.7 No No
5N4M_A Myelin P2 protein Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.56 99.3 0 Yes Yes
2 empty 2.44 65.1 26.2 No No
3 empty 2.47 63.7 25.4 No No
4 empty 2.69 59.3 17.3 No No
5 bound 2.14 69.6 10.8 No No
6 empty 2.22 64.6 10.9 No No
7 empty 2 61 10.1 No No
8 empty 2.31 69.5 11.4 No No
9 empty 2.74 64.5 9.4 No No
10 empty 2.54 63.6 14 No No
6EW2_A Myelin P2 protein Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.51 99.1 0 Yes Yes
2 empty 2.39 64 25.3 No No
3 empty 2.33 61.5 17.1 No No
4 empty 2.19 70.9 12.3 No No
5 empty 2.44 62.8 12.8 No No
6 empty 1.91 64 10.6 No No
7 empty 2.29 64.7 10.3 No No
8 empty 2.38 68.2 13.9 No No
9 empty 2.4 71.8 11.3 No No
10 empty 2.21 57.1 13.7 No No
6EW5_A Myelin P2 protein Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.47 88.8 20.7 Yes Yes
2 empty 2.38 63 25.9 No No
3 empty 2.14 67 14.4 No No
4 empty 2.4 70.6 11.9 No No
5 empty 1.92 68.3 10.3 No No
6 empty 2.22 66.8 10.2 No No
7 empty 2.63 64.9 15.6 No No
8 empty 2.65 69.3 10.1 No No
9 empty 2.51 62.2 17.6 No No
10 empty 2.36 67 11.1 No No
4A1H_A Myelin P2 protein Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.67 99.3 0 Yes Yes
2 empty 2.38 61.9 20.7 No No
3 empty 2.34 64 17 No No
4 empty 2.82 63.1 21.9 No No
5 empty 2.28 69.3 9.9 No No
6 empty 2.12 67.7 9.9 No No
7 empty 2.6 64.1 11.5 No No
8 empty 2.27 59.1 11.1 No No
9 empty 2.5 61.6 13.9 No No
10 empty 2.61 63 12.5 No No
4A1H_B Myelin P2 protein Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.49 99.1 0 Yes Yes
2 empty 2.5 58.6 20.6 No No
3 empty 1.96 65.5 10.3 No No
4 empty 2.47 59.5 15.8 No No
5 empty 2.23 65.3 9.7 No No
6 empty 2.5 63.7 9.4 No No
7 empty 2.1 72.4 8.6 No No
8 empty 2.21 64 13.5 No No
9 empty 2.36 66.4 9.4 No No
10 empty 2.27 66.2 12.8 No No
6EW5_D Myelin P2 protein Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.51 99.5 0 Yes Yes
2 empty 2.28 60.8 16.7 No No
3 empty 2.04 66.7 18.3 No No
4 empty 1.96 65.4 12.5 No No
5 empty 2.57 64.6 18 No No
6 empty 2.3 67.2 9.8 No No
7 empty 2.32 73.6 9.1 No No
8 empty 2.67 64.3 14.9 No No
9 empty 2.53 70.4 8.1 No No
10 empty 2.3 64.3 8.8 No No
4BVM_A Myelin P2 protein Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.54 99.8 0 Yes Yes
2 empty 2.24 57.4 26.7 No No
3 empty 2.42 62.9 25.9 No No
4 empty 2.1 68.5 10.6 No No
5 bound 1.99 70.8 10.8 No No
6 empty 2.25 70.8 8.9 No No
7 empty 2.43 63 11.1 No No
8 empty 2.4 60.7 9.3 No No
9 empty 2.59 67 10.3 No No
10 empty 2.36 65 7.2 No No
4A1Y_D Myelin P2 protein Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.57 82.7 31.2 Yes Yes
2 empty 2.24 61.9 27.9 No No
3 empty 1.83 63.9 11.8 No No
4 empty 2.13 76.4 9.8 No No
5 empty 2.6 64.7 16.1 No No
6 empty 2.63 70.9 11.7 No No
7 empty 2.33 63.4 14.6 No No
8 empty 2.54 66.4 7 No No
9 empty 2.61 66.1 8.4 No No
10 empty 1.72 60.2 9.4 No No
5N4Q_A Myelin P2 protein Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.56 99.5 0 Yes Yes
2 empty 2.26 58 27.1 No No
3 empty 2.58 61.8 17.9 No No
4 empty 2.47 63.3 16.6 No No
5 bound 2.11 65 10.7 No No
6 empty 2.03 63.2 10.5 No No
7 empty 2.38 65.3 14.9 No No
8 empty 2.32 65.6 10.1 No No
9 empty 2.36 66.8 9.3 No No
10 empty 2.3 66.4 12.8 No No
4D6B_A Myelin P2 protein Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.72 98.4 0 Yes Yes
2 empty 2.4 57.9 29 No No
3 bound 2.35 62.2 20.4 No No
4 empty 2.57 63.3 16.8 No No
5 empty 1.96 61.8 11.2 No No
6 empty 2.49 67.9 7.9 No No
7 bound 2.2 67.5 12.2 No No
8 empty 2.13 67.3 9.8 No No
9 empty 2.35 68.2 10 No No
10 empty 2.51 69.4 8.5 No No
6EW4_A Myelin P2 protein Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.54 86.1 22.7 Yes Yes
2 empty 2.53 63.9 22.4 No No
3 empty 2.31 63.4 19.9 No No
4 empty 2.52 62.7 16.9 No No
5 empty 1.77 58.8 15.6 No No
6 empty 1.97 67 10.2 No No
7 empty 2.33 63.3 10.7 No No
8 empty 2.24 58 12.3 No No
9 empty 2.54 76.1 7.3 No No
10 empty 2.53 59.2 9.2 No No
6EW5_B Myelin P2 protein Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.53 98.2 0 Yes Yes
2 empty 2.58 60.1 17.8 No No
3 empty 2.08 65.3 12 No No
4 empty 1.71 58.4 16.8 No No
5 empty 2.64 62.2 17.6 No No
6 empty 2.24 65.7 10.2 No No
7 empty 2.68 61.1 13.5 No No
8 empty 2.44 64.7 12.8 No No
9 empty 2.36 68.9 10 No No
10 empty 2.21 69.8 8.7 No No
4A1Y_B Myelin P2 protein Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.55 78.1 31.4 Yes Yes
2 empty 2.63 63.3 21.7 No No
3 empty 2.25 61.8 20 No No
4 empty 2.07 67.9 11.4 No No
5 empty 2.08 65.9 10 No No
6 empty 2.15 61.4 11.6 No No
7 empty 2.11 69.8 11.8 No No
8 empty 2.21 66.5 7.1 No No
9 empty 2.71 61.9 8.7 No No
10 empty 2.61 52.4 7.1 No No
4A1H_C Myelin P2 protein Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.51 86 24.5 Yes Yes
2 empty 2.45 65.4 35.9 No No
3 empty 2.68 62.5 16.1 No No
4 empty 2.3 66.4 12.7 No No
5 empty 2.31 71.9 14.2 No No
6 empty 2.18 65.6 7 No No
7 empty 2.24 70.3 7.8 No No
8 empty 2.32 63.4 6.5 No No
9 empty 2.21 63.3 10.7 No No
10 empty 2.3 58.7 8 No No
4D6A_A Myelin P2 protein Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.54 98.5 0 Yes Yes
2 empty 2.21 60.8 27.3 No No
3 empty 2.7 57.6 19.7 No No
4 empty 2.47 62.7 16.5 No No
5 bound 2.01 73.6 10.4 No No
6 empty 1.96 64.6 11.3 No No
7 empty 2.32 64.7 14.6 No No
8 empty 2.34 65.2 10.1 No No
9 empty 2.28 74.6 7.6 No No
10 empty 2.42 56.7 9.5 No No
2WUT_A Myelin P2 protein Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.56 99.2 0 Yes Yes
2 empty 2.43 62.1 23 No No
3 empty 2.41 64.4 22.8 No No
4 empty 2.47 63.6 14.8 No No
5 empty 2.11 66.6 12.7 No No
6 empty 2.06 65.1 11.3 No No
7 empty 2.27 67.8 9.7 No No
8 empty 2.16 71.1 12.2 No No
9 empty 2.39 74.7 7.9 No No
10 empty 2.28 65.9 7.4 No No

Domain-based assessment (last updated 30/07/2012)


Domains assessed2
Domains assessed as druggable using the strict criteria2
Domains assessed as druggable using the relaxed criteria2

PDB (Domain) Protein Name Domain Resolution Ligands Druggable Relaxed Druggable Strict
2WUT_A (3250887) Myelin P2 protein Lipocalins, Lipocalins, Fatty acid binding protein-like 1.85Å Yes Yes
3NR3_A (3560949) Myelin P2 protein Lipocalins, Lipocalins, Fatty acid binding protein-like 1.95Å Yes Yes
Ligand-based Druggability Score: 0.05
Ligand-based Druggability Score Percentile: 80%
Ligand-based Druggability Help: Help




		
Number of proteins in the network : 13346


PMP2 is involved in 1 interactions in the network.


Druggability
Overall Druggability Percentile: 7.96
Druggability for Cancer Therapeutics: 3.93
Druggability for Other Therapeutics: 6.11
Cancer-Associated
Cancer-associated percentile : 3.71
Network Articulation Point
Is PMP2 critical for communication in the network?


Detailed Graph Legend:Help