Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

COL1A1 (P02452) - Overview - Molecular Target Synopsis

Protein


COL1A1, Collagen alpha-1(I) chain
UniProt P02452

Also Known as CO1A1_HUMAN, COL1A1

Type I collagen is a member of group I collagen (fibrillar forming collagen). Trimers of one alpha 2(I) and two alpha 1(I) chains. Interacts with MRC2 (By similarity). Interacts with TRAM2 (PubMed:14749390). Interacts with MFAP4 in a Ca (2+)-dependent manner.

5OU8
10 RESIDUE FRAGMENT OF
(GPO)5
IN THE STRUCTURE OF
CRYSTAL STRUCTURE OF GLYCOPROTEIN VI IN COMPLEX WITH COLLAGEN-PEPTIDE (GPO)5
RCSB/PDB
Inspect Structure
See all 3D Structures for COL1A1

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
1464ENSG00000108821ENST00000225964ENSP00000225964P02452-1
154ENSG00000108821ENST00000507689ENSP00000460459

Sub-cellular localization


UniProt: COL1A1 is active in the following subcellular-locations: extracellular matrix, extracellular space, secreted.
GO terms: COL1A1 is active in the following subcellular-locations: collagen type I trimer, collagen-containing extracellular matrix, cytoplasm, endoplasmic reticulum lumen, extracellular matrix, extracellular region, extracellular space, Golgi apparatus, secretory granule.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project COL1A1 has gain in 5 cell-lines, loss in 0 cell-lines and no signal in 1000 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: HS578T, SF_539, SNB_75

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: NCI-H2373, Hs 839.T, LXF-289

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, BJ, NHLF

(see details)

3D Structures


For COL1A1 there are:
11 structures (36 chains) solved
5 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


COL1A1 has been screened with compounds ( bioactivities). (see details)