Molecular Target Synopsis
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Ighm (P01872) - Overview - Molecular Target Synopsis

Protein


Ighm, Immunoglobulin heavy constant mu
UniProt P01872

Also Known as IGHM_MOUSE, Ighm, Igh-6

IgM antibodies play an important role in primary defense mechanisms. They have been shown to be involved in early recognition of external invaders like bacteria and viruses, cellular waste and modified self, as well as in recognition and elimination of precancerous and cancerous lesions. Immunoglobulin (Ig) molecules consist of two chains, one heavy chain (which can be alpha, delta, epsilon, gamma or mu) and one light chain (which can be kappa or lambda) each consisting of a variable and a constant region. An IgM molecule contains thus a mu heavy chain combined with either a kappa or a lambda light chains.

4BA8
HIGH RESOLUTION NMR STRUCTURE OF THE C MU3 DOMAIN FROM IGM
RCSB/PDB
Inspect Structure
See all 3D Structures for Ighm

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
475P01872-2
454P01872-1

Sub-cellular localization


UniProt: Ighm is active in the following subcellular-locations: cell membrane, secreted.
GO terms: Ighm is active in the following subcellular-locations: B cell receptor complex, cell surface, cytosol, external side of plasma membrane, extracellular space, immunoglobulin complex, integral component of membrane, membrane, perinuclear region of cytoplasm, plasma membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project Ighm has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For Ighm there are:
3 structures (7 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis