Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

MBP (P02686) - Overview - Molecular Target Synopsis

Protein


MBP, Myelin basic protein
UniProt P02686

Also Known as MBP_HUMAN, MBP

The classic group of MBP isoforms (isoform 4-isoform 14) are with PLP the most abundant protein components of the myelin membrane in the CNS. They have a role in both its formation and stabilization. The smaller isoforms might have an important role in remyelination of denuded axons in multiple sclerosis. The non-classic group of MBP isoforms (isoform 1-isoform 3/Golli-MBPs) may preferentially have a role in the early developing brain long before myelination, maybe as components of transcriptional complexes, and may also be involved in signaling pathways in T-cells and neural cells. Differential splicing events combined with optional post-translational modifications give a wide spectrum of isomers, with each of them potentially having a specialized function. Induces T-cell proliferation. Homodimer. Isoform 3 exists as a homodimer.

1ZGL
14 RESIDUE FRAGMENT OF
MYELIN BASIC PROTEIN
IN THE STRUCTURE OF
CRYSTAL STRUCTURE OF 3A6 TCR BOUND TO MBP/HLA-DR2A
RCSB/PDB
Inspect Structure
See all 3D Structures for MBP

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: MBP is active in the following subcellular-locations: myelin membrane, nucleus.
GO terms: MBP is active in the following subcellular-locations: cell periphery, cell surface, compact myelin, internode region of axon, intracellular, myelin sheath, neuronal cell body, nucleus, plasma membrane, protein-containing complex.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project MBP has gain in 2 cell-lines, loss in 20 cell-lines and no signal in 983 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: MALME_3M, SK_MEL_28, UACC_257

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: SK23, SK-MEL-28, DEOC-1

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: NHEK, SK-N-SH, NHLF

(see details)

3D Structures


For MBP there are:
7 structures (12 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


MBP has been screened with compounds ( bioactivities). (see details)