Molecular Target Synopsis
Overview
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Ligand Efficiency Plot
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KRAS (P01116) - Pathways - Molecular Target Synopsis

Data acquired from 76 pathway associations found
Pathway Name Source
Activated NTRK2 signals through FRS2 and FRS3Reactome v61 (only 'Homo_sapiens.owl') 23-Jun-2017
Activated NTRK2 signals through RASReactome v61 (only 'Homo_sapiens.owl') 23-Jun-2017
Activated NTRK3 signals through RASReactome v61 (only 'Homo_sapiens.owl') 23-Jun-2017
Activation of RAS in B cellsReactome v61 (only 'Homo_sapiens.owl') 23-Jun-2017
CD209 (DC-SIGN) signalingReactome v61 (only 'Homo_sapiens.owl') 23-Jun-2017
Constitutive Signaling by EGFRvIIIReactome v61 (only 'Homo_sapiens.owl') 23-Jun-2017
Constitutive Signaling by Ligand-Responsive EGFR Cancer VariantsReactome v61 (only 'Homo_sapiens.owl') 23-Jun-2017
DAP12 signalingReactome v61 (only 'Homo_sapiens.owl') 23-Jun-2017
Downstream signal transductionReactome v61 (only 'Homo_sapiens.owl') 23-Jun-2017
EGFR Transactivation by GastrinReactome v61 (only 'Homo_sapiens.owl') 23-Jun-2017
Erythropoietin activates RASReactome v61 (only 'Homo_sapiens.owl') 23-Jun-2017
FCERI mediated MAPK activationReactome v61 (only 'Homo_sapiens.owl') 23-Jun-2017
FRS-mediated FGFR1 signalingReactome v61 (only 'Homo_sapiens.owl') 23-Jun-2017
FRS-mediated FGFR2 signalingReactome v61 (only 'Homo_sapiens.owl') 23-Jun-2017
FRS-mediated FGFR3 signalingReactome v61 (only 'Homo_sapiens.owl') 23-Jun-2017
FRS-mediated FGFR4 signalingReactome v61 (only 'Homo_sapiens.owl') 23-Jun-2017
GRB2 events in EGFR signalingReactome v61 (only 'Homo_sapiens.owl') 23-Jun-2017
GRB2 events in ERBB2 signalingReactome v61 (only 'Homo_sapiens.owl') 23-Jun-2017
Insulin receptor signalling cascadeReactome v61 (only 'Homo_sapiens.owl') 23-Jun-2017
MAP2K and MAPK activationReactome v61 (only 'Homo_sapiens.owl') 23-Jun-2017
MET activates RAS signalingReactome v61 (only 'Homo_sapiens.owl') 23-Jun-2017
NCAM signaling for neurite out-growthReactome v61 (only 'Homo_sapiens.owl') 23-Jun-2017
Negative regulation of MAPK pathwayReactome v61 (only 'Homo_sapiens.owl') 23-Jun-2017
p38MAPK eventsReactome v61 (only 'Homo_sapiens.owl') 23-Jun-2017
Paradoxical activation of RAF signaling by kinase inactive BRAFReactome v61 (only 'Homo_sapiens.owl') 23-Jun-2017
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinasesReactome v61 (only 'Homo_sapiens.owl') 23-Jun-2017
RAF activationReactome v61 (only 'Homo_sapiens.owl') 23-Jun-2017
RAF/MAP kinase cascadeReactome v61 (only 'Homo_sapiens.owl') 23-Jun-2017
Ras activation upon Ca2+ influx through NMDA receptorReactome v61 (only 'Homo_sapiens.owl') 23-Jun-2017
RAS signaling downstream of NF1 loss-of-function variantsReactome v61 (only 'Homo_sapiens.owl') 23-Jun-2017
Regulation of RAS by GAPsReactome v61 (only 'Homo_sapiens.owl') 23-Jun-2017
RUNX3 regulates p14-ARFReactome v61 (only 'Homo_sapiens.owl') 23-Jun-2017
SHC-mediated cascade:FGFR1Reactome v61 (only 'Homo_sapiens.owl') 23-Jun-2017
SHC-mediated cascade:FGFR2Reactome v61 (only 'Homo_sapiens.owl') 23-Jun-2017
SHC-mediated cascade:FGFR3Reactome v61 (only 'Homo_sapiens.owl') 23-Jun-2017
SHC-mediated cascade:FGFR4Reactome v61 (only 'Homo_sapiens.owl') 23-Jun-2017
SHC-related events triggered by IGF1RReactome v61 (only 'Homo_sapiens.owl') 23-Jun-2017
SHC1 events in EGFR signalingReactome v61 (only 'Homo_sapiens.owl') 23-Jun-2017
SHC1 events in ERBB2 signalingReactome v61 (only 'Homo_sapiens.owl') 23-Jun-2017
SHC1 events in ERBB4 signalingReactome v61 (only 'Homo_sapiens.owl') 23-Jun-2017
Signaling by BRAF and RAF fusionsReactome v61 (only 'Homo_sapiens.owl') 23-Jun-2017
Signaling by FGFR1 in diseaseReactome v61 (only 'Homo_sapiens.owl') 23-Jun-2017
Signaling by FGFR2 in diseaseReactome v61 (only 'Homo_sapiens.owl') 23-Jun-2017
Signaling by FGFR3 fusions in cancerReactome v61 (only 'Homo_sapiens.owl') 23-Jun-2017
Signaling by FGFR3 point mutants in cancerReactome v61 (only 'Homo_sapiens.owl') 23-Jun-2017
Signaling by FGFR4 in diseaseReactome v61 (only 'Homo_sapiens.owl') 23-Jun-2017
Signaling by high-kinase activity BRAF mutantsReactome v61 (only 'Homo_sapiens.owl') 23-Jun-2017
Signaling by moderate kinase activity BRAF mutantsReactome v61 (only 'Homo_sapiens.owl') 23-Jun-2017
Signaling by RAS mutantsReactome v61 (only 'Homo_sapiens.owl') 23-Jun-2017
Signaling by SCF-KITReactome v61 (only 'Homo_sapiens.owl') 23-Jun-2017
Signalling to RASReactome v61 (only 'Homo_sapiens.owl') 23-Jun-2017
SOS-mediated signallingReactome v61 (only 'Homo_sapiens.owl') 23-Jun-2017
Tie2 SignalingReactome v61 (only 'Homo_sapiens.owl') 23-Jun-2017
VEGFR2 mediated cell proliferationReactome v61 (only 'Homo_sapiens.owl') 23-Jun-2017
EGF signaling pathway ( EGF signaling pathway Diagram )INOH 4.0 (signal transduction and metabolic data), 22-MAR-2011
EGFR1NetPath 12/2011
FGF signaling pathway ( FGF signaling pathway )INOH 4.0 (signal transduction and metabolic data), 22-MAR-2011
FGF8 signaling pathway(Mouse) ( FGF signaling pathway )INOH 4.0 (signal transduction and metabolic data), 22-MAR-2011
FGF8 signaling pathway(Xenopus) ( FGF signaling pathway )INOH 4.0 (signal transduction and metabolic data), 22-MAR-2011
HGF signaling pathway ( HGF signaling pathway )INOH 4.0 (signal transduction and metabolic data), 22-MAR-2011
IGF1 signaling pathway ( IGF1 signaling pathway )INOH 4.0 (signal transduction and metabolic data), 22-MAR-2011
Inflammation mediated by chemokine and cytokine signaling pathwayPANTHER Pathways 3.4.1 on 04-Jul-2016 (auto-converted to human-only model)
Insulin receptor signaling ( Insulin receptor signaling )INOH 4.0 (signal transduction and metabolic data), 22-MAR-2011
Insulin receptor signaling (Mammal) ( Insulin receptor signaling (Mammal) )INOH 4.0 (signal transduction and metabolic data), 22-MAR-2011
Integrin signaling pathway ( Integrin signaling pathway )INOH 4.0 (signal transduction and metabolic data), 22-MAR-2011
NGF signaling pathway ( NGF signaling pathway )INOH 4.0 (signal transduction and metabolic data), 22-MAR-2011
p53 pathway feedback loops 2PANTHER Pathways 3.4.1 on 04-Jul-2016 (auto-converted to human-only model)
PDGF signaling pathway ( PDGF signaling pathway )INOH 4.0 (signal transduction and metabolic data), 22-MAR-2011
PDGF signaling pathway (Mammal) ( PDGF signaling pathway )INOH 4.0 (signal transduction and metabolic data), 22-MAR-2011
Raf activation signaling (through Grb2 and Sos) ( B cell receptor signaling )INOH 4.0 (signal transduction and metabolic data), 22-MAR-2011
Raf activation signaling (through Grb2 and Sos) ( CD4 T cell receptor signaling (ERK cascade) )INOH 4.0 (signal transduction and metabolic data), 22-MAR-2011
Raf activation signaling (through Grb2 and Sos) ( CD4 T cell receptor signaling )INOH 4.0 (signal transduction and metabolic data), 22-MAR-2011
Raf activation signaling (through Grb2 and Sos) ( JAK-STAT pathway and regulation pathway Diagram )INOH 4.0 (signal transduction and metabolic data), 22-MAR-2011
Raf activation signaling (through RasGRP) ( CD4 T cell receptor signaling (ERK cascade) )INOH 4.0 (signal transduction and metabolic data), 22-MAR-2011
Raf activation signaling (through RasGRP) ( CD4 T cell receptor signaling )INOH 4.0 (signal transduction and metabolic data), 22-MAR-2011
Ras PathwayPANTHER Pathways 3.4.1 on 04-Jul-2016 (auto-converted to human-only model)