Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

(P00760) - Overview - Molecular Target Synopsis

Protein


, Cationic trypsin
Enzyme Classification 3.4.21.4
UniProt P00760

Also Known as TRY1_BOVIN


6E5M
CRYSTALLOGRAPHIC STRUCTURE OF THE CYCLIC NONAPEPTIDE DERIVED FROM THE BTCI INHIBITOR BOUND TO BETA-TRYPSIN IN SPACE GROUP P 32 2 1
RCSB/PDB
Inspect Structure
See all 3D Structures for

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
246P00760-1

Sub-cellular localization


UniProt: is active in the following subcellular-locations: extracellular space, secreted.
GO terms: is active in the following subcellular-locations: extracellular space, serine protease inhibitor complex.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For there are:
478 structures (532 chains) solved
365 are solved in complex with at least one small molecule ligand
5 are solved with an approved drug

is solved in complex with the approved drug(s):

PNT/PENTAMIDINE (3GY3_A),
NCA/NIACINAMIDE (2OTV_A),
IPH/PHENOL (2J9N_A),
HSM/HISTAMINE (3RXH_A),
BET/BETAINE (3T27_A).

(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


has been screened with 1284 compounds (1535 bioactivities), 388 compounds have bioactivities that show binding affinity of <= 500nM (462 bioactivities). (see details)