Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

PMP2 (P02689) - Overview - Molecular Target Synopsis

Protein


PMP2, Myelin P2 protein
UniProt P02689

Also Known as MYP2_HUMAN, PMP2

May play a role in lipid transport protein in Schwann cells. May bind cholesterol. Monomer.

6EW5
HUMAN MYELIN PROTEIN P2 F57A MUTANT, MONOCLINIC CRYSTAL FORM
RCSB/PDB
Inspect Structure
See all 3D Structures for PMP2

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
132ENSG00000147588ENST00000256103ENSP00000256103P02689-1
60ENSG00000147588ENST00000519260ENSP00000429917

Sub-cellular localization


UniProt: PMP2 is active in the following subcellular-locations: cytoplasm.
GO terms: PMP2 is active in the following subcellular-locations: cytoplasm, extracellular exosome, myelin sheath.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project PMP2 has gain in 18 cell-lines, loss in 2 cell-lines and no signal in 985 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: MALME_3M, SK_MEL_28, SK_MEL_2

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: COLO 857, COLO 699, 928 mel

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HSMM

(see details)

3D Structures


For PMP2 there are:
14 structures (22 chains) solved
14 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


PMP2 has been screened with compounds ( bioactivities). (see details)