Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

CELA1 (P00772) - Overview - Molecular Target Synopsis

Protein


CELA1, Chymotrypsin-like elastase family member 1
Enzyme Classification 3.4.21.36
UniProt P00772

Also Known as CELA1_PIG, CELA1, ELA1

Acts upon elastin.

4YM9
CRYSTAL STRUCTURE OF PORCINE PANCREATIC ELASTASE (PPE) IN COMPLEX WITH THE NOVEL INHIBITOR JM102
RCSB/PDB
Inspect Structure
See all 3D Structures for CELA1

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
266P00772-1

Sub-cellular localization


UniProt: CELA1 is active in the following subcellular-locations: secreted.
GO terms: CELA1 is active in the following subcellular-locations: extracellular space.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project CELA1 has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For CELA1 there are:
117 structures (119 chains) solved
41 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


CELA1 has been screened with 405 compounds (472 bioactivities), 22 compounds have bioactivities that show binding affinity of <= 500nM (22 bioactivities). (see details)