Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

FGA (P02671) - Overview - Molecular Target Synopsis

Protein


FGA, Fibrinogen alpha chain
UniProt P02671

Also Known as FIBA_HUMAN, FGA

Cleaved by the protease thrombin to yield monomers which, together with fibrinogen beta (FGB) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. Fibrin has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However, subsequent studies have shown that it is not absolutely required for thrombus formation in vivo. Enhances expression of SELP in activated platelets via an ITGB3-dependent pathway. Maternal fibrinogen is essential for successful pregnancy. Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage. May also facilitate the immune response via both innate and T-cell mediated pathways. Heterohexamer; disulfide linked. Contains 2 sets of 3 non-identical chains (alpha, beta and gamma). The 2 heterotrimers are in head to head conformation with the N-termini in a small central domain.

5CFA
10 RESIDUE FRAGMENT OF
PEPTIDE FROM FIBRINOGEN ALPHA CHAIN
IN THE STRUCTURE OF
CRYSTAL STRUCTURES OF BBP FROM STAPHYLOCOCCUS AUREUS WITH PEPTIDE LIGAND
RCSB/PDB
Inspect Structure
See all 3D Structures for FGA

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
866ENSG00000171560ENST00000302053ENSP00000306361P02671-1
644ENSG00000171560ENST00000403106ENSP00000385981P02671-2

Drugs


FGA is targeted by Approved Drug Fibrinolysin, Human. (see details)
Fibrinolysin, Human

Sub-cellular localization


Gene Copy Number Variation


In COSMIC - Cell Lines Project FGA has gain in 1 cell-lines, loss in 4 cell-lines and no signal in 1000 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: EKVX, CAKI_1, MCF7

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: JHH-7, Hep G2, NCI-H1944

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: HepG2, A549, SK-N-SH

(see details)

3D Structures


For FGA there are:
39 structures (91 chains) solved
2 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


FGA has been screened with compounds ( bioactivities). (see details)