Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

FGB (P02675) - Overview - Molecular Target Synopsis

Protein


FGB, Fibrinogen beta chain
UniProt P02675

Also Known as FIBB_HUMAN, FGB

Cleaved by the protease thrombin to yield monomers which, together with fibrinogen alpha (FGA) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. Fibrin has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However subsequent studies have shown that it is not absolutely required for thrombus formation in vivo. Enhances expression of SELP in activated platelets. Maternal fibrinogen is essential for successful pregnancy. Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage. May also facilitate the antibacterial immune response via both innate and T-cell mediated pathways. Heterohexamer; disulfide linked. Contains 2 sets of 3 non-identical chains (alpha, beta and gamma). The 2 heterotrimers are in head to head conformation with the N-termini in a small central domain.

6BIJ
11 RESIDUE FRAGMENT OF
CITRULLINATED FIBRINOGEN 72,74CIT69-81
IN THE STRUCTURE OF
HLA-DRB1 IN COMPLEX WITH CITRULLINATED FIBRINOGEN PEPTIDE
RCSB/PDB
Inspect Structure
See all 3D Structures for FGB

Isoforms / Transcripts (Protein Coding)


Drugs


FGB is targeted by Approved Drug Fibrinolysin, Human. (see details)
Fibrinolysin, Human

Sub-cellular localization


Gene Copy Number Variation


In COSMIC - Cell Lines Project FGB has gain in 1 cell-lines, loss in 4 cell-lines and no signal in 1000 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: CAKI_1, EKVX, MCF7

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: HuH-7, NCI-H1944, HCC515

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: A549, SK-N-SH, NHLF

(see details)

3D Structures


For FGB there are:
35 structures (86 chains) solved
30 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


FGB has been screened with compounds ( bioactivities). (see details)