TNF, Tumor necrosis factor
Also Known as
TNFA_HUMAN, TNF, TNFA, TNFSF2
Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation., The TNF intracellular domain (ICD) form induces IL12 production in dendritic cells. Homotrimer. Interacts with SPPL2B.
Isoforms / Transcripts (Protein Coding)
MSTESMIRDV ELAEEALPKK TGGPQGSRRC LFLSLFSFLI VAGATTLFCL
LHFGVIGPQR EEFPRDLSLI SPLAQAVRSS SRTPSDKPVA HVVANPQAEG
QLQWLNRRAN ALLANGVELR DNQLVVPSEG LYLIYSQVLF KGQGCPSTHV
LLTHTISRIA VSYQTKVNLL SAIKSPCQRE TPEGAEAKPW YEPIYLGGVF
QLEKGDRLSA EINRPDYLDF AESGQVYFGI IAL
TNF is targeted by Approved Drugs Etanercept, Null, Infliximab, Adalimumab, Null. (see details)
UniProt: TNF is active in the following subcellular-locations: Cell membrane, Membrane, Secreted.
GO terms: TNF is active in the following subcellular-locations: cell surface, external side of plasma membrane, extracellular region, extracellular space, integral component of plasma membrane, membrane raft, phagocytic cup, plasma membrane, recycling endosome.
Mutations in Cancer
|Please click the link to see mutations reported in COSMIC - Cell Lines Project|
|Please click the link to see mutations reported in COSMIC|
|Please click the link to see mutations reported in Cancer Gene Census|
|Please click the link to see mutations reported in ICGC|
In the NCI - NCI 60 Reference panel, the highest expressing cell lines are: SR, CCRFCEM. (see details)
TNF was reported in the following RNAI studies:
AACR Journals - Results of primary druggable genome v2 (DG2) Achilles heel siRNA screen in KMS11 multiple myeloma cells, the highest RNAi cell lines are: KMS11. (see details)
Screening and Chemistry
TNF has been screened with 199 compounds (284 bioactivities), 26 compounds have bioactivities that show binding affinity of <= 500nM (27 bioactivities). (see details)