Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

IGHG1 (P01857) - Overview - Molecular Target Synopsis

Protein


IGHG1, Immunoglobulin heavy constant gamma 1
UniProt P01857

Also Known as IGHG1_HUMAN, IGHG1

Constant region of immunoglobulin heavy chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268). Immunoglobulins are composed of two identical heavy chains and two identical light chains; disulfide-linked.

6DCV
CRYSTAL STRUCTURE OF HUMAN ANTI-TAU ANTIBODY CBTAU-27.1
RCSB/PDB
Inspect Structure
See all 3D Structures for IGHG1

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: IGHG1 is active in the following subcellular-locations: cell membrane, secreted.
GO terms: IGHG1 is active in the following subcellular-locations: blood microparticle, external side of plasma membrane, extracellular exosome, extracellular region, extracellular space, immunoglobulin complex.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project IGHG1 has gain in 11 cell-lines, loss in 19 cell-lines and no signal in 833 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: HS578T, HL_60, IGROV1

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: NU-DUL-1, SC-1, KMS-27

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: CD20-positive B cell, GM12878, SK-N-SH

(see details)

3D Structures


For IGHG1 there are:
156 structures (313 chains) solved
117 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


IGHG1 has been screened with compounds ( bioactivities). (see details)