Molecular Target Synopsis
Overview
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Drugs and Clinical Candidates
Druggability
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RNAi
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Germline Genetics

FGB (P02675) - Druggability - Molecular Target Synopsis

Chain-based assessment (last updated 23/04/2019)
Domain-based assessment (last updated 30/07/2012)


Structural Druggability Help: Help

Chain-based assessment (last updated 23/04/2019)


Chains assessed68
Chains with at least one site assessed as druggable using the strict criteria0
Chains with at least one site assessed as druggable using the relaxed criteria67


		
PDB Chain Protein Name Druggable Relaxed Druggable Strict Details
2HOD_E Fibrinogen beta chain Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2 57 50.6 Yes No
2 bound 2.29 65 29 No No
3 empty 1.69 65.8 14.7 No No
4 empty 2.19 67.3 18.7 No No
5 empty 2.25 77.6 11.3 No No
6 empty 1.98 59.1 9.8 No No
7 empty 1.97 63.2 11.5 No No
8 empty 2.24 59.9 8.4 No No
9 empty 2.33 59.8 9.6 No No
10 empty 1.77 61.4 10.2 No No
2Z4E_B Fibrinogen beta chain Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.96 51.5 50.5 Yes No
2 empty 2.25 67.6 25.1 No No
3 empty 2.29 62.4 26.8 No No
4 empty 2.2 65.6 25.1 No No
5 empty 2.05 64.9 15.8 No No
6 empty 2.06 73.1 11.4 No No
7 empty 2.22 59.1 13.6 No No
8 empty 2.16 55.8 12.2 No No
9 empty 2.31 63.2 13.9 No No
10 empty 2.28 67.9 12.9 No No
2XNX_E Fibrinogen beta chain Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.21 61.5 39.8 Yes No
2 empty 2.07 63.2 31.9 No No
3 empty 2.21 62.5 22.7 No No
4 empty 2.34 69.6 18.2 No No
5 empty 1.86 70.2 12.9 No No
6 empty 1.62 26.3 16.2 No No
7 empty 2.37 62.4 16.7 No No
8 empty 1.33 24.9 11.9 No No
9 empty 2.11 71.9 11.7 No No
10 empty 2.82 61.8 13 No No
3GHG_B Fibrinogen beta chain Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.97 60.9 37.7 Yes No
2 empty 2.09 65 32.2 No No
3 empty 1.81 51.3 24.1 No No
4 empty 1.59 28.1 23.7 No No
5 empty 2.15 68.7 17.6 No No
6 empty 2.34 64.4 22.5 No No
7 empty 2.07 75.1 10.8 No No
8 empty 2.24 60.6 13.9 No No
9 empty 2.1 56.1 15.8 No No
10 empty 2.06 69.1 9.4 No No
1FZG_E Fibrinogen beta chain Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.83 62.4 45.7 Yes No
2 empty 2.11 60.6 31 No No
3 empty 2.12 62.2 21 No No
4 empty 1.59 26.7 23.2 No No
5 empty 2.15 71.3 15.9 No No
6 empty 2.33 62 14.9 No No
7 empty 2.11 62.7 16.3 No No
8 empty 1.87 71.4 11.6 No No
9 empty 1.96 55.1 9.4 No No
10 empty 2.26 53.6 8.8 No No
2HPC_E Fibrinogen beta chain Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.02 54.7 57 Yes No
2 empty 2.33 62.8 27.1 No No
3 empty 2.27 63.5 25.2 No No
4 empty 2.44 72.8 12.6 No No
5 empty 1.63 64.4 13.6 No No
6 empty 2.31 71.6 11.4 No No
7 empty 1.9 61.3 12.5 No No
8 empty 1.71 62.3 9.9 No No
9 empty 2.09 54.7 10 No No
10 empty 2.18 76.3 6.8 No No
1FZE_B Fibrinogen beta chain Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.02 58.6 38.5 Yes No
2 empty 2.27 66.2 33.5 No No
3 empty 2.01 67 29.3 No No
4 empty 2.15 63 24.1 No No
5 empty 1.48 26 22.3 No No
6 empty 2.18 60.1 17 No No
7 empty 1.74 82.1 13.6 No No
8 empty 2.32 65.7 14.6 No No
9 empty 2.36 68.7 10.8 No No
10 empty 1.86 66.1 14.1 No No
1RF1_E Fibrinogen beta chain Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.35 63.8 38.8 Yes No
2 empty 2.25 62.1 22.2 No No
3 empty 2.14 64 20.5 No No
4 empty 1.97 67 17.6 No No
5 empty 1.76 22.6 21.5 No No
6 empty 2.37 58.3 14.5 No No
7 empty 2.43 60.5 12.3 No No
8 empty 1.71 81.2 12.5 No No
9 empty 2.16 53.8 11.4 No No
10 empty 2.08 61.4 15.2 No No
1RF1_B Fibrinogen beta chain Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.74 57.7 56.8 Yes No
2 empty 1.99 66.1 31.9 No No
3 empty 2.04 67.4 13.3 No No
4 empty 2.16 60.1 20.2 No No
5 empty 1.78 76.8 13 No No
6 empty 1.9 57.2 10.9 No No
7 empty 2.11 53.4 11.6 No No
8 empty 2.34 65.1 14.5 No No
9 empty 2.29 64.5 11 No No
10 empty 2.56 68.9 12.3 No No
2Z4E_E Fibrinogen beta chain Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.96 53.4 45.5 Yes No
2 empty 2.04 63.8 41.3 No No
3 empty 2.45 61.8 22.6 No No
4 empty 1.98 67.5 15.8 No No
5 empty 2.25 60.8 14.3 No No
6 empty 2.33 73.6 12.4 No No
7 empty 2.34 64.2 12 No No
8 empty 2.17 68.3 9.8 No No
9 empty 2.14 67.9 12.6 No No
10 empty 2.18 57 8.3 No No
2HPC_B Fibrinogen beta chain Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.33 58.6 44.6 Yes No
2 empty 2.27 64.7 32.1 No No
3 empty 1.83 77.6 14.6 No No
4 empty 2.02 62.1 18.9 No No
5 empty 1.61 25.6 20.5 No No
6 empty 2.4 62.5 13.8 No No
7 empty 2.3 66.6 15.4 No No
8 empty 1.89 59.5 11.3 No No
9 empty 2.37 52.2 10 No No
10 empty 2.24 56.4 9.8 No No
3H32_B Fibrinogen beta chain Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.25 62.1 46.6 Yes No
2 empty 2.05 67.1 25.6 No No
3 empty 2.2 67.8 17.2 No No
4 empty 2.43 65.3 13.3 No No
5 empty 2.01 77.2 12.5 No No
6 empty 1.48 36.1 15.1 No No
7 empty 2.36 54.4 12.5 No No
8 empty 2.01 61.1 15.7 No No
9 empty 1.57 19.3 20.8 No No
10 empty 2.48 59.5 11.2 No No
3GHG_H Fibrinogen beta chain Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.96 61.1 37.7 Yes No
2 empty 1.84 51.1 24.6 No No
3 empty 2.21 71.6 21.2 No No
4 empty 1.91 60.3 18.3 No No
5 empty 1.94 67.5 14.7 No No
6 empty 2.09 69.4 14.1 No No
7 empty 2.26 66 11.8 No No
8 empty 1.48 24.3 17.4 No No
9 empty 1.68 65.1 9.4 No No
10 empty 2.22 50.8 12.2 No No
2HPC_H Fibrinogen beta chain Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.98 61.4 45.3 Yes No
2 empty 2.17 63.3 33.5 No No
3 empty 2.04 63.1 18.8 No No
4 empty 1.68 28 21 No No
5 empty 2.39 62.1 13.3 No No
6 empty 1.95 61.3 12.5 No No
7 empty 2.1 67.1 11.7 No No
8 empty 2.14 51.1 12.9 No No
9 empty 2.08 51.4 9.4 No No
10 empty 2.42 56.2 9.9 No No
1RE3_B Fibrinogen beta chain Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.08 62.3 45.7 Yes No
2 empty 2.02 64.8 28.4 No No
3 empty 1.57 28.2 20.6 No No
4 empty 2.22 64.2 19.2 No No
5 empty 2.08 65.3 16.6 No No
6 empty 2.27 61.2 14.4 No No
7 empty 2.02 74.3 11.3 No No
8 empty 2.35 72.1 9.2 No No
9 empty 2.18 58.9 17 No No
10 empty 2.5 66.9 12.1 No No
1FZC_B Fibrinogen beta chain Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.91 61.7 44.5 Yes No
2 empty 2.29 65.2 18.1 No No
3 empty 2.1 71.9 22.1 No No
4 empty 1.55 28.4 23.1 No No
5 empty 2.09 69.8 14.2 No No
6 empty 2.37 58.7 16.8 No No
7 empty 1.78 85.1 13 Yes No
8 empty 2.3 68.4 12.5 No No
9 empty 2.13 58.9 14.5 No No
10 empty 2.22 62.6 15.7 No No
1RE4_B Fibrinogen beta chain Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.39 54.5 51.4 Yes No
2 empty 1.96 64.8 32.5 No No
3 empty 1.87 68.6 24 No No
4 empty 2.14 60.6 20.3 No No
5 empty 2.16 62.5 21.6 No No
6 empty 1.83 81.6 12.7 No No
7 empty 2.25 61.5 13.2 No No
8 empty 2.58 70.7 9.7 No No
9 empty 2.23 53.4 13.2 No No
10 empty 2.79 56.1 8.3 No No
2HLO_B Fibrinogen beta chain Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.04 58.2 39.5 Yes No
2 empty 2.15 65 32 No No
3 empty 2.04 69.1 21.7 No No
4 empty 1.89 68.6 22.3 No No
5 empty 1.49 30 21.7 No No
6 empty 2.27 66.7 18.4 No No
7 empty 2.31 62.1 13.3 No No
8 empty 2.34 66 17.7 No No
9 empty 2.28 74.2 10.1 No No
10 empty 2.29 68 11 No No
1FZF_B Fibrinogen beta chain Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.04 61.8 44.1 Yes No
2 empty 2.1 67.4 26 No No
3 empty 2.37 58.1 22.1 No No
4 empty 1.99 67.4 18.2 No No
5 empty 2.27 73.1 13.9 No No
6 empty 2.41 57.7 15.2 No No
7 empty 2.21 70.2 17.3 No No
8 empty 1.54 25.5 17.5 No No
9 empty 2.35 66.7 13.5 No No
10 empty 1.72 54.7 9.8 No No
2HOD_K Fibrinogen beta chain Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.93 61.4 44.4 Yes No
2 empty 2.31 65 27.6 No No
3 empty 1.62 28.2 16.9 No No
4 empty 1.73 66 14.6 No No
5 empty 2.24 75.9 12.3 No No
6 empty 2.28 65.8 11.7 No No
7 empty 2.13 69.1 13.6 No No
8 empty 2.31 49.8 9.3 No No
9 empty 2.07 59.9 8.3 No No
10 empty 1.77 58.7 10.2 No No
1LTJ_E Fibrinogen beta chain Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.94 55.7 45.1 Yes No
2 empty 2.16 65 32 No No
3 empty 2.22 70.3 20.3 No No
4 empty 1.99 66 13.6 No No
5 empty 2.27 62.2 17.7 No No
6 empty 1.83 79.7 12.2 No No
7 empty 2.44 61 12.2 No No
8 empty 2.27 59.5 18.8 No No
9 empty 2.15 61.8 17.2 No No
10 empty 2.19 55.4 11 No No
2FFD_E Fibrinogen beta chain Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.97 58.6 54.7 Yes No
2 empty 2.1 75.2 13.7 No No
3 empty 2.1 62.5 21.7 No No
4 empty 2.12 67 13.3 No No
5 empty 1.7 75.8 13.8 No No
6 empty 2.25 53.2 12 No No
7 empty 2.07 61.7 18.2 No No
8 empty 2.28 59.9 13.2 No No
9 empty 2.28 56 11.2 No No
10 empty 2.14 67.5 15 No No
2H43_E Fibrinogen beta chain Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.9 60.9 37.4 Yes No
2 empty 2.01 65.8 30 No No
3 empty 2.43 62.3 22.5 No No
4 empty 1.69 28 26 No No
5 empty 2.01 67.8 18.6 No No
6 empty 2.25 57 17.2 No No
7 empty 2.51 66 13.3 No No
8 empty 1.94 81 14.2 No No
9 empty 2.33 72.5 12.9 No No
10 empty 2.31 63.8 13.7 No No
1FZA_E Fibrinogen beta chain Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.07 60.7 43.9 Yes No
2 empty 2.07 68.7 25.5 No No
3 empty 1.43 31.5 21.4 No No
4 empty 2.63 71.1 16.1 No No
5 empty 2.46 67 20.8 No No
6 empty 1.88 80.6 12.2 No No
7 empty 2.32 63.2 19.6 No No
8 empty 2.11 74.1 8.8 No No
9 empty 2.14 63.5 15.5 No No
10 empty 2.66 60.9 10.5 No No
3H32_E Fibrinogen beta chain Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.21 59.2 49.1 Yes No
2 empty 2.16 65.1 21.1 No No
3 empty 2.09 69.9 13.3 No No
4 empty 2.35 65.8 14.3 No No
5 empty 2.05 77.3 13.4 No No
6 empty 1.94 61.7 15.4 No No
7 empty 2.2 54.9 11.6 No No
8 empty 1.32 20.7 12.9 No No
9 empty 2.42 60.1 12.5 No No
10 empty 2.49 63.9 10.7 No No
2XNY_B Fibrinogen beta chain Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.11 55.2 54.9 Yes No
2 empty 1.98 65.7 30 No No
3 empty 2.27 65.3 21.1 No No
4 empty 1.92 78.3 13.6 No No
5 empty 2.18 61.3 14.5 No No
6 empty 2.1 69.7 12.1 No No
7 empty 2.2 75.1 13.6 No No
8 empty 2.23 62.7 19.4 No No
9 empty 2.42 70.6 9.1 No No
10 empty 2.69 53.1 11.4 No No
1FZC_E Fibrinogen beta chain Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.97 62 44.5 Yes No
2 empty 2.21 71.2 19.6 No No
3 empty 2.1 66.8 14.7 No No
4 empty 2.39 63.8 13.4 No No
5 empty 1.56 22 20.8 No No
6 empty 2.08 61.2 14.7 No No
7 empty 2.3 64 15.1 No No
8 empty 1.75 85.9 12.8 Yes No
9 empty 2.17 59.3 11.9 No No
10 empty 2.24 55.3 14.2 No No
2XNX_B Fibrinogen beta chain Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.1 60.5 40.3 Yes No
2 empty 1.99 61.7 23.2 No No
3 empty 2.7 64.9 24.5 No No
4 empty 2.17 59.7 22.4 No No
5 empty 2.19 63.2 25.9 No No
6 empty 1.66 28.4 24.9 No No
7 empty 2.29 72.6 15.5 No No
8 empty 2.15 66.5 11.8 No No
9 empty 2.27 47.5 11 No No
10 empty 2.69 61.7 13.3 No No
2OYH_B Fibrinogen beta chain Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.92 58.3 40.8 Yes No
2 empty 1.99 68.1 33.2 No No
3 empty 2.22 73.8 16.6 No No
4 empty 1.71 27.4 21 No No
5 empty 2.08 69.4 12.4 No No
6 empty 2.47 60.8 22.7 No No
7 empty 1.81 77.8 13.8 No No
8 empty 2.29 60.1 14.9 No No
9 empty 2.03 55.3 11.9 No No
10 empty 2.32 62.8 10.6 No No
2Q9I_E Fibrinogen beta chain Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.85 61.6 50.9 Yes No
2 empty 2.01 66.3 43.6 No No
3 empty 1.5 25.6 23.4 No No
4 empty 2.03 68.8 13.3 No No
5 empty 2.19 56.6 11.5 No No
6 empty 2.43 69.6 8.4 No No
7 empty 1.97 63.6 17.4 No No
8 empty 2.25 59.3 11.4 No No
9 empty 2.11 61.3 9.2 No No
10 empty 2.09 58.6 9.2 No No
2HOD_B Fibrinogen beta chain Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.86 63.1 47.1 Yes No
2 empty 2.33 65 27.8 No No
3 empty 1.86 67.6 15.8 No No
4 empty 1.67 25.5 15.7 No No
5 empty 2.03 58.5 14.2 No No
6 empty 2.25 64.8 12.3 No No
7 empty 2.2 66.8 10 No No
8 empty 2.36 52.3 10 No No
9 empty 2.18 63.5 13.6 No No
10 empty 2.27 60.6 7.8 No No
1N86_E Fibrinogen beta chain Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2 58 34.6 Yes No
2 empty 2.11 63.8 31.3 No No
3 empty 2.2 69 25.3 No No
4 empty 2.12 63.3 25.6 No No
5 empty 2.14 67.8 20.4 No No
6 empty 1.62 27.8 22.1 No No
7 empty 2.01 60.4 11.2 No No
8 empty 1.88 59.7 11.8 No No
9 empty 2.21 59.1 11.4 No No
10 empty 2.47 61.7 9.5 No No
2FFD_B Fibrinogen beta chain Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.97 58.4 40.3 Yes No
2 empty 1.98 68.7 32.2 No No
3 empty 2.16 73.1 19.9 No No
4 empty 1.74 28.5 25.8 No No
5 empty 2.02 67.6 13.1 No No
6 empty 2.15 60.8 21.5 No No
7 empty 1.84 79.7 13.5 No No
8 empty 2.34 60.7 14.2 No No
9 empty 2.05 64.8 18.8 No No
10 empty 2.34 58.3 12.8 No No
2XNX_K Fibrinogen beta chain Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.08 62.1 47.5 Yes No
2 empty 2.38 68.7 28.5 No No
3 empty 1.92 66.4 18.1 No No
4 empty 2.28 70.3 14.5 No No
5 empty 2.26 58.6 12.8 No No
6 empty 2.08 71.1 9.4 No No
7 empty 1.37 26.8 13 No No
8 empty 2.78 58.1 13.2 No No
9 empty 2.27 48 10.8 No No
10 empty 2.56 62.6 12.1 No No
1RE4_E Fibrinogen beta chain Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.85 54.6 52.3 Yes No
2 empty 1.99 65.9 32.4 No No
3 empty 1.77 71.5 18.1 No No
4 empty 2.06 61 18.7 No No
5 empty 2.03 61.9 17 No No
6 empty 1.86 81.8 13.1 No No
7 empty 2.34 71.3 8.9 No No
8 empty 2.23 59.5 19.4 No No
9 empty 2.49 63.5 12.3 No No
10 empty 2.3 62.5 8.3 No No
3E1I_B Fibrinogen beta chain Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.13 55.2 55.4 Yes No
2 empty 1.97 64.1 29.1 No No
3 empty 2.15 63.2 17.2 No No
4 empty 1.9 78.1 13.6 No No
5 empty 2.1 70.2 11 No No
6 empty 2.28 65.1 13.4 No No
7 empty 2.21 59.5 10.9 No No
8 empty 2.5 70 9.1 No No
9 empty 2.16 62.7 8.3 No No
10 empty 2.65 54.1 9.7 No No
3GHG_E Fibrinogen beta chain Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.9 60.7 45.2 Yes No
2 empty 1.85 53.1 25.7 No No
3 empty 1.95 67.6 13 No No
4 empty 2.46 61.1 17.2 No No
5 empty 2.02 71.2 13.2 No No
6 empty 1.93 76.9 11.6 No No
7 empty 1.84 25.9 14.7 No No
8 empty 2.27 72.2 11.8 No No
9 empty 1.82 58.1 9.3 No No
10 empty 2.1 52.6 11.9 No No
2Q9I_B Fibrinogen beta chain Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.9 52.3 50.3 Yes No
2 empty 2.29 63.9 26.5 No No
3 empty 2.22 62.4 23.4 No No
4 empty 2.15 64.2 22.8 No No
5 empty 2.05 69.9 16.5 No No
6 empty 2.06 65.6 18.8 No No
7 empty 2.22 59 13.7 No No
8 empty 2.19 54.7 12.4 No No
9 empty 2.47 68.6 12.2 No No
10 empty 1.96 68.7 13.9 No No
2XNY_E Fibrinogen beta chain Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.07 52.7 55.5 Yes No
2 empty 2.12 67 31.6 No No
3 empty 1.99 64.8 29.7 No No
4 empty 2.15 66.7 18.4 No No
5 empty 1.96 77.3 13.3 No No
6 empty 2.29 61.9 13.8 No No
7 empty 2.11 66 11.5 No No
8 empty 2.25 73.7 11.5 No No
9 empty 2.37 62.5 16.6 No No
10 empty 2.62 66.7 13 No No
1RF0_E Fibrinogen beta chain Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.87 59.1 36.1 Yes No
2 empty 2.04 65.3 33.8 No No
3 empty 2.03 76 15.9 No No
4 empty 2.09 61.9 24.1 No No
5 empty 1.81 27 23.8 No No
6 empty 2.26 62.7 22 No No
7 empty 1.75 82.4 14 No No
8 empty 2.4 60.9 13.7 No No
9 empty 2.26 69.9 11.2 No No
10 empty 2.33 59.3 19.6 No No
2H43_B Fibrinogen beta chain Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.96 56.1 45 Yes No
2 empty 2.01 65.3 31.8 No No
3 empty 2.01 69.4 13.3 No No
4 empty 1.64 27.2 21.3 No No
5 empty 2.16 71.4 11.9 No No
6 empty 2.15 56.7 15.8 No No
7 empty 2.28 60.1 14.8 No No
8 empty 2.41 73.2 11.9 No No
9 empty 2.09 81.6 11.8 No No
10 empty 2.21 56.5 11.1 No No
1FZA_B Fibrinogen beta chain Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.08 59.3 36.9 Yes No
2 bound 2.07 64.7 25.7 No No
3 empty 2.02 65.3 33.9 No No
4 empty 1.43 29 21.7 No No
5 empty 2.61 69.7 13.4 No No
6 empty 2.5 65.8 18.3 No No
7 empty 1.89 81 12.3 No No
8 empty 2.39 58.8 15.2 No No
9 empty 2.29 63.5 14.5 No No
10 empty 2.04 75.2 11.9 No No
1LT9_E Fibrinogen beta chain Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.83 58.4 37.1 Yes No
2 empty 2.09 64.8 33.2 No No
3 empty 1.86 72 19.7 No No
4 empty 1.57 28.1 21.4 No No
5 empty 2.05 61.6 19.1 No No
6 empty 2.1 60.2 18.6 No No
7 empty 1.79 79.3 12.5 No No
8 empty 2.46 63.6 12.7 No No
9 empty 2.18 72.3 11 No No
10 empty 2.22 60.2 18.1 No No
2A45_H Fibrinogen beta chain No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.99 54 19.1 No No
2 empty 2.85 54.4 12.7 No No
3 empty 1.95 52.2 12.1 No No
4 empty 2.79 66.4 6 No No
5 empty 3.81 66.7 5 No No
6 empty 2.09 47.9 6.8 No No
7 empty 2.81 70.2 0 No No
8 empty 3.09 58.8 6.7 No No
9 empty 2.55 42.4 6.3 No No
2A45_K Fibrinogen beta chain Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.86 51.2 24.1 Yes No
2 empty 2.64 55.2 14.9 No No
3 empty 2.31 59.3 7.7 No No
4 empty 1.92 54.9 8.8 No No
5 empty 3.56 68.9 5.4 No No
6 empty 3.31 43.6 5.8 No No
3E1I_E Fibrinogen beta chain Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.95 61.6 37.4 Yes No
2 empty 1.76 64.1 31.1 No No
3 empty 2.13 65.9 30.7 No No
4 empty 1.58 26.1 24.9 No No
5 empty 2.08 66 14.4 No No
6 empty 1.96 77.2 15 No No
7 empty 2.27 61 16.4 No No
8 empty 2.28 58.8 13.7 No No
9 empty 2.22 57.7 17.8 No No
10 empty 1.84 67.4 11.4 No No
1LTJ_B Fibrinogen beta chain Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.88 62.9 44.1 Yes No
2 empty 2.18 70.5 24.5 No No
3 empty 1.74 27.4 25.5 No No
4 empty 2.13 66.9 11.7 No No
5 empty 2.17 65.1 17.3 No No
6 empty 1.82 78.5 13.1 No No
7 empty 2.06 52.5 12.1 No No
8 empty 2.25 63.1 18.3 No No
9 empty 1.97 55.5 13.3 No No
10 empty 2.18 60.3 11.2 No No
2HLO_E Fibrinogen beta chain Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.03 56.5 46.3 Yes No
2 empty 2.27 60.7 29.1 No No
3 empty 2.05 67.1 24.2 No No
4 empty 2.12 62 22.8 No No
5 empty 1.99 73.9 18.5 No No
6 empty 2.22 74.3 12.9 No No
7 empty 2.28 59.1 13.7 No No
8 empty 2.35 63.9 13.4 No No
9 empty 2.22 69.6 11.1 No No
10 empty 1.34 22.2 13 No No
2XNX_H Fibrinogen beta chain Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.91 50.9 28 Yes No
2 empty 2.31 66.2 35 No No
3 empty 2.03 66.9 33.9 No No
4 empty 2.26 67.8 26.2 No No
5 empty 2.27 66.6 19.6 No No
6 empty 1.59 23.4 23.3 No No
7 empty 2.19 65.6 18.9 No No
8 empty 1.93 72.9 12.4 No No
9 empty 2.15 59.8 13.7 No No
10 empty 2.18 73.1 9.9 No No
2HPC_K Fibrinogen beta chain Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.08 60.5 46.8 Yes No
2 empty 1.57 30.6 21.7 No No
3 empty 2.08 64.7 20.5 No No
4 empty 2.45 78.1 11.2 No No
5 empty 2.36 66.7 20.4 No No
6 empty 1.62 62.9 13.9 No No
7 empty 2.32 58.4 17.2 No No
8 empty 2.01 64.7 13.8 No No
9 empty 2.33 71.6 12.1 No No
10 empty 2.4 55.3 13.2 No No
3HUS_E Fibrinogen beta chain Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.92 59.5 38.3 Yes No
2 empty 2.02 66.2 31.7 No No
3 empty 2.22 64.6 19.1 No No
4 empty 1.9 62.7 17.8 No No
5 empty 1.64 28.2 21.3 No No
6 empty 2.37 73.7 12.7 No No
7 empty 2.42 73.4 13.5 No No
8 empty 2.45 64.4 14.4 No No
9 empty 1.93 61.2 11.7 No No
10 empty 2.17 61.2 13.9 No No
1FZB_E Fibrinogen beta chain Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.22 59.4 36.7 Yes No
2 empty 1.79 64.2 29.1 No No
3 empty 2.11 62.8 22 No No
4 empty 2.1 71.9 16.5 No No
5 empty 1.51 27.4 17.2 No No
6 empty 2.25 54.6 22.6 No No
7 empty 2.34 58.4 15 No No
8 empty 2.08 61 14.8 No No
9 empty 2.06 74.2 9.8 No No
10 empty 2.27 67.7 10.7 No No
2OYI_E Fibrinogen beta chain Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.83 51.1 47.7 Yes No
2 empty 2.07 63.7 33.2 No No
3 empty 2.26 70.4 16.5 No No
4 empty 2.06 67.2 18.6 No No
5 empty 2.24 65.4 22.9 No No
6 empty 2.38 63.2 12.4 No No
7 empty 1.73 79.5 14.1 No No
8 empty 2.31 57.3 14.8 No No
9 empty 1.85 57.3 11.1 No No
10 empty 2.34 58.1 13.1 No No
1FZB_B Fibrinogen beta chain Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.2 60.2 36 Yes No
2 empty 1.87 65.5 32.2 No No
3 empty 1.99 64.1 34.3 No No
4 empty 2.19 63.1 18.1 No No
5 empty 1.44 28.3 21.1 No No
6 empty 2.41 59.3 13.7 No No
7 empty 2.13 72.2 10.2 No No
8 empty 2.31 64.1 16.1 No No
9 empty 2.15 64.2 9.2 No No
10 empty 2.77 53.3 8.7 No No
2OYH_E Fibrinogen beta chain Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.94 56.2 45.2 Yes No
2 empty 2.21 62.4 22.4 No No
3 empty 2.2 73.9 19.3 No No
4 empty 1.99 67.6 14.8 No No
5 empty 2.19 64.1 21.1 No No
6 empty 2.38 64.5 10.9 No No
7 empty 2.15 64 17.2 No No
8 empty 1.64 81.7 13.1 No No
9 empty 2.05 54.5 11.4 No No
10 empty 2.32 56 13.3 No No
1FZE_E Fibrinogen beta chain Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.09 59.1 38.5 Yes No
2 empty 2.2 66.2 30.6 No No
3 empty 1.98 66.6 28.6 No No
4 empty 2.18 65.5 22.2 No No
5 empty 1.5 23.1 22.8 No No
6 empty 2.19 58.9 13.9 No No
7 empty 1.75 79.4 12.7 No No
8 empty 2.34 68.4 12 No No
9 empty 2.22 62.6 14 No No
10 empty 2.26 65.8 13.5 No No
2HOD_H Fibrinogen beta chain Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.69 63.4 46.4 Yes No
2 empty 2.34 67.4 25.1 No No
3 empty 1.86 66.2 15.5 No No
4 empty 1.67 25.8 20.4 No No
5 empty 1.98 60.2 14.9 No No
6 empty 2.39 63 12.1 No No
7 empty 2.26 59.2 12.1 No No
8 empty 2.24 54.5 11.3 No No
9 empty 2.22 61.6 10.7 No No
10 empty 2.21 55.5 9.9 No No
3GHG_K Fibrinogen beta chain Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.95 56.3 45.7 Yes No
2 empty 2.06 65.3 34.4 No No
3 empty 1.86 55.1 22.7 No No
4 empty 2.31 70 21.9 No No
5 empty 1.93 69.3 12 No No
6 empty 2.08 73.4 11.7 No No
7 empty 1.98 57.5 16.8 No No
8 empty 1.97 60.7 15.8 No No
9 empty 2.27 55.6 11 No No
10 empty 2.86 50.6 13.7 No No
3HUS_B Fibrinogen beta chain Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.07 60.9 45.2 Yes No
2 empty 1.83 68.9 19.3 No No
3 empty 1.88 71.3 19.6 No No
4 empty 2.04 67.8 14.9 No No
5 empty 1.68 23.4 21.1 No No
6 empty 2.18 76.8 12.6 No No
7 empty 2.09 63.2 17.4 No No
8 empty 2.26 62.2 13.6 No No
9 empty 2.21 59.5 14 No No
10 empty 2.33 63.8 12.8 No No
1RE3_E Fibrinogen beta chain Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.01 59.3 37 Yes No
2 empty 2.13 64.3 32 No No
3 empty 1.82 66.6 29.1 No No
4 empty 1.54 28.4 22.3 No No
5 empty 2.15 63 18.3 No No
6 empty 2.2 63.8 20.4 No No
7 empty 1.91 85.1 12.9 Yes No
8 empty 2.24 73.4 11.3 No No
9 empty 2.22 59.8 18.5 No No
10 empty 2.14 68.5 12 No No
3BVH_E Fibrinogen beta chain Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.96 52 51.5 Yes No
2 empty 2.03 65.4 31 No No
3 empty 2.19 69.3 24.8 No No
4 empty 2.04 69.1 16.4 No No
5 empty 2.47 63.8 18.4 No No
6 empty 2.3 62.2 12.6 No No
7 empty 2.01 84.2 12.4 No No
8 empty 2.22 56.3 11.3 No No
9 empty 2.24 61.3 19.2 No No
10 empty 1.93 51.8 10.9 No No
1FZG_B Fibrinogen beta chain Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.84 60.7 37.3 Yes No
2 empty 2.09 66.7 32.1 No No
3 empty 2.2 64 23.1 No No
4 empty 2.07 70.5 17 No No
5 empty 1.57 30 21.4 No No
6 empty 1.99 65.1 17.2 No No
7 empty 2.25 52.8 18.4 No No
8 empty 1.95 65.7 18.5 No No
9 empty 2.3 66.7 10.8 No No
10 empty 2.12 57.6 12.9 No No
3BVH_B Fibrinogen beta chain Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.92 58.2 51.6 Yes No
2 empty 2.14 70.4 16.6 No No
3 empty 2.58 61.4 22.7 No No
4 empty 2.08 67.6 17.9 No No
5 empty 1.91 75.7 14.2 No No
6 empty 2.24 60.5 13 No No
7 empty 2.2 60.5 13.4 No No
8 empty 2.32 66.6 17.6 No No
9 empty 1.92 59.7 10.1 No No
10 empty 2.27 54.9 12.7 No No
1LT9_B Fibrinogen beta chain Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.9 59.4 37.7 Yes No
2 empty 1.97 64.5 32.3 No No
3 empty 1.88 66 28.8 No No
4 empty 1.62 29.2 22.2 No No
5 empty 2.14 64.8 18.1 No No
6 empty 1.84 77.5 13.1 No No
7 empty 2.25 64.3 17 No No
8 empty 2.29 61.8 15.4 No No
9 empty 2.25 68.4 11.1 No No
10 empty 2.22 62.5 19.2 No No
1N86_B Fibrinogen beta chain Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.06 59.9 35.4 Yes No
2 empty 2.11 66.7 33 No No
3 empty 2.17 67.4 30.5 No No
4 empty 2.18 64.2 23.3 No No
5 empty 1.58 28.6 21 No No
6 empty 2.14 71.3 12.1 No No
7 empty 2.2 78.4 10.6 No No
8 empty 2.04 54 11.3 No No
9 empty 2.31 60.5 18 No No
10 empty 2.15 53.6 10.4 No No
1FZF_E Fibrinogen beta chain Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.03 63.1 44 Yes No
2 empty 2.38 65.2 23.3 No No
3 empty 2.45 57.7 20.6 No No
4 empty 1.95 66.2 18.2 No No
5 empty 2.33 75.9 13.1 No No
6 empty 1.55 25.4 21 No No
7 empty 2.25 58.8 14.5 No No
8 empty 2.07 67.5 18.1 No No
9 empty 2.28 62.7 11.9 No No
10 empty 1.77 58 8.9 No No
1RF0_B Fibrinogen beta chain Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.95 60.6 39.2 Yes No
2 empty 1.99 65.3 31.6 No No
3 empty 2.11 65.1 28.1 No No
4 empty 1.76 30.7 23.8 No No
5 empty 2.2 63.7 18.1 No No
6 empty 2.14 60.1 16.1 No No
7 empty 1.87 85.8 13 Yes No
8 empty 2.23 63.8 14.1 No No
9 empty 2.31 60.6 18 No No
10 empty 2.12 60.5 12.2 No No
2OYI_B Fibrinogen beta chain Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.92 55.5 57.6 Yes No
2 empty 1.98 65 31 No No
3 empty 2.04 65.3 16.1 No No
4 empty 1.62 81.1 12.7 No No
5 empty 2.26 62.5 18.9 No No
6 empty 2.25 61.8 18.3 No No
7 empty 2.11 53.7 12.1 No No
8 empty 1.78 57.6 10.9 No No
9 empty 2.22 61.6 9.2 No No
10 empty 2.65 69.3 9 No No

Domain-based assessment (last updated 30/07/2012)


Domains assessed68
Domains assessed as druggable using the strict criteria1
Domains assessed as druggable using the relaxed criteria38

PDB (Domain) Protein Name Domain Resolution Ligands Druggable Relaxed Druggable Strict
1FZA_E (45624) Fibrinogen beta chain Parallel coiled-coil, Fibrinogen coiled-coil and central regions, Fibrinogen coiled-coil and central regions 2.9Å No No
1FZA_E (42482) Fibrinogen beta chain Fibrinogen C-terminal domain-like, Fibrinogen C-terminal domain-like, Fibrinogen C-terminal domain-like 2.9Å Yes Yes
1FZA_B (42480) Fibrinogen beta chain Fibrinogen C-terminal domain-like, Fibrinogen C-terminal domain-like, Fibrinogen C-terminal domain-like 2.9Å Yes No
1FZA_B (45621) Fibrinogen beta chain Parallel coiled-coil, Fibrinogen coiled-coil and central regions, Fibrinogen coiled-coil and central regions 2.9Å No No
1FZB_B (45609) Fibrinogen beta chain Parallel coiled-coil, Fibrinogen coiled-coil and central regions, Fibrinogen coiled-coil and central regions 2.9Å No No
1FZB_E (45612) Fibrinogen beta chain Parallel coiled-coil, Fibrinogen coiled-coil and central regions, Fibrinogen coiled-coil and central regions 2.9Å No No
1FZB_E (42474) Fibrinogen beta chain Fibrinogen C-terminal domain-like, Fibrinogen C-terminal domain-like, Fibrinogen C-terminal domain-like 2.9Å Yes No
1FZB_B (42472) Fibrinogen beta chain Fibrinogen C-terminal domain-like, Fibrinogen C-terminal domain-like, Fibrinogen C-terminal domain-like 2.9Å Yes No
1FZC_B (45591) Fibrinogen beta chain Parallel coiled-coil, Fibrinogen coiled-coil and central regions, Fibrinogen coiled-coil and central regions 2.3Å No No
1FZC_B (42460) Fibrinogen beta chain Fibrinogen C-terminal domain-like, Fibrinogen C-terminal domain-like, Fibrinogen C-terminal domain-like 2.3Å Yes No
1FZC_E (45594) Fibrinogen beta chain Parallel coiled-coil, Fibrinogen coiled-coil and central regions, Fibrinogen coiled-coil and central regions 2.3Å No No
1FZC_E (42462) Fibrinogen beta chain Fibrinogen C-terminal domain-like, Fibrinogen C-terminal domain-like, Fibrinogen C-terminal domain-like 2.3Å Yes No
1FZE_B (42476) Fibrinogen beta chain Fibrinogen C-terminal domain-like, Fibrinogen C-terminal domain-like, Fibrinogen C-terminal domain-like 3Å No No
1FZE_E (42478) Fibrinogen beta chain Fibrinogen C-terminal domain-like, Fibrinogen C-terminal domain-like, Fibrinogen C-terminal domain-like 3Å Yes No
1FZE_B (45615) Fibrinogen beta chain Parallel coiled-coil, Fibrinogen coiled-coil and central regions, Fibrinogen coiled-coil and central regions 3Å No No
1FZE_E (45618) Fibrinogen beta chain Parallel coiled-coil, Fibrinogen coiled-coil and central regions, Fibrinogen coiled-coil and central regions 3Å No No
1FZF_B (45597) Fibrinogen beta chain Parallel coiled-coil, Fibrinogen coiled-coil and central regions, Fibrinogen coiled-coil and central regions 2.7Å No No
1FZF_E (42466) Fibrinogen beta chain Fibrinogen C-terminal domain-like, Fibrinogen C-terminal domain-like, Fibrinogen C-terminal domain-like 2.7Å Yes No
1FZF_B (42464) Fibrinogen beta chain Fibrinogen C-terminal domain-like, Fibrinogen C-terminal domain-like, Fibrinogen C-terminal domain-like 2.7Å Yes No
1FZF_E (45600) Fibrinogen beta chain Parallel coiled-coil, Fibrinogen coiled-coil and central regions, Fibrinogen coiled-coil and central regions 2.7Å No No
1FZG_B (45603) Fibrinogen beta chain Parallel coiled-coil, Fibrinogen coiled-coil and central regions, Fibrinogen coiled-coil and central regions 2.5Å No No
1FZG_E (45606) Fibrinogen beta chain Parallel coiled-coil, Fibrinogen coiled-coil and central regions, Fibrinogen coiled-coil and central regions 2.5Å No No
1FZG_E (42470) Fibrinogen beta chain Fibrinogen C-terminal domain-like, Fibrinogen C-terminal domain-like, Fibrinogen C-terminal domain-like 2.5Å Yes No
1FZG_B (42468) Fibrinogen beta chain Fibrinogen C-terminal domain-like, Fibrinogen C-terminal domain-like, Fibrinogen C-terminal domain-like 2.5Å Yes No
1LT9_B (78189) Fibrinogen beta chain Fibrinogen C-terminal domain-like, Fibrinogen C-terminal domain-like, Fibrinogen C-terminal domain-like 2.8Å Yes No
1LT9_B (78190) Fibrinogen beta chain Parallel coiled-coil, Fibrinogen coiled-coil and central regions, Fibrinogen coiled-coil and central regions 2.8Å No No
1LT9_E (78195) Fibrinogen beta chain Parallel coiled-coil, Fibrinogen coiled-coil and central regions, Fibrinogen coiled-coil and central regions 2.8Å No No
1LT9_E (78194) Fibrinogen beta chain Fibrinogen C-terminal domain-like, Fibrinogen C-terminal domain-like, Fibrinogen C-terminal domain-like 2.8Å Yes No
1LTJ_B (78199) Fibrinogen beta chain Fibrinogen C-terminal domain-like, Fibrinogen C-terminal domain-like, Fibrinogen C-terminal domain-like 2.8Å Yes No
1LTJ_E (78204) Fibrinogen beta chain Fibrinogen C-terminal domain-like, Fibrinogen C-terminal domain-like, Fibrinogen C-terminal domain-like 2.8Å Yes No
1LTJ_B (78200) Fibrinogen beta chain Parallel coiled-coil, Fibrinogen coiled-coil and central regions, Fibrinogen coiled-coil and central regions 2.8Å No No
1LTJ_E (78205) Fibrinogen beta chain Parallel coiled-coil, Fibrinogen coiled-coil and central regions, Fibrinogen coiled-coil and central regions 2.8Å No No
1N86_B (80278) Fibrinogen beta chain Fibrinogen C-terminal domain-like, Fibrinogen C-terminal domain-like, Fibrinogen C-terminal domain-like 3.1Å Yes No
1N86_B (80279) Fibrinogen beta chain Parallel coiled-coil, Fibrinogen coiled-coil and central regions, Fibrinogen coiled-coil and central regions 3.1Å No No
1N86_E (80283) Fibrinogen beta chain Fibrinogen C-terminal domain-like, Fibrinogen C-terminal domain-like, Fibrinogen C-terminal domain-like 3.1Å Yes No
1N86_E (80284) Fibrinogen beta chain Parallel coiled-coil, Fibrinogen coiled-coil and central regions, Fibrinogen coiled-coil and central regions 3.1Å No No
1RE3_E (104897) Fibrinogen beta chain Fibrinogen C-terminal domain-like, Fibrinogen C-terminal domain-like, Fibrinogen C-terminal domain-like 2.45Å Yes No
1RE3_B (104892) Fibrinogen beta chain Fibrinogen C-terminal domain-like, Fibrinogen C-terminal domain-like, Fibrinogen C-terminal domain-like 2.45Å Yes No
1RE3_E (104898) Fibrinogen beta chain Parallel coiled-coil, Fibrinogen coiled-coil and central regions, Fibrinogen coiled-coil and central regions 2.45Å No No
1RE4_B (104903) Fibrinogen beta chain Parallel coiled-coil, Fibrinogen coiled-coil and central regions, Fibrinogen coiled-coil and central regions 2.7Å No No
1RE4_E (104907) Fibrinogen beta chain Fibrinogen C-terminal domain-like, Fibrinogen C-terminal domain-like, Fibrinogen C-terminal domain-like 2.7Å Yes No
1RE4_E (104908) Fibrinogen beta chain Parallel coiled-coil, Fibrinogen coiled-coil and central regions, Fibrinogen coiled-coil and central regions 2.7Å No No
1RE4_B (104902) Fibrinogen beta chain Fibrinogen C-terminal domain-like, Fibrinogen C-terminal domain-like, Fibrinogen C-terminal domain-like 2.7Å Yes No
1RF0_B (97340) Fibrinogen beta chain Parallel coiled-coil, Fibrinogen coiled-coil and central regions, Fibrinogen coiled-coil and central regions 2.8Å No No
1RF0_B (97339) Fibrinogen beta chain Fibrinogen C-terminal domain-like, Fibrinogen C-terminal domain-like, Fibrinogen C-terminal domain-like 2.8Å Yes No
1RF0_E (97344) Fibrinogen beta chain Fibrinogen C-terminal domain-like, Fibrinogen C-terminal domain-like, Fibrinogen C-terminal domain-like 2.8Å Yes No
1RF0_E (97345) Fibrinogen beta chain Parallel coiled-coil, Fibrinogen coiled-coil and central regions, Fibrinogen coiled-coil and central regions 2.8Å No No
1RF1_E (97354) Fibrinogen beta chain Fibrinogen C-terminal domain-like, Fibrinogen C-terminal domain-like, Fibrinogen C-terminal domain-like 2.53Å Yes No
1RF1_B (97349) Fibrinogen beta chain Fibrinogen C-terminal domain-like, Fibrinogen C-terminal domain-like, Fibrinogen C-terminal domain-like 2.53Å Yes No
1RF1_B (97350) Fibrinogen beta chain Parallel coiled-coil, Fibrinogen coiled-coil and central regions, Fibrinogen coiled-coil and central regions 2.53Å No No
1RF1_E (97355) Fibrinogen beta chain Parallel coiled-coil, Fibrinogen coiled-coil and central regions, Fibrinogen coiled-coil and central regions 2.53Å No No
2A45_H (3040131) Fibrinogen beta chain PFAM, PFAM, PFAM Fib_beta 3.65Å No No
2Q9I_B (3180798) Fibrinogen beta chain Fibrinogen C-terminal domain-like, Fibrinogen C-terminal domain-like, UNMATCHED 2.8Å Yes No
2Q9I_B (3180797) Fibrinogen beta chain PFAM, PFAM, PFAM Fib_beta 2.8Å No No
2XNX_B (4014602) Fibrinogen beta chain UNMATCHED, UNMATCHED, UNMATCHED 2XNX 3.3Å Yes No
2XNX_H (4014603) Fibrinogen beta chain UNMATCHED, UNMATCHED, UNMATCHED 2XNX 3.3Å Yes No
2XNX_E (4014600) Fibrinogen beta chain UNMATCHED, UNMATCHED, UNMATCHED 2XNX 3.3Å Yes No
2XNX_K (4014599) Fibrinogen beta chain UNMATCHED, UNMATCHED, UNMATCHED 2XNX 3.3Å Yes No
2Z4E_B (3280438) Fibrinogen beta chain Fibrinogen C-terminal domain-like, Fibrinogen C-terminal domain-like, UNMATCHED 2.66Å Yes No
2Z4E_B (3280437) Fibrinogen beta chain Parallel coiled-coil, Fibrinogen coiled-coil and central regions, Fibrinogen coiled-coil and central regions 2.66Å No No
3E1I_B (3370605) Fibrinogen beta chain UNMATCHED, UNMATCHED, UNMATCHED 3E1I 2.15Å No No
3E1I_B (3370606) Fibrinogen beta chain Fibrinogen C-terminal domain-like, Fibrinogen C-terminal domain-like, UNMATCHED 2.15Å Yes No
3GHG_B (3430581) Fibrinogen beta chain Fibrinogen C-terminal domain-like, Fibrinogen C-terminal domain-like, UNMATCHED 2.9Å Yes No
3GHG_B (3430580) Fibrinogen beta chain UNMATCHED, UNMATCHED, UNMATCHED 3GHG 2.9Å Yes No
3H32_E (4177796) Fibrinogen beta chain UNMATCHED, UNMATCHED, UNMATCHED 3H32 3.6Å Yes No
3H32_B (4177797) Fibrinogen beta chain UNMATCHED, UNMATCHED, UNMATCHED 3H32 3.6Å Yes No
3HUS_B (4011896) Fibrinogen beta chain UNMATCHED, UNMATCHED, UNMATCHED 3HUS 3.04Å Yes No
3HUS_E (4200508) Fibrinogen beta chain UNMATCHED, UNMATCHED, UNMATCHED 3HUS 3.04Å Yes No
Ligand-based Druggability Score: -0.8
Ligand-based Druggability Score Percentile: 71%
Ligand-based Druggability Help: Help




		
Number of proteins in the network : 13346


FGB is involved in 16 interactions in the network.


Druggability
Overall Druggability Percentile: 89.47
Druggability for Cancer Therapeutics: 74.75
Druggability for Other Therapeutics: 98.07
Cancer-Associated
Cancer-associated percentile : 73.49
Network Articulation Point
Is FGB critical for communication in the network?


Detailed Graph Legend:Help