Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

INS (P01308) - Overview - Molecular Target Synopsis

Protein


INS, Insulin
UniProt P01308

Also Known as INS_HUMAN, INS

Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. Heterodimer of a B chain and an A chain linked by two disulfide bonds (PubMed:25423173).

6HN5
25 RESIDUE FRAGMENT OF
INSULIN
IN THE STRUCTURE OF
LEUCINE-ZIPPERED HUMAN INSULIN RECEPTOR ECTODOMAIN WITH SINGLE BOUND INSULIN - "UPPER" MEMBRANE-DISTAL PART
RCSB/PDB
Inspect Structure
See all 3D Structures for INS

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


Gene Copy Number Variation


In COSMIC - Cell Lines Project INS has gain in 0 cell-lines, loss in 2 cell-lines and no signal in 1002 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: MCF7, NCI_H460, SK_MEL_5

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: Hs 746T, NCI-H209, LN-18

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HSMM

(see details)

3D Structures


For INS there are:
267 structures (1274 chains) solved
103 are solved in complex with at least one small molecule ligand
53 are solved with an approved drug

INS is solved in complex with the approved drug(s):

IPH/PHENOL (1AI0_B, 1AI0_D, 1AI0_E, 1AI0_G, 1AI0_J, 1AI0_L, 1AIY_B, 1AIY_D, 1AIY_F, 1AIY_H, 1AIY_J, 1AIY_L, 1LPH_C, 1Q4V_C, 1QIY_A, 1QIY_C, 1QIY_E, 1QIY_G, 1QIY_I, 1QIY_K, 1RWE_C, 1W8P_A, 1W8P_C, 1W8P_E, 1W8P_G, 1W8P_I, 1W8P_K, 1XDA_A, 1XDA_C, 1XDA_E, 1XDA_G, 1XW7_A, 1XW7_C, 1ZEG_A, 1ZEG_B, 1ZEG_C, 1ZNJ_A, 1ZNJ_B, 1ZNJ_C, 1ZNJ_E, 1ZNJ_G, 1ZNJ_I, 1ZNJ_K, 2AIY_A, 2AIY_C, 2AIY_E, 2AIY_G, 2AIY_I, 2AIY_K, 2WS6_A, 2WS6_C, 2WS6_E, 2WS6_G, 2WS6_I, 2WS6_K, 2WS7_A, 2WS7_C, 2WS7_E, 2WS7_G, 2WS7_I, 2WS7_K, 3AIY_A, 3AIY_C, 3AIY_E, 3AIY_G, 3AIY_I, 3AIY_K, 3JSD_C, 3KQ6_C, 3P2X_C, 3P33_A, 3P33_C, 3P33_E, 3P33_G, 3ROV_A, 3ROV_C, 3ROV_E, 3ROV_G, 3ROV_I, 3ROV_K, 3V19_C, 3V1G_C, 3ZQR_A, 3ZQR_C, 3ZQR_E, 3ZQR_H, 3ZQR_I, 3ZQR_K, 3ZS2_A, 3ZS2_C, 3ZS2_E, 3ZS2_G, 3ZS2_I, 3ZS2_K, 4AIY_A, 4AIY_C, 4AIY_E, 4AIY_G, 4AIY_I, 4AIY_K, 4AJZ_D, 4AKJ_A, 4AKJ_C, 4P65_A, 4P65_C, 4P65_E, 4P65_G, 4P65_I, 4P65_K, 5AIY_A, 5AIY_C, 5AIY_E, 5AIY_G, 5AIY_I, 5AIY_K, 5BQQ_A, 5BQQ_C, 5BQQ_E, 5BQQ_G, 5BQQ_H, 5BQQ_I, 5BQQ_J, 5BQQ_K, 5EMS_A, 5EMS_C, 5EMS_E, 5EMS_G, 5EMS_I, 5EMS_K, 5HPU_A, 5HPU_C, 5HRQ_A, 5HRQ_C, 5HRQ_E, 5HRQ_G, 5HRQ_I, 5HRQ_K, 5UDP_A, 5UDP_C, 5UDP_E, 5UDP_G, 5UDP_I, 5UDP_K, 5UQA_A, 5UQA_C, 5UQA_E, 5UQA_G, 5UQA_I, 5UQA_K, 5URU_A, 5URU_C, 5URU_E, 5URU_G, 5USS_A, 5USS_C, 5UU3_A, 5UU3_C, 5UU3_E, 5UU3_G, 5UU3_I, 5UU3_K, 5UU3_M, 5UU3_Q, 5UU3_S, 5UU3_U, 5UU3_W, 5UU4_A, 5UU4_C, 6CK2_C),
RCO/RESORCINOL (1EVR_A, 1EVR_B, 1EVR_C, 1EVR_E, 1EVR_G, 1EVR_I, 1EVR_K, 1QIZ_A, 1QIZ_C, 1QIZ_E, 1QIZ_G, 1QIZ_I, 1QIZ_K, 2OLY_A, 2OLY_B, 2OLY_C, 2OLY_E, 2OLY_G, 2OLY_I, 2OLY_J, 2OLY_K, 2OLZ_A, 2OLZ_C, 2OLZ_E, 2OLZ_G, 2OLZ_I, 2OLZ_K, 2OM0_1, 2OM0_3, 2OM0_A, 2OM0_C, 2OM0_E, 2OM0_G, 2OM0_I, 2OM0_K, 2OM0_Q, 2OM0_S, 2OM0_U, 2OM0_X, 2OM0_a, 2OM0_c, 2OM0_e, 2OM0_g, 2OM0_i, 2OM0_k, 2OM1_1, 2OM1_3, 2OM1_A, 2OM1_C, 2OM1_E, 2OM1_G, 2OM1_I, 2OM1_K, 2OM1_Q, 2OM1_S, 2OM1_U, 2OM1_X, 2OM1_a, 2OM1_c, 2OM1_e, 2OM1_g, 2OM1_i, 2OM1_k, 2OMH_A, 2OMH_C, 2OMH_E, 2OMI_A, 2OMI_C, 2OMI_E, 2OMI_G, 2OMI_I, 2OMI_K, 2W44_A, 2W44_C, 2W44_E, 3ZU1_B, 3ZU1_D, 4AJX_B, 4AJX_D, 4AJX_E, 4AJX_G, 4AJX_J, 4AJX_L),
TYL/ACETAMINOPHEN (1TYL_C, 1TYM_C).

(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


INS has been screened with 13 compounds (13 bioactivities). (see details)