Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

PRL (P01236) - Overview - Molecular Target Synopsis

Protein


PRL, Prolactin
UniProt P01236

Also Known as PRL_HUMAN, PRL

Prolactin acts primarily on the mammary gland by promoting lactation. Interacts with PRLR.

3NPZ
PROLACTIN RECEPTOR (PRLR) COMPLEXED WITH THE NATURAL HORMONE (PRL)
RCSB/PDB
Inspect Structure
See all 3D Structures for PRL

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
227ENSG00000172179ENST00000306482ENSP00000302150P01236-1

Sub-cellular localization


UniProt: PRL is active in the following subcellular-locations: secreted.
GO terms: PRL is active in the following subcellular-locations: endosome lumen, extracellular region, extracellular space.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project PRL has gain in 6 cell-lines, loss in 0 cell-lines and no signal in 999 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: UACC_62, RPMI_8226, SK_MEL_5

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: TOV-112D, NCI-H146, QGP-1

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HSMM

(see details)

3D Structures


For PRL there are:
12 structures (12 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


PRL has been screened with compounds ( bioactivities). (see details)