Molecular Target Synopsis
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RNAi
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FGG (P02679) - Druggability - Molecular Target Synopsis

Chain-based assessment (last updated 07/05/2019)
Domain-based assessment (last updated 30/07/2012)


Structural Druggability Help: Help

Chain-based assessment (last updated 07/05/2019)


Chains assessed76
Chains with at least one site assessed as druggable using the strict criteria6
Chains with at least one site assessed as druggable using the relaxed criteria54


		
PDB Chain Protein Name Druggable Relaxed Druggable Strict Details
1RE3_C Fibrinogen gamma chain No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.11 70.1 18.5 No No
2 empty 2.2 61 24.8 No No
3 empty 1.83 64.3 18.9 No No
4 empty 2.45 51.9 17.2 No No
5 empty 2.26 69.1 14.2 No No
6 empty 2.13 66.7 20.6 No No
7 empty 2.36 57.1 18.4 No No
8 empty 2.08 64.4 18.4 No No
9 empty 2.1 77 8.7 No No
10 empty 2.66 61.3 11.7 No No
2Z4E_F Fibrinogen gamma chain Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.19 72.9 17.1 Yes No
2 empty 2.15 62.2 18.3 No No
3 empty 2.29 68.8 16.9 No No
4 empty 1.75 64.9 18.1 No No
5 empty 2.29 52.6 16.6 No No
6 empty 2.18 70.7 10.8 No No
7 empty 2.17 57.8 19.9 No No
8 empty 2.05 57.3 11.9 No No
9 empty 2.62 57.6 17.3 No No
10 empty 2.07 75.5 7.4 No No
2HPC_I Fibrinogen gamma chain Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.18 71.3 17.8 Yes No
2 empty 2.25 50.6 19 No No
3 empty 2.09 67.6 14.1 No No
4 empty 1.82 66.4 17.6 No No
5 empty 1.99 68 12.8 No No
6 empty 2.3 64 12.8 No No
7 empty 1.96 69.4 13.6 No No
8 empty 1.43 53.1 15.4 No No
9 empty 2.06 76 9.8 No No
10 empty 2.23 79.5 9.5 No No
3H32_C Fibrinogen gamma chain Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.98 51.8 26.3 Yes No
2 empty 1.99 63.2 26.3 No No
3 empty 2.31 66.2 20.3 No No
4 empty 1.84 67.2 15.5 No No
5 empty 1.81 66.9 16.1 No No
6 empty 2.17 70.8 14.6 No No
7 empty 2.3 61.8 13.3 No No
8 empty 2.21 75.4 9.8 No No
9 empty 2.26 70.2 15.2 No No
10 empty 2.49 61.6 9.3 No No
1RE3_F Fibrinogen gamma chain Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.33 74.4 18.7 Yes No
2 empty 1.9 59 27.9 No No
3 empty 2.28 65.8 21 No No
4 empty 2.16 68.5 15.4 No No
5 empty 2.3 72.3 9 No No
6 empty 2.11 51.6 12.8 No No
7 empty 2.43 53.6 11.2 No No
8 empty 2.52 64.8 11.9 No No
9 empty 2.37 79.1 8 No No
10 empty 2.09 64.5 14.2 No No
2HOD_L Fibrinogen gamma chain Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.92 76.5 16.8 Yes No
2 empty 2.27 65.9 16.9 No No
3 empty 1.81 60.9 17.9 No No
4 empty 2.19 71.1 20.7 No No
5 empty 2.26 65.4 13.2 No No
6 empty 2.28 65.9 21.3 No No
7 empty 2.34 57.8 16.5 No No
8 empty 2.14 74.3 9.5 No No
9 empty 2.45 54.4 17.6 No No
10 empty 2.08 77 9.5 No No
1FIC_A Fibrinogen gamma chain Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.52 64.2 40 Yes No
2 empty 2.14 68.3 26.6 No No
3 empty 2.28 63.5 14.3 No No
4 empty 1.99 62.9 18.3 No No
5 empty 2.06 64.6 15 No No
6 empty 2.41 62.8 9.1 No No
7 empty 2.51 56.4 10.8 No No
8 empty 1.97 55.6 8.8 No No
9 empty 1.95 74.7 7.6 No No
10 empty 1.97 65.6 8.5 No No
2OYH_F Fibrinogen gamma chain Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.99 72.7 16.5 Yes No
2 empty 2.41 62.2 21.9 No No
3 empty 2.2 64.3 21.1 No No
4 empty 1.94 66.2 21.6 No No
5 empty 1.76 60.1 17.9 No No
6 empty 2.32 56.2 17.5 No No
7 empty 2.29 72.6 13.1 No No
8 empty 2.16 54.6 14.5 No No
9 empty 2.05 76.5 11.7 No No
10 empty 2.18 61.7 13.5 No No
3E1I_C Fibrinogen gamma chain Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.15 73.4 14.4 Yes No
2 empty 1.85 57.9 27.5 No No
3 empty 2.02 64.4 20.9 No No
4 empty 2.47 51.6 16.1 No No
5 empty 2.21 64.8 17.5 No No
6 empty 2.1 72 11.4 No No
7 empty 2.17 67.6 10.6 No No
8 empty 2.12 68.6 11.1 No No
9 empty 2.68 59.9 12 No No
10 empty 2.15 60.2 13.2 No No
1FZF_F Fibrinogen gamma chain Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.09 73.2 19.2 Yes No
2 empty 2.23 60.5 17.5 No No
3 empty 2.32 51.5 19.2 No No
4 empty 1.87 61.3 17.5 No No
5 empty 2.18 67.9 19.3 No No
6 empty 2.11 74 12.3 No No
7 empty 2.08 59.8 12.7 No No
8 empty 2.5 59.7 15.8 No No
9 empty 1.95 74.2 7.2 No No
10 empty 2.27 66.6 13.3 No No
3BVH_C Fibrinogen gamma chain Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.05 76.1 16.3 Yes No
2 empty 2.27 65 21 No No
3 empty 1.87 60.8 22.2 No No
4 empty 2.24 70.1 25.5 No No
5 empty 2.43 56 16.2 No No
6 empty 2.14 71.4 16.6 No No
7 empty 2.45 66.4 16.1 No No
8 empty 2.12 74.8 10 No No
9 empty 2.07 62.3 11.7 No No
10 empty 2.4 57.6 18.4 No No
1FZE_F Fibrinogen gamma chain Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.85 58.9 28.6 Yes No
2 empty 1.97 71 17.9 No No
3 empty 2.34 62.8 25.6 No No
4 empty 2.02 65.5 16.8 No No
5 empty 2.14 68.5 14.5 No No
6 empty 2.38 68.3 19.8 No No
7 empty 2.34 49.2 17.6 No No
8 empty 1.86 72.5 9.1 No No
9 empty 1.81 68.8 10.9 No No
10 empty 2.48 59.1 15.1 No No
2HOD_F Fibrinogen gamma chain Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.95 75 17.3 Yes No
2 empty 1.97 59.9 21.9 No No
3 empty 2.29 65.9 16.9 No No
4 empty 2.25 66.4 26.5 No No
5 empty 2.3 66.4 12.9 No No
6 empty 2.34 70.1 21.3 No No
7 empty 2.27 56.1 17.7 No No
8 empty 2.45 71 11.2 No No
9 empty 2.07 76.5 9.1 No No
10 empty 2.39 50.5 19.6 No No
1RF0_C Fibrinogen gamma chain No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2 65.9 23.8 No No
2 empty 2.48 66.9 34.2 No No
3 empty 2.31 63.6 21.9 No No
4 empty 2.21 63 23.5 No No
5 empty 1.84 58.9 17.6 No No
6 empty 2.42 50.3 16.6 No No
7 empty 2.29 59.2 20.8 No No
8 empty 2.15 54.7 17.4 No No
9 empty 2.22 73.9 7.2 No No
10 empty 2.17 66 15.3 No No
2XNY_C Fibrinogen gamma chain No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.08 70.2 17 No No
2 empty 1.84 60.2 27 No No
3 empty 2.01 66.8 21.8 No No
4 empty 2.18 70.2 16.7 No No
5 empty 2.12 66.7 18.3 No No
6 empty 2.42 51.9 16.1 No No
7 empty 2.16 64.5 14.7 No No
8 empty 2.16 71.6 8.6 No No
9 empty 2.49 62.1 8.7 No No
10 empty 2.48 65.5 12.4 No No
2XNX_F Fibrinogen gamma chain No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.08 68.2 22.4 No No
2 empty 1.79 60.3 27.9 No No
3 empty 2.23 69.4 20.9 No No
4 empty 2.24 63 23 No No
5 empty 2.51 52.1 17.9 No No
6 empty 2.17 70.2 15.4 No No
7 empty 2.79 58.8 16.7 No No
8 empty 2.19 66.6 12.3 No No
9 empty 2.08 64.9 13 No No
10 empty 2.29 55.6 10.5 No No
2Z4E_C Fibrinogen gamma chain Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.09 74.1 16.1 Yes No
2 empty 1.98 59.9 25.8 No No
3 empty 2.16 62 21.4 No No
4 empty 2.24 68.6 14.5 No No
5 empty 2.42 52.5 17.6 No No
6 empty 2.12 67.6 19.8 No No
7 empty 2.46 64.5 16.3 No No
8 empty 2.11 60 11.7 No No
9 empty 2.17 60.3 16.7 No No
10 empty 2.07 71.4 8.4 No No
3H32_F Fibrinogen gamma chain No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.11 67.5 21.1 No No
2 empty 1.96 64.8 16.5 No No
3 empty 1.85 62.1 18.3 No No
4 empty 2.22 60 12.5 No No
5 empty 2.28 50.3 17 No No
6 empty 1.94 56.4 16.9 No No
7 empty 2.23 76.1 11.8 No No
8 empty 1.76 71.4 14.2 No No
9 empty 2.41 55.7 16 No No
10 empty 1.78 75.2 9.9 No No
2XNX_L Fibrinogen gamma chain Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.07 71.6 16.5 Yes No
2 empty 2.18 63.1 21.1 No No
3 empty 2.42 54.2 17.4 No No
4 empty 1.76 60 18.7 No No
5 empty 2.18 63.2 16.3 No No
6 empty 2.28 65.8 17.6 No No
7 empty 2.17 58.2 13.1 No No
8 empty 2.14 70.7 11.1 No No
9 empty 2.12 66.2 14.4 No No
10 empty 2.66 61.1 11.1 No No
2HLO_F Fibrinogen gamma chain Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.24 74 18.4 Yes No
2 empty 1.8 60 26.8 No No
3 empty 2.06 65.4 17.2 No No
4 empty 2.47 50.5 17.9 No No
5 empty 2.08 74 12.1 No No
6 empty 1.97 79.1 9.5 No No
7 empty 2.46 65.3 16.2 No No
8 empty 2.38 74 16.3 No No
9 empty 2.69 70.9 9.6 No No
10 empty 2.17 58.5 12.7 No No
1N86_F Fibrinogen gamma chain Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.09 72.9 16.4 Yes No
2 empty 1.86 58.5 26.8 No No
3 empty 2.46 70.6 30.8 No No
4 empty 2.27 66.3 22.1 No No
5 empty 2.45 70.8 16.2 No No
6 empty 2.03 75.9 9.3 No No
7 empty 2.3 51.9 16.7 No No
8 empty 1.85 69.9 8 No No
9 empty 2.05 53 9.1 No No
10 empty 2.03 62.4 7.5 No No
3GHG_F Fibrinogen gamma chain Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.1 74.9 16.9 Yes No
2 empty 2.29 66.6 28.8 No No
3 empty 2.15 56.7 22.1 No No
4 empty 2.27 66.4 19.9 No No
5 empty 2.23 70.9 11.3 No No
6 empty 1.81 71.8 11.8 No No
7 empty 2.07 56.6 13.2 No No
8 empty 2.19 50.5 13.9 No No
9 empty 1.62 68.3 11.1 No No
10 empty 1.5 70 8.1 No No
1FIC_B Fibrinogen gamma chain Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.98 50.1 25 Yes No
2 empty 2.18 67.7 22 No No
3 empty 2.33 62.6 15.1 No No
4 empty 2.34 65.5 22.4 No No
5 empty 2.27 68.1 19.9 No No
6 empty 2.34 68.7 14.6 No No
7 empty 1.95 63.4 15.1 No No
8 empty 2.17 78.6 10 No No
9 empty 2.37 60.9 12.3 No No
10 empty 1.91 73.1 8.9 No No
1FZE_C Fibrinogen gamma chain Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.02 74.9 16 Yes No
2 empty 2.07 62.7 20.5 No No
3 empty 2.33 65.2 27.4 No No
4 empty 1.74 59.7 23.5 No No
5 empty 2.45 72.5 17.7 No No
6 empty 2.47 59.9 20.4 No No
7 empty 2.36 69.1 14.7 No No
8 empty 2.35 48.4 17.3 No No
9 empty 1.99 71.8 13.6 No No
10 empty 1.8 69.1 14.1 No No
2FFD_F Fibrinogen gamma chain Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.35 67.6 34 Yes No
2 empty 2.12 71.4 16.6 No No
3 empty 2.15 59.4 21.7 No No
4 empty 2.38 65 17.6 No No
5 empty 2.15 72.3 19 No No
6 empty 2.37 50.7 15.6 No No
7 empty 2.19 63.3 14.2 No No
8 empty 2.08 80.2 9.2 No No
9 empty 1.56 75.6 8.2 No No
10 empty 1.69 63.3 13.7 No No
1DUG_B Fibrinogen gamma chain Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.34 65.7 24.8 Yes No
2 empty 2.12 72.6 15.8 No No
3 empty 2.43 64.2 20.3 No No
4 empty 2.1 70.3 11.4 No No
5 empty 2.04 72.8 15 No No
6 empty 2.29 64.3 18.2 No No
7 empty 2.16 68.2 12.7 No No
8 empty 2.18 62.2 12 No No
9 empty 2.04 61.3 9.1 No No
10 empty 2.11 59.2 12.3 No No
2FIB_A Fibrinogen gamma chain Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.2 72.7 15.6 Yes No
2 empty 2.08 61.3 15.2 No No
3 empty 2.21 63.3 25.5 No No
4 empty 2.21 70.8 13.5 No No
5 empty 2.21 62.4 14.8 No No
6 empty 2.52 59.9 10.9 No No
7 empty 1.75 77.6 7.5 No No
8 empty 1.82 62.8 11.1 No No
9 empty 2.38 65.2 9.3 No No
10 empty 1.65 54 10.2 No No
1FZG_C Fibrinogen gamma chain No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.88 71.1 16.3 No No
2 empty 2.32 60.8 17.6 No No
3 empty 1.9 62.2 17.4 No No
4 empty 2.12 65.1 16.7 No No
5 empty 2.38 52.3 17.3 No No
6 empty 2.04 70 19.7 No No
7 empty 2.06 75.2 10.2 No No
8 empty 2.12 63 14.3 No No
9 empty 2.31 58.6 13.1 No No
10 empty 1.97 61.4 10.1 No No
3GHG_C Fibrinogen gamma chain No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.25 62.5 22.1 No No
2 empty 2.15 71.4 17.4 No No
3 empty 2.15 46.7 17.3 No No
4 empty 1.67 62.6 18.4 No No
5 empty 1.91 71.1 10.6 No No
6 empty 2.23 60.4 17.7 No No
7 empty 2.26 63.9 18.9 No No
8 empty 2.07 54.9 12.8 No No
9 empty 1.94 51.9 12.7 No No
10 empty 1.94 62.4 12.3 No No
2OYI_F Fibrinogen gamma chain No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.04 70.6 21.6 No No
2 empty 2.04 60.2 26.5 No No
3 empty 2.33 65.1 16.8 No No
4 empty 2.12 70.5 19.4 No No
5 empty 1.97 74.5 15.4 No No
6 empty 2.52 66.3 17.7 No No
7 empty 2.36 51.3 17.2 No No
8 empty 2.27 79.6 8.7 No No
9 empty 2.1 64 20.8 No No
10 empty 2.19 63.9 11.3 No No
2HOD_C Fibrinogen gamma chain No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.03 67.7 23.1 No No
2 empty 1.68 55.4 27.4 No No
3 empty 2.27 61.7 23.9 No No
4 empty 2.1 67.9 17.9 No No
5 empty 2.19 70.5 10.4 No No
6 empty 2.28 57.9 16.9 No No
7 empty 1.71 75.1 17.6 No No
8 empty 2.55 62.9 16.6 No No
9 empty 2.18 62.9 14.2 No No
10 empty 2.22 76.5 8.9 No No
1FZF_C Fibrinogen gamma chain No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.07 69.2 19.7 No No
2 empty 2 60.2 21 No No
3 empty 2.29 61.6 16.9 No No
4 empty 2.31 51.8 19 No No
5 empty 2.07 68.6 17.7 No No
6 empty 2.14 72.3 10 No No
7 empty 2.4 59.8 17.5 No No
8 empty 2.11 73.6 7.5 No No
9 empty 2.16 67.9 12.3 No No
10 empty 2.12 61.8 11.6 No No
3E1I_F Fibrinogen gamma chain Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.3 74 19.8 Yes No
2 empty 1.84 59.3 26.7 No No
3 empty 2.32 50.9 17.2 No No
4 empty 2.37 64.8 16.5 No No
5 empty 2.28 66.1 16.6 No No
6 empty 2.3 62.6 15.2 No No
7 empty 2.35 72.9 15.5 No No
8 empty 2.58 55.2 16.4 No No
9 empty 2.19 69.5 12.8 No No
10 empty 2.6 65.6 10.3 No No
2OYI_C Fibrinogen gamma chain Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.11 74.5 18.8 Yes No
2 empty 1.81 61 25.5 No No
3 empty 2.32 62.6 22.2 No No
4 empty 2.1 73.1 17.3 No No
5 empty 2.18 71.7 20.4 No No
6 empty 2.42 55.7 17.7 No No
7 empty 2.57 61.2 19.9 No No
8 empty 2 61.4 12.8 No No
9 empty 2.18 72.1 9 No No
10 empty 2.31 53.3 15.4 No No
1LT9_C Fibrinogen gamma chain No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.07 68.9 21.6 No No
2 empty 2.34 62.3 21.3 No No
3 empty 2.24 54.7 22 No No
4 empty 2.39 67.3 26.2 No No
5 empty 2.36 52.8 16.8 No No
6 empty 2.5 59.5 20 No No
7 empty 2.21 70.7 13.2 No No
8 empty 2.01 60.7 17.1 No No
9 empty 2.1 50 15.4 No No
10 empty 2.04 60.8 13.4 No No
3GHG_L Fibrinogen gamma chain Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.01 75.9 16.7 Yes No
2 empty 2.15 52 20.9 No No
3 empty 2.07 65.6 22.9 No No
4 empty 2.2 62.5 19.1 No No
5 empty 2.11 66.9 12.6 No No
6 empty 1.8 70.7 13.6 No No
7 empty 2.26 58.9 14.2 No No
8 empty 1.72 60.2 11.4 No No
9 empty 2.01 60 20.3 No No
10 empty 2.37 51.6 14.5 No No
2A45_L Fibrinogen gamma chain No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.66 52.3 17.2 No No
2 empty 2.04 72.6 7.9 No No
3 empty 2.37 52.3 10.1 No No
4 empty 2.73 65.8 7.2 No No
5 empty .63 59.1 6.2 No No
6 empty 1.77 55 6.4 No No
7 empty 2.91 48.2 7.6 No No
8 empty 2 56.9 6.6 No No
9 empty 2.1 59 5.9 No No
10 empty 2.2 56.8 6.9 No No
1RF0_F Fibrinogen gamma chain Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.02 70.9 26.3 Yes No
2 empty 1.88 59.6 27.8 No No
3 empty 2.44 71.5 20 No No
4 empty 2.34 63.8 17.6 No No
5 empty 2.25 64.4 22.9 No No
6 empty 2.19 64.2 13.4 No No
7 empty 2.13 72.9 9.5 No No
8 empty 2.62 52.5 11.6 No No
9 empty 2.04 67.1 16.1 No No
10 empty 2.45 49.5 13 No No
2FFD_C Fibrinogen gamma chain Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.17 76.9 15.4 Yes No
2 empty 2.13 58.4 24.4 No No
3 empty 2.31 62.5 22.4 No No
4 empty 2.3 70.4 20.7 No No
5 empty 2.21 69 16.1 No No
6 empty 2.51 57.1 16.1 No No
7 empty 2.51 65.1 15.4 No No
8 empty 2.26 71.8 8.7 No No
9 empty 2.03 54 19.7 No No
10 empty 2.08 58.6 10 No No
3HUS_F Fibrinogen gamma chain No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.18 70.2 17.9 No No
2 empty 1.84 56.1 26.5 No No
3 empty 2.24 64.2 20.4 No No
4 empty 2.63 58.3 20.2 No No
5 empty 2.15 73.9 9.1 No No
6 empty 2.31 69.5 17.8 No No
7 empty 2.05 54.6 15.9 No No
8 empty 1.89 67.2 11.2 No No
9 empty 2.48 55 13.6 No No
10 empty 2.68 67 13.8 No No
1RE4_C Fibrinogen gamma chain No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.15 68.9 20.2 No No
2 empty 2.39 68.1 33.6 No No
3 empty 1.86 61.8 26.3 No No
4 empty 2.13 61.1 21.2 No No
5 empty 2.23 63.4 20.7 No No
6 empty 2.27 49.3 17.3 No No
7 empty 2.3 52.9 19.1 No No
8 empty 2.07 60.1 20.3 No No
9 empty 2.04 71.8 7.2 No No
10 empty 2.16 68.7 8.4 No No
1RF1_C Fibrinogen gamma chain Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.29 69.1 25.1 Yes Yes
2 empty 1.84 58.9 26 No No
3 empty 2.16 62.4 18.3 No No
4 empty 2.1 67.4 21.4 No No
5 empty 2.23 69.9 14.6 No No
6 empty 2.59 53.2 17.7 No No
7 empty 1.84 53.3 19 No No
8 empty 2.57 59 12.7 No No
9 empty 2.12 59.3 13.3 No No
10 empty 2.36 71.1 7.2 No No
2H43_F Fibrinogen gamma chain Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.07 72.5 18.3 Yes No
2 empty 2.29 62.8 22.6 No No
3 empty 2.29 64.8 21.9 No No
4 empty 1.65 59.5 21.4 No No
5 empty 2.23 56 21.8 No No
6 empty 1.96 77.7 11.5 No No
7 empty 2.19 68.5 22.3 No No
8 empty 2.38 48.3 18.5 No No
9 empty 2.27 73.6 12.2 No No
10 empty 2.43 61.5 11.9 No No
1FZA_F Fibrinogen gamma chain Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.32 64.8 31.4 Yes No
2 empty 1.76 61.6 26 No No
3 empty 1.91 71.2 16.8 No No
4 empty 2.23 66.4 24.8 No No
5 empty 2.2 64.8 22.6 No No
6 empty 2.31 49 16.9 No No
7 empty 1.88 63.3 20.5 No No
8 empty 1.75 68.9 8.4 No No
9 empty 2.49 62.2 11.7 No No
10 empty 1.83 95.7 0 Yes No
2HOD_I Fibrinogen gamma chain Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.97 70.4 25.9 Yes No
2 empty 1.86 50.5 29.1 No No
3 empty 2.14 66 22 No No
4 empty 2.09 66.7 15.6 No No
5 empty 2.14 69.5 12.4 No No
6 empty 2.31 60.4 20.8 No No
7 empty 2.2 64.4 14.8 No No
8 empty 1.85 64.3 11.4 No No
9 empty 2.63 61.4 12.7 No No
10 empty 2.19 78.1 7.6 No No
1LTJ_F Fibrinogen gamma chain Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.14 74 17.9 Yes No
2 empty 1.93 60.3 27.1 No No
3 empty 2.25 61.8 22.6 No No
4 empty 2.45 63.2 21.1 No No
5 empty 2.16 68.8 21.4 No No
6 empty 2.07 75.3 15.6 No No
7 empty 2.33 53.2 15.7 No No
8 empty 2.06 62.2 20.7 No No
9 empty 2.1 74.6 9.4 No No
10 empty 2.51 57.8 12.1 No No
1DUG_A Fibrinogen gamma chain Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.38 68.3 30.6 Yes No
2 bound 2.22 66 28.8 No No
3 empty 2.37 62.1 24.5 No No
4 empty 2.14 66.9 13.1 No No
5 empty 2.69 69.3 11.3 No No
6 empty 1.91 65.3 14.7 No No
7 empty 1.94 60.9 17.3 No No
8 empty 2.28 77.9 10.5 No No
9 empty 1.56 67.5 11.5 No No
10 empty 2.39 64.8 16.2 No No
2XNX_C Fibrinogen gamma chain No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.97 69.8 19.6 No No
2 empty 2.3 68.1 20.2 No No
3 empty 2.18 61.2 24.4 No No
4 empty 1.56 59.5 20.6 No No
5 empty 2.3 67.7 16.7 No No
6 empty 2.21 75.8 13.6 No No
7 empty 2.41 55.3 16.8 No No
8 empty 2.27 54.7 14.2 No No
9 empty 2.63 49.7 11.8 No No
10 empty 1.83 62 12.3 No No
2HPC_F Fibrinogen gamma chain Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.95 77.4 17.4 Yes No
2 empty 2.26 63.3 16.4 No No
3 empty 1.85 59.2 19 No No
4 empty 2.28 51.3 21.5 No No
5 empty 2.46 51.9 16.7 No No
6 empty 2.24 71 12.4 No No
7 empty 2.31 72.7 8.7 No No
8 empty 2.09 65.9 13.6 No No
9 empty 2.03 73.3 9 No No
10 empty 2.07 63.3 12.9 No No
2OYH_C Fibrinogen gamma chain Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2 71.2 21.6 Yes Yes
2 empty 1.83 59.1 26.6 No No
3 empty 2.24 64.7 19.8 No No
4 empty 2.07 67.3 21.4 No No
5 empty 2.06 71 16.1 No No
6 empty 2.36 62.5 19.5 No No
7 empty 2.03 59.6 16.5 No No
8 empty 2.5 55.2 18.4 No No
9 empty 2.24 54.1 12.1 No No
10 empty 2.44 71.3 7.7 No No
1FZG_F Fibrinogen gamma chain Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.3 72.1 18.8 Yes No
2 empty 2.11 62.5 17.4 No No
3 empty 1.87 62.1 22.8 No No
4 empty 2.36 51.4 17.5 No No
5 empty 2.23 66.5 16.2 No No
6 empty 2.47 61.6 17 No No
7 empty 1.95 61.2 14.1 No No
8 empty 2.09 71.1 13.6 No No
9 empty 2.1 76.9 7.6 No No
10 empty 2.37 59 17.3 No No
1FIB_A Fibrinogen gamma chain No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.1 66.5 19.4 No No
2 empty 2.33 66 24.8 No No
3 empty 2.07 60.6 16.4 No No
4 empty 2.17 72.4 15 No No
5 empty 2.18 63.4 18.7 No No
6 empty 2.49 58.2 10.6 No No
7 empty 1.94 57.6 12 No No
8 empty 2.6 61.7 11.6 No No
9 empty 1.74 75.2 7.8 No No
10 empty 2.7 68.4 11 No No
3FIB_A Fibrinogen gamma chain No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.12 67.7 18.2 No No
2 empty 2.15 60.8 23 No No
3 empty 2.34 65.1 24.8 No No
4 empty 2.18 72.8 15.8 No No
5 empty 2.29 61 16.5 No No
6 empty 2.48 64.6 11.4 No No
7 empty 2.63 58.7 10.5 No No
8 empty 1.85 72.4 7.9 No No
9 empty 2.08 58.9 8.9 No No
10 empty 1.54 67.3 12 No No
1RE4_F Fibrinogen gamma chain Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.23 66.2 27.1 Yes No
2 empty 1.86 63.9 26.7 No No
3 empty 2.26 62.6 17.8 No No
4 empty 2.28 66.1 23.4 No No
5 empty 2.57 61.8 21 No No
6 empty 2.24 50.4 17.1 No No
7 empty 2.06 74.1 14.5 No No
8 empty 2.04 62.1 21.3 No No
9 empty 2.16 71 12.8 No No
10 empty 2.54 57.1 9.1 No No
2Q9I_C Fibrinogen gamma chain Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.21 69.5 21 Yes Yes
2 empty 2.29 65.9 31 No No
3 empty 2.22 60.1 18.6 No No
4 empty 1.77 63 17 No No
5 empty 2.09 70.6 11.6 No No
6 empty 2.21 58.4 19.9 No No
7 empty 2.07 60.1 13.6 No No
8 empty 2.62 53.2 17.8 No No
9 empty 1.89 71.3 8.3 No No
10 empty 2.35 59.3 10.8 No No
2Q9I_F Fibrinogen gamma chain Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.22 70.8 23 Yes Yes
2 empty 2.26 62.7 18.2 No No
3 empty 2.38 67.4 26.8 No No
4 empty 2.3 49.9 19.3 No No
5 empty 1.75 62.9 16.9 No No
6 empty 2.04 71.7 11.4 No No
7 empty 2.31 59.9 18.9 No No
8 empty 2.05 60.8 12.4 No No
9 empty 1.87 75.7 8.2 No No
10 empty 2.47 57.6 8.7 No No
1FZA_C Fibrinogen gamma chain No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.2 65.5 21.4 No No
2 empty 2 72.8 14 No No
3 empty 2.4 63.4 19.8 No No
4 empty 2.03 66.7 22.3 No No
5 empty 1.76 64.6 16.9 No No
6 empty 2.36 48.5 16.4 No No
7 empty 1.84 62.8 20.5 No No
8 empty 2.23 56.2 14.7 No No
9 empty 1.8 66.7 14.8 No No
10 empty 1.79 67.8 12.4 No No
2XNX_I Fibrinogen gamma chain Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.92 58.6 27.6 Yes No
2 empty 2.28 66.7 28.7 No No
3 empty 1.99 63.5 23.9 No No
4 empty 2.55 51.7 17 No No
5 empty 2.14 66.3 17.9 No No
6 empty 2.09 67.8 12.4 No No
7 empty 2.23 69.2 15.7 No No
8 empty 1.64 68.3 8.8 No No
9 empty 2.24 68.1 8.6 No No
10 empty 2.37 68.1 10.9 No No
3HUS_C Fibrinogen gamma chain Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.28 74.1 18.3 Yes Yes
2 empty 1.72 60.4 26.4 No No
3 empty 2.41 63.4 22.1 No No
4 empty 2.78 57.3 21.7 No No
5 empty 2.09 65.8 17.3 No No
6 empty 2.25 69.4 17.4 No No
7 empty 2.45 55.6 14.9 No No
8 empty 1.98 65.9 12.1 No No
9 empty 2.29 80.4 9.4 No No
10 empty 1.85 63 17.8 No No
1FID_A Fibrinogen gamma chain Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.28 57.7 25.1 Yes No
2 empty 2.06 66.7 20.9 No No
3 empty 2.02 58.9 17.4 No No
4 empty 2.23 74.3 14.3 No No
5 empty 1.96 66.1 15 No No
6 empty 2.69 47.7 14.1 No No
7 empty 2.76 59.2 15 No No
8 empty 2.18 69.9 7.3 No No
9 empty 2.03 73.7 9.3 No No
10 empty 2.02 63.2 9.1 No No
3GHG_I Fibrinogen gamma chain Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.14 73 17.9 Yes No
2 empty 2.25 62.1 28 No No
3 empty 1.77 54.3 17.4 No No
4 empty 1.83 61.6 22.7 No No
5 empty 2.36 51.4 15 No No
6 empty 2.37 59.7 18.2 No No
7 empty 2.37 51.1 17.3 No No
8 empty 1.78 77.1 8.6 No No
9 empty 2.01 69.7 18.3 No No
10 empty 2.31 71 12.6 No No
1FZB_F Fibrinogen gamma chain Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.13 61.7 25 Yes No
2 empty 2.09 73.1 17 No No
3 empty 2.14 59.5 21.5 No No
4 empty 2.2 48.3 17.3 No No
5 empty 2.03 69.3 17.8 No No
6 empty 2.2 65.9 17 No No
7 empty 2.48 71 16.2 No No
8 empty 1.69 56.1 13.3 No No
9 empty 2.11 67 14 No No
10 empty 1.25 76.5 8.6 No No
2XNY_F Fibrinogen gamma chain Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.12 74.3 14.5 Yes No
2 empty 1.84 58.5 26.2 No No
3 empty 2.07 62.3 16.7 No No
4 empty 2.18 69.7 20.7 No No
5 empty 2.41 54.9 17.3 No No
6 empty 2.25 70.3 15.5 No No
7 empty 2.17 65.5 15.7 No No
8 empty 2.02 72.2 9.9 No No
9 empty 2.44 65.2 10.2 No No
10 empty 1.71 71.1 7.9 No No
1N86_C Fibrinogen gamma chain Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.14 76.4 17.6 Yes No
2 empty 2.29 63 21 No No
3 empty 2.25 56.7 20.9 No No
4 empty 1.72 63.2 18.1 No No
5 empty 2.26 66.2 17.2 No No
6 empty 2.33 71 15.1 No No
7 empty 2.42 72.3 16.6 No No
8 empty 1.94 75.2 14.1 No No
9 empty 2.44 53.8 17.1 No No
10 empty 2.15 60.9 16.2 No No
1FZB_C Fibrinogen gamma chain Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.04 75.2 17.8 Yes No
2 empty 1.91 62.7 25.5 No No
3 empty 2.14 68.8 18.8 No No
4 empty 2.32 53.2 18 No No
5 empty 1.8 72.3 11.6 No No
6 empty 2.23 66.4 14.6 No No
7 empty 2.42 69.9 23.5 No No
8 empty 2.18 49.8 14.4 No No
9 empty 1.78 69.5 9.7 No No
10 empty 1.24 76.2 10.5 No No
2A45_I Fibrinogen gamma chain No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.51 49.8 10.6 No No
2 empty 1.24 61.1 11.4 No No
3 empty 2.66 61.3 8.8 No No
4 empty 2.81 62.2 6.8 No No
5 empty 2.01 56 6.7 No No
6 empty 2.12 53.4 4.9 No No
7 empty 2.03 56.5 6.2 No No
2HPC_C Fibrinogen gamma chain No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.24 69.4 18.3 No No
2 empty 2.21 50.9 16.7 No No
3 empty 2.1 67.8 18.6 No No
4 empty 2.37 63.7 13.2 No No
5 empty 1.99 66.6 11.1 No No
6 empty 1.59 57.2 13.8 No No
7 empty 1.99 65.6 16.4 No No
8 empty 2.04 74.6 9.4 No No
9 empty 2.26 81.5 7.7 No No
10 empty 1.92 68.9 8.6 No No
1LT9_F Fibrinogen gamma chain Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.25 66.2 26.3 Yes No
2 empty 2.29 65 23.6 No No
3 empty 2.43 65.2 20.7 No No
4 empty 2.3 63.7 25.5 No No
5 empty 2.36 51.3 17.4 No No
6 empty 1.61 62.7 18.2 No No
7 empty 2.1 74.8 13.6 No No
8 empty 2.12 56.3 17.2 No No
9 empty 2.07 73.9 9.9 No No
10 empty 2.06 62.7 18.2 No No
1RF1_F Fibrinogen gamma chain Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.27 72.9 21.5 Yes Yes
2 empty 2.14 57.5 21.7 No No
3 empty 2.26 66.1 17.5 No No
4 empty 2.56 58.4 21.4 No No
5 empty 1.97 68.7 21.6 No No
6 empty 2.29 50 17.5 No No
7 empty 2.14 72 11.9 No No
8 empty 2 65.4 18.1 No No
9 empty 2.2 70.9 8.3 No No
10 empty 1.55 73.5 8.6 No No
1FZC_C Fibrinogen gamma chain Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.16 75.6 17.2 Yes No
2 empty 1.9 58.4 26 No No
3 empty 2.26 61.7 21.3 No No
4 empty 2.04 69.4 19.6 No No
5 empty 2.22 63.5 17.6 No No
6 empty 2.06 72.5 13.8 No No
7 empty 2.41 50.7 16.7 No No
8 empty 2.14 59.8 10.8 No No
9 empty 2.05 66.9 10.8 No No
10 empty 2.45 67.3 12.4 No No
2H43_C Fibrinogen gamma chain No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.08 70.3 18.4 No No
2 empty 2.3 67.8 22 No No
3 empty 2.34 65.2 22 No No
4 empty 2.19 56 20.5 No No
5 empty 2.17 69.8 17.3 No No
6 empty 2.03 69.5 15 No No
7 empty 2.6 51.9 17.6 No No
8 empty 1.59 60.5 11.7 No No
9 empty 2.22 75.9 9.1 No No
10 empty 1.63 78.1 7.6 No No
1FZC_F Fibrinogen gamma chain Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.9 56.5 32.4 Yes No
2 empty 2.21 76.9 16.6 No No
3 empty 2.27 63.1 19.3 No No
4 empty 2.06 74.1 17.3 No No
5 empty 2.21 69.7 20.4 No No
6 empty 1.97 74.6 12.7 No No
7 empty 2.12 63.6 13.6 No No
8 empty 2.4 63.8 10.6 No No
9 empty 2.35 62.3 9.6 No No
10 empty 2.26 58.1 9.9 No No
3BVH_F Fibrinogen gamma chain Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.26 72.8 19.9 Yes No
2 empty 1.86 60.3 25.2 No No
3 empty 2.24 63 16.5 No No
4 empty 2.21 72.1 13.8 No No
5 empty 2.14 70.6 19.7 No No
6 empty 2.02 62.5 20.9 No No
7 empty 2.21 69.3 9.2 No No
8 empty 2.26 53.3 13.6 No No
9 empty 2.29 54.4 11.9 No No
10 empty 2.16 62.3 13.7 No No
1LTJ_C Fibrinogen gamma chain Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.18 75 14.8 Yes No
2 empty 1.8 61 25.4 No No
3 empty 2.32 62.6 20.9 No No
4 empty 2.16 69 19.5 No No
5 empty 2.14 71.2 14.4 No No
6 empty 2.48 61.1 18.7 No No
7 empty 1.9 61 12.5 No No
8 empty 2.61 54.8 14.9 No No
9 empty 2.03 70.5 9.2 No No
10 empty 2.22 56.1 13 No No
2HPC_L Fibrinogen gamma chain Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.02 74.1 18.2 Yes No
2 empty 2.25 64.9 15.6 No No
3 empty 1.84 59.5 18.6 No No
4 empty 2.12 70.5 16.7 No No
5 empty 2.16 66 18.4 No No
6 empty 2.25 54.2 15.6 No No
7 empty 2.22 70.6 11.5 No No
8 empty 2.24 71.6 9.6 No No
9 empty 2.04 64.2 12.3 No No
10 empty 2.4 52.5 12.6 No No
2HLO_C Fibrinogen gamma chain No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.05 69.1 16.5 No No
2 empty 2.22 60.6 20.6 No No
3 empty 1.86 61.8 18.6 No No
4 empty 2.08 69.7 17.5 No No
5 empty 2.42 50 16.4 No No
6 empty 2.2 67.9 22.1 No No
7 empty 2.26 65.6 20.5 No No
8 empty 2.07 76 9.8 No No
9 empty 2.41 56.3 17.1 No No
10 empty 2.53 72.9 10 No No

Domain-based assessment (last updated 30/07/2012)


Domains assessed82
Domains assessed as druggable using the strict criteria7
Domains assessed as druggable using the relaxed criteria32

PDB (Domain) Protein Name Domain Resolution Ligands Druggable Relaxed Druggable Strict
1DUG_A (4175200) Fibrinogen gamma chain GST C-terminal domain-like, GST C-terminal domain-like, Glutathione S-transferase (GST) C-terminal domain (Homo Multimer) 1.7Å Yes Yes
1DUG_B (4175200) Fibrinogen gamma chain GST C-terminal domain-like, GST C-terminal domain-like, Glutathione S-transferase (GST) C-terminal domain (Homo Multimer) 1.7Å Yes Yes
1FIB_A (42456) Fibrinogen gamma chain Fibrinogen C-terminal domain-like, Fibrinogen C-terminal domain-like, Fibrinogen C-terminal domain-like 2.03Å No No
1FIC_A (4164823) Fibrinogen gamma chain Fibrinogen C-terminal domain-like, Fibrinogen C-terminal domain-like, Fibrinogen C-terminal domain-like (Homo Multimer) 2.5Å Yes Yes
1FIC_B (42459) Fibrinogen gamma chain Fibrinogen C-terminal domain-like, Fibrinogen C-terminal domain-like, Fibrinogen C-terminal domain-like 2.5Å Yes No
1FIC_A (42458) Fibrinogen gamma chain Fibrinogen C-terminal domain-like, Fibrinogen C-terminal domain-like, Fibrinogen C-terminal domain-like 2.5Å Yes No
1FIC_B (4164823) Fibrinogen gamma chain Fibrinogen C-terminal domain-like, Fibrinogen C-terminal domain-like, Fibrinogen C-terminal domain-like (Homo Multimer) 2.5Å Yes Yes
1FID_A (42454) Fibrinogen gamma chain Fibrinogen C-terminal domain-like, Fibrinogen C-terminal domain-like, Fibrinogen C-terminal domain-like 2.1Å Yes No
1FZA_F (42483) Fibrinogen gamma chain Fibrinogen C-terminal domain-like, Fibrinogen C-terminal domain-like, Fibrinogen C-terminal domain-like 2.9Å Yes No
1FZA_C (45622) Fibrinogen gamma chain Parallel coiled-coil, Fibrinogen coiled-coil and central regions, Fibrinogen coiled-coil and central regions 2.9Å No No
1FZA_F (45625) Fibrinogen gamma chain Parallel coiled-coil, Fibrinogen coiled-coil and central regions, Fibrinogen coiled-coil and central regions 2.9Å No No
1FZA_C (42481) Fibrinogen gamma chain Fibrinogen C-terminal domain-like, Fibrinogen C-terminal domain-like, Fibrinogen C-terminal domain-like 2.9Å No No
1FZB_F (45613) Fibrinogen gamma chain Parallel coiled-coil, Fibrinogen coiled-coil and central regions, Fibrinogen coiled-coil and central regions 2.9Å No No
1FZB_C (45610) Fibrinogen gamma chain Parallel coiled-coil, Fibrinogen coiled-coil and central regions, Fibrinogen coiled-coil and central regions 2.9Å No No
1FZB_C (42473) Fibrinogen gamma chain Fibrinogen C-terminal domain-like, Fibrinogen C-terminal domain-like, Fibrinogen C-terminal domain-like 2.9Å Yes No
1FZB_F (42475) Fibrinogen gamma chain Fibrinogen C-terminal domain-like, Fibrinogen C-terminal domain-like, Fibrinogen C-terminal domain-like 2.9Å Yes No
1FZC_F (45595) Fibrinogen gamma chain Parallel coiled-coil, Fibrinogen coiled-coil and central regions, Fibrinogen coiled-coil and central regions 2.3Å No No
1FZC_C (42461) Fibrinogen gamma chain Fibrinogen C-terminal domain-like, Fibrinogen C-terminal domain-like, Fibrinogen C-terminal domain-like 2.3Å Yes No
1FZC_F (42463) Fibrinogen gamma chain Fibrinogen C-terminal domain-like, Fibrinogen C-terminal domain-like, Fibrinogen C-terminal domain-like 2.3Å Yes No
1FZC_C (45592) Fibrinogen gamma chain Parallel coiled-coil, Fibrinogen coiled-coil and central regions, Fibrinogen coiled-coil and central regions 2.3Å No No
1FZE_F (42479) Fibrinogen gamma chain Fibrinogen C-terminal domain-like, Fibrinogen C-terminal domain-like, Fibrinogen C-terminal domain-like 3Å Yes No
1FZE_C (45616) Fibrinogen gamma chain Parallel coiled-coil, Fibrinogen coiled-coil and central regions, Fibrinogen coiled-coil and central regions 3Å No No
1FZE_F (45619) Fibrinogen gamma chain Parallel coiled-coil, Fibrinogen coiled-coil and central regions, Fibrinogen coiled-coil and central regions 3Å No No
1FZE_C (42477) Fibrinogen gamma chain Fibrinogen C-terminal domain-like, Fibrinogen C-terminal domain-like, Fibrinogen C-terminal domain-like 3Å Yes No
1FZF_F (45601) Fibrinogen gamma chain Parallel coiled-coil, Fibrinogen coiled-coil and central regions, Fibrinogen coiled-coil and central regions 2.7Å No No
1FZF_C (42465) Fibrinogen gamma chain Fibrinogen C-terminal domain-like, Fibrinogen C-terminal domain-like, Fibrinogen C-terminal domain-like 2.7Å No No
1FZF_F (42467) Fibrinogen gamma chain Fibrinogen C-terminal domain-like, Fibrinogen C-terminal domain-like, Fibrinogen C-terminal domain-like 2.7Å Yes No
1FZF_C (45598) Fibrinogen gamma chain Parallel coiled-coil, Fibrinogen coiled-coil and central regions, Fibrinogen coiled-coil and central regions 2.7Å No No
1FZG_C (42469) Fibrinogen gamma chain Fibrinogen C-terminal domain-like, Fibrinogen C-terminal domain-like, Fibrinogen C-terminal domain-like 2.5Å No No
1FZG_F (42471) Fibrinogen gamma chain Fibrinogen C-terminal domain-like, Fibrinogen C-terminal domain-like, Fibrinogen C-terminal domain-like 2.5Å Yes No
1FZG_C (45604) Fibrinogen gamma chain Parallel coiled-coil, Fibrinogen coiled-coil and central regions, Fibrinogen coiled-coil and central regions 2.5Å No No
1FZG_F (45607) Fibrinogen gamma chain Parallel coiled-coil, Fibrinogen coiled-coil and central regions, Fibrinogen coiled-coil and central regions 2.5Å No No
1LT9_F (78197) Fibrinogen gamma chain Parallel coiled-coil, Fibrinogen coiled-coil and central regions, Fibrinogen coiled-coil and central regions 2.8Å No No
1LT9_C (78191) Fibrinogen gamma chain Fibrinogen C-terminal domain-like, Fibrinogen C-terminal domain-like, Fibrinogen C-terminal domain-like 2.8Å No No
1LT9_F (78196) Fibrinogen gamma chain Fibrinogen C-terminal domain-like, Fibrinogen C-terminal domain-like, Fibrinogen C-terminal domain-like 2.8Å Yes No
1LT9_C (78192) Fibrinogen gamma chain Parallel coiled-coil, Fibrinogen coiled-coil and central regions, Fibrinogen coiled-coil and central regions 2.8Å No No
1LTJ_C (78201) Fibrinogen gamma chain Fibrinogen C-terminal domain-like, Fibrinogen C-terminal domain-like, Fibrinogen C-terminal domain-like 2.8Å Yes No
1LTJ_C (78202) Fibrinogen gamma chain Parallel coiled-coil, Fibrinogen coiled-coil and central regions, Fibrinogen coiled-coil and central regions 2.8Å No No
1LTJ_F (78206) Fibrinogen gamma chain Fibrinogen C-terminal domain-like, Fibrinogen C-terminal domain-like, Fibrinogen C-terminal domain-like 2.8Å Yes No
1LTJ_F (78207) Fibrinogen gamma chain Parallel coiled-coil, Fibrinogen coiled-coil and central regions, Fibrinogen coiled-coil and central regions 2.8Å No No
1N86_F (80285) Fibrinogen gamma chain Fibrinogen C-terminal domain-like, Fibrinogen C-terminal domain-like, Fibrinogen C-terminal domain-like 3.1Å Yes No
1N86_F (80286) Fibrinogen gamma chain Parallel coiled-coil, Fibrinogen coiled-coil and central regions, Fibrinogen coiled-coil and central regions 3.1Å No No
1N86_C (80281) Fibrinogen gamma chain Parallel coiled-coil, Fibrinogen coiled-coil and central regions, Fibrinogen coiled-coil and central regions 3.1Å No No
1N86_C (80280) Fibrinogen gamma chain Fibrinogen C-terminal domain-like, Fibrinogen C-terminal domain-like, Fibrinogen C-terminal domain-like 3.1Å Yes No
1RE3_C (104895) Fibrinogen gamma chain Parallel coiled-coil, Fibrinogen coiled-coil and central regions, Fibrinogen coiled-coil and central regions 2.45Å No No
1RE3_F (104900) Fibrinogen gamma chain Parallel coiled-coil, Fibrinogen coiled-coil and central regions, Fibrinogen coiled-coil and central regions 2.45Å No No
1RE3_C (104894) Fibrinogen gamma chain Fibrinogen C-terminal domain-like, Fibrinogen C-terminal domain-like, Fibrinogen C-terminal domain-like 2.45Å No No
1RE3_F (104899) Fibrinogen gamma chain Fibrinogen C-terminal domain-like, Fibrinogen C-terminal domain-like, Fibrinogen C-terminal domain-like 2.45Å Yes No
1RE4_C (104905) Fibrinogen gamma chain Parallel coiled-coil, Fibrinogen coiled-coil and central regions, Fibrinogen coiled-coil and central regions 2.7Å No No
1RE4_F (104910) Fibrinogen gamma chain Parallel coiled-coil, Fibrinogen coiled-coil and central regions, Fibrinogen coiled-coil and central regions 2.7Å No No
1RE4_F (104909) Fibrinogen gamma chain Fibrinogen C-terminal domain-like, Fibrinogen C-terminal domain-like, Fibrinogen C-terminal domain-like 2.7Å Yes No
1RE4_C (104904) Fibrinogen gamma chain Fibrinogen C-terminal domain-like, Fibrinogen C-terminal domain-like, Fibrinogen C-terminal domain-like 2.7Å No No
1RF0_F (97346) Fibrinogen gamma chain Fibrinogen C-terminal domain-like, Fibrinogen C-terminal domain-like, Fibrinogen C-terminal domain-like 2.8Å Yes No
1RF0_F (97347) Fibrinogen gamma chain Parallel coiled-coil, Fibrinogen coiled-coil and central regions, Fibrinogen coiled-coil and central regions 2.8Å No No
1RF0_C (97342) Fibrinogen gamma chain Parallel coiled-coil, Fibrinogen coiled-coil and central regions, Fibrinogen coiled-coil and central regions 2.8Å No No
1RF0_C (97341) Fibrinogen gamma chain Fibrinogen C-terminal domain-like, Fibrinogen C-terminal domain-like, Fibrinogen C-terminal domain-like 2.8Å No No
1RF1_C (97351) Fibrinogen gamma chain Fibrinogen C-terminal domain-like, Fibrinogen C-terminal domain-like, Fibrinogen C-terminal domain-like 2.53Å Yes Yes
1RF1_C (97352) Fibrinogen gamma chain Parallel coiled-coil, Fibrinogen coiled-coil and central regions, Fibrinogen coiled-coil and central regions 2.53Å No No
1RF1_F (97357) Fibrinogen gamma chain Parallel coiled-coil, Fibrinogen coiled-coil and central regions, Fibrinogen coiled-coil and central regions 2.53Å No No
1RF1_F (97356) Fibrinogen gamma chain Fibrinogen C-terminal domain-like, Fibrinogen C-terminal domain-like, Fibrinogen C-terminal domain-like 2.53Å Yes Yes
2A45_I (3040132) Fibrinogen gamma chain PFAM, PFAM, PFAM Fib_gamma 3.65Å No No
2FIB_A (42457) Fibrinogen gamma chain Fibrinogen C-terminal domain-like, Fibrinogen C-terminal domain-like, Fibrinogen C-terminal domain-like 2Å Yes No
2OYH_C (145738) Fibrinogen gamma chain Fibrinogen C-terminal domain-like, Fibrinogen C-terminal domain-like, Fibrinogen C-terminal domain-like 2.4Å No Yes
2OYH_C (145739) Fibrinogen gamma chain Parallel coiled-coil, Fibrinogen coiled-coil and central regions, Fibrinogen coiled-coil and central regions 2.4Å No No
2OYI_C (145740) Fibrinogen gamma chain Fibrinogen C-terminal domain-like, Fibrinogen C-terminal domain-like, Fibrinogen C-terminal domain-like 2.7Å Yes No
2OYI_C (145741) Fibrinogen gamma chain Parallel coiled-coil, Fibrinogen coiled-coil and central regions, Fibrinogen coiled-coil and central regions 2.7Å No No
2Q9I_C (3180799) Fibrinogen gamma chain Parallel coiled-coil, Fibrinogen coiled-coil and central regions, Fibrinogen coiled-coil and central regions 2.8Å No No
2Q9I_C (3180800) Fibrinogen gamma chain Fibrinogen C-terminal domain-like, Fibrinogen C-terminal domain-like, UNMATCHED 2.8Å No Yes
2XNX_I (4014605) Fibrinogen gamma chain UNMATCHED, UNMATCHED, UNMATCHED 2XNX 3.3Å Yes No
2XNX_F (4014607) Fibrinogen gamma chain UNMATCHED, UNMATCHED, UNMATCHED 2XNX 3.3Å No No
2XNX_C (4014609) Fibrinogen gamma chain UNMATCHED, UNMATCHED, UNMATCHED 2XNX 3.3Å No No
2XNX_L (4014610) Fibrinogen gamma chain UNMATCHED, UNMATCHED, UNMATCHED 2XNX 3.3Å Yes No
2Z4E_C (3280439) Fibrinogen gamma chain Parallel coiled-coil, Fibrinogen coiled-coil and central regions, Fibrinogen coiled-coil and central regions 2.66Å No No
2Z4E_C (3280440) Fibrinogen gamma chain Fibrinogen C-terminal domain-like, Fibrinogen C-terminal domain-like, UNMATCHED 2.66Å Yes No
3BVH_C (155663) Fibrinogen gamma chain Parallel coiled-coil, Fibrinogen coiled-coil and central regions, Fibrinogen coiled-coil and central regions 2.59Å No No
3E1I_C (3370607) Fibrinogen gamma chain Parallel coiled-coil, Fibrinogen coiled-coil and central regions, Fibrinogen coiled-coil and central regions 2.15Å No No
3E1I_C (3370608) Fibrinogen gamma chain Fibrinogen C-terminal domain-like, Fibrinogen C-terminal domain-like, UNMATCHED 2.15Å Yes No
3FIB_A (42455) Fibrinogen gamma chain Fibrinogen C-terminal domain-like, Fibrinogen C-terminal domain-like, Fibrinogen C-terminal domain-like 2.03Å No No
3GHG_C (3430582) Fibrinogen gamma chain UNMATCHED, UNMATCHED, UNMATCHED 3GHG 2.9Å No No
3GHG_C (3430583) Fibrinogen gamma chain Fibrinogen C-terminal domain-like, Fibrinogen C-terminal domain-like, UNMATCHED 2.9Å No No
3H32_F (4177799) Fibrinogen gamma chain UNMATCHED, UNMATCHED, UNMATCHED 3H32 3.6Å No No
3H32_C (4177801) Fibrinogen gamma chain UNMATCHED, UNMATCHED, UNMATCHED 3H32 3.6Å Yes No
3HUS_F (4200512) Fibrinogen gamma chain UNMATCHED, UNMATCHED, UNMATCHED 3HUS 3.04Å No No
3HUS_C (4011899) Fibrinogen gamma chain UNMATCHED, UNMATCHED, UNMATCHED 3HUS 3.04Å Yes Yes
Ligand-based Druggability Score: -0.7
Ligand-based Druggability Score Percentile: 72%
Ligand-based Druggability Help: Help




		
Number of proteins in the network : 13346


FGG is involved in 12 interactions in the network.


Druggability
Overall Druggability Percentile: 91.57
Druggability for Cancer Therapeutics: 76.02
Druggability for Other Therapeutics: 82.86
Cancer-Associated
Cancer-associated percentile : 61.15
Network Articulation Point
Is FGG critical for communication in the network?


Detailed Graph Legend:Help