Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

B2m (P01887) - Overview - Molecular Target Synopsis

Protein


B2m, Beta-2-microglobulin
UniProt P01887

Also Known as B2MG_MOUSE, B2m

Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. Heterodimer of an alpha chain and a beta chain. Beta-2-microglobulin is the beta-chain of major histocompatibility complex class I molecules.

6G9R
MURINE CLASS I MAJOR HISTOCOMPATIBILITY COMPLEX H-2 DB IN COMPLEX WITH SELF-ANTIGEN DERIVED FROM DOPAMINE MONOOXYGENASE.
RCSB/PDB
Inspect Structure
See all 3D Structures for B2m

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
119P01887-1

Sub-cellular localization


UniProt: B2m is active in the following subcellular-locations: secreted.
GO terms: B2m is active in the following subcellular-locations: cytosol, external side of plasma membrane, extracellular space, Golgi apparatus, HFE-transferrin receptor complex, MHC class I protein complex, phagocytic vesicle membrane, plasma membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project B2m has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For B2m there are:
281 structures (456 chains) solved
3 are solved in complex with at least one small molecule ligand
1 are solved with an approved drug

B2m is solved in complex with the approved drug(s):

TAR/TARTARIC ACID (5FKP_B).

(see details)
Molecular Target 3D Synopsis