Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

NRAS (P01111) - Overview - Molecular Target Synopsis

Protein


NRAS, GTPase NRas
UniProt P01111

Also Known as RASN_HUMAN, NRAS, HRAS1

Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. Interacts (active GTP-bound form preferentially) with RGS14 (By similarity). Interacts (active GTP-bound form) with RASSF7.

5UHV
WILD-TYPE NRAS BOUND TO GPPNHP
RCSB/PDB
Inspect Structure
See all 3D Structures for NRAS

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
189ENSG00000213281ENST00000369535ENSP00000358548Q2MJK3-1, P01111-1

Sub-cellular localization


UniProt: NRAS is active in the following subcellular-locations: cell membrane, golgi apparatus membrane.
GO terms: NRAS is active in the following subcellular-locations: extracellular exosome, Golgi apparatus, Golgi membrane, membrane, plasma membrane, tertiary granule membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project NRAS has gain in 8 cell-lines, loss in 3 cell-lines and no signal in 994 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: MCF7, HS578T, MDA_MB_231

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: NCI-H2170, OVCAR-8, G112

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: NHLF, MCF-7, HSMM

(see details)

3D Structures


For NRAS there are:
3 structures (3 chains) solved
2 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


NRAS has been screened with 1 compounds (1 bioactivities), 1 compounds have bioactivities that show binding affinity of <= 500nM (1 bioactivities). (see details)