Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

ALDOA (P00883) - Overview - Molecular Target Synopsis

Protein


ALDOA, Fructose-bisphosphate aldolase A
Enzyme Classification 4.1.2.13
UniProt P00883

Also Known as ALDOA_RABIT, ALDOA

Plays a key role in glycolysis and gluconeogenesis. In addition, may also function as scaffolding protein. Homotetramer. Interacts with SNX9 and WAS. Interacts with FBP2; the interaction blocks FBP2 inhibition by physiological concentrations of AMP and reduces inhibition by Ca(2+).

6MWQ
SINGLE PARTICLE CRYOEM STRUCTURE OF A DARPIN-ALDOLASE PLATFORM IN COMPLEX WITH GFP
RCSB/PDB
Inspect Structure
See all 3D Structures for ALDOA

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
364P00883-1

Sub-cellular localization


UniProt: ALDOA is active in the following subcellular-locations: cytoplasm, i band, m line, myofibril, sarcomere.
GO terms: ALDOA is active in the following subcellular-locations: I band, M band.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project ALDOA has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For ALDOA there are:
32 structures (125 chains) solved
16 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


ALDOA has been screened with 29 compounds (34 bioactivities). (see details)