Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

IGHE (P01854) - Overview - Molecular Target Synopsis

Protein


IGHE, Immunoglobulin heavy constant epsilon
UniProt P01854

Also Known as IGHE_HUMAN, IGHE

Constant region of immunoglobulin heavy chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268). Immunoglobulins are composed of two identical heavy chains and two identical light chains; disulfide-linked.

5NQW
IGE-FC IN COMPLEX WITH SINGLE DOMAIN ANTIBODY 026
RCSB/PDB
Inspect Structure
See all 3D Structures for IGHE

Isoforms / Transcripts (Protein Coding)


Drugs


IGHE is targeted by Approved Drug Omalizumab. (see details)
Omalizumab

Sub-cellular localization


UniProt: IGHE is active in the following subcellular-locations: cell membrane, secreted.
GO terms: IGHE is active in the following subcellular-locations: external side of plasma membrane, extracellular region, immunoglobulin complex.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project IGHE has gain in 5 cell-lines, loss in 2 cell-lines and no signal in 986 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are:

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: U266B1, Pfeiffer, KARPAS-1106P

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HSMM

(see details)

3D Structures


For IGHE there are:
23 structures (74 chains) solved
20 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


IGHE has been screened with 1 compounds (1 bioactivities). (see details)