Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

npr (P00800) - Overview - Molecular Target Synopsis

Protein


npr, Thermolysin
Enzyme Classification 3.4.24.27
UniProt P00800

Also Known as THER_BACTH, npr

Extracellular zinc metalloprotease.

6QF2
X-RAY STRUCTURE OF THERMOLYSIN CRYSTALLIZED ON A SILICON CHIP
RCSB/PDB
Inspect Structure
See all 3D Structures for npr

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
548P00800-1

Sub-cellular localization


UniProt: npr is active in the following subcellular-locations: secreted.
GO terms: npr is active in the following subcellular-locations: extracellular region.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project npr has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For npr there are:
186 structures (188 chains) solved
140 are solved in complex with at least one small molecule ligand
5 are solved with an approved drug

npr is solved in complex with the approved drug(s):

BET/BETAINE (3T2J_E),
TRP/TRYPTOPHAN (2WI0_A, 3TMN_E),
TYR/TYROSINE (2WHZ_A),
IPH/PHENOL (1FJW_A).

(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


npr has been screened with 284 compounds (423 bioactivities), 49 compounds have bioactivities that show binding affinity of <= 500nM (63 bioactivities). (see details)