TNF (P01375) - Overview - Molecular Target Synopsis
TNF, Tumor necrosis factor
Also Known as TNFA_HUMAN, TNF, TNFA, TNFSF2
Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation. Impairs regulatory T-cells (Treg) function in individuals with rheumatoid arthritis via FOXP3 dephosphorylation. Upregulates the expression of protein phosphatase 1 (PP1), which dephosphorylates the key 'Ser-418' residue of FOXP3, thereby inactivating FOXP3 and rendering Treg cells functionally defective (PubMed:23396208)., The TNF intracellular domain (ICD) form induces IL12 production in dendritic cells. Homotrimer. Interacts with SPPL2B.
|Protein Length||Ensembl Gene||Ensembl Transcript||Ensembl Protein||Uniprot Isoform|
MSTESMIRDV ELAEEALPKK TGGPQGSRRC LFLSLFSFLI VAGATTLFCL
LHFGVIGPQR EEFPRDLSLI SPLAQAVRSS SRTPSDKPVA HVVANPQAEG
QLQWLNRRAN ALLANGVELR DNQLVVPSEG LYLIYSQVLF KGQGCPSTHV
LLTHTISRIA VSYQTKVNLL SAIKSPCQRE TPEGAEAKPW YEPIYLGGVF
QLEKGDRLSA EINRPDYLDF AESGQVYFGI IAL
|TNF is targeted by Approved Drugs Etanercept, Null, Infliximab, Adalimumab, Null. (see details)|
UniProt: TNF is active in the following subcellular-locations: Cell membrane, Membrane, Secreted.
GO terms: TNF is active in the following subcellular-locations: cell surface, external side of plasma membrane, extracellular region, extracellular space, integral component of plasma membrane, membrane raft, phagocytic cup, plasma membrane, recycling endosome.
|Please click the link to see mutations reported in COSMIC - Cell Lines Project|
|Please click the link to see mutations reported in COSMIC|
|Please click the link to see mutations reported in Cancer Gene Census|
|Please click the link to see mutations reported in ICGC|