Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

HLA-A (P01892) - Overview - Molecular Target Synopsis

Protein


HLA-A, HLA class I histocompatibility antigen, A-2 alpha chain
UniProt P01892

Also Known as 1A02_HUMAN, HLA-A, HLAA

Involved in the presentation of foreign antigens to the immune system. Dimer of alpha chain and a beta chain (beta-2-microglobulin).

6DKP
THE COMPLEX AMONG DMF5(ALPHA-D26Y, ALPHA-Y50A,BETA-L98W) TCR, HUMAN CLASS I MHC HLA-A2 AND MART-1(26-35)(A27L) PEPTIDE
RCSB/PDB
Inspect Structure
See all 3D Structures for HLA-A

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
365P01892-1

Sub-cellular localization


Gene Copy Number Variation


In COSMIC - Cell Lines Project HLA-A has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: SK_OV_3, MALME_3M, SNB_75

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: G22, HCC461, LCLC-103H

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HeLa-S3

(see details)

3D Structures


For HLA-A there are:
267 structures (434 chains) solved
15 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


HLA-A has been screened with compounds ( bioactivities). (see details)