Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

ilvH (P00894) - Druggability - Molecular Target Synopsis

Chain-based assessment (last updated 23/04/2019)
Domain-based assessment (last updated 30/07/2012)


Structural Druggability Help: Help

Chain-based assessment (last updated 23/04/2019)


Chains assessed2
Chains with at least one site assessed as druggable using the strict criteria0
Chains with at least one site assessed as druggable using the relaxed criteria2


		
PDB Chain Protein Name Druggable Relaxed Druggable Strict Details
2F1F_B Acetolactate synthase isozyme 3 small subunit Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.99 60.3 25.8 Yes No
2 empty 2.05 55 22.1 No No
3 bound 2.48 61 16.5 No No
4 empty 2.59 61 13 No No
5 empty 2.52 50.7 11.4 No No
6 empty 2.44 71.4 8.6 No No
7 empty 2.02 71 9.9 No No
8 empty 1.83 73.5 7.6 No No
9 empty 2.2 70.8 6.1 No No
10 empty 2.64 51.4 8 No No
2F1F_A Acetolactate synthase isozyme 3 small subunit Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.77 66.2 27.1 Yes No
2 empty 2.03 60.7 18.5 No No
3 bound 2.6 64.9 17.9 No No
4 empty 2.4 71.3 10.4 No No
5 empty 2.48 61.2 17.4 No No
6 empty 2.42 63.4 8.3 No No
7 empty 2.29 71.7 9.8 No No
8 empty 2.63 70 11.1 No No
9 empty 2.22 72.2 7.8 No No
10 empty 2.12 69.4 8.9 No No

Domain-based assessment (last updated 30/07/2012)


Domains assessed6
Domains assessed as druggable using the strict criteria0
Domains assessed as druggable using the relaxed criteria0

PDB (Domain) Protein Name Domain Resolution Ligands Druggable Relaxed Druggable Strict
2F1F_A (132760) Acetolactate synthase isozyme 3 small subunit Ferredoxin-like, ACT-like, IlvH-like 1.75Å No No
2F1F_A (132761) Acetolactate synthase isozyme 3 small subunit Ferredoxin-like, ACT-like, IlvH-like 1.75Å No No
2F1F_B (132762) Acetolactate synthase isozyme 3 small subunit Ferredoxin-like, ACT-like, IlvH-like 1.75Å No No
2F1F_A (4139250) Acetolactate synthase isozyme 3 small subunit (Phosphotyrosine protein) phosphatases II, (Phosphotyrosine protein) phosphatases II, Dual specificity phosphatase-like (Homo Multimer) 1.75Å No No
2F1F_B (4090061) Acetolactate synthase isozyme 3 small subunit (Phosphotyrosine protein) phosphatases II, (Phosphotyrosine protein) phosphatases II, Dual specificity phosphatase-like (Homo Multimer) 1.75Å No No
2F1F_A (4090061) Acetolactate synthase isozyme 3 small subunit (Phosphotyrosine protein) phosphatases II, (Phosphotyrosine protein) phosphatases II, Dual specificity phosphatase-like (Homo Multimer) 1.75Å No No
2F1F_B (4139250) Acetolactate synthase isozyme 3 small subunit (Phosphotyrosine protein) phosphatases II, (Phosphotyrosine protein) phosphatases II, Dual specificity phosphatase-like (Homo Multimer) 1.75Å No No
2F1F_B (132763) Acetolactate synthase isozyme 3 small subunit Ferredoxin-like, ACT-like, IlvH-like 1.75Å No No
Ligand-based Druggability Score:
Ligand-based Druggability Score Percentile: %
Ligand-based Druggability Help: Help




		
This protein has no network-based druggability score