Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

F2 (P00735) - Overview - Molecular Target Synopsis

Protein


F2, Prothrombin
Enzyme Classification 3.4.21.5
UniProt P00735

Also Known as THRB_BOVIN, F2

Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing. Heterodimer (named alpha-thrombin) of a light and a heavy chain; disulfide-linked. Forms a heterodimer with SERPINA5.

3PMB
29 RESIDUE FRAGMENT OF
THROMBIN LIGHT CHAIN
IN THE STRUCTURE OF
2.9 ANGSTROM CRYSTAL STRUCTURE OF BOVINE THROMBIN IN TETRAGONAL SPACEGROUP
RCSB/PDB
Inspect Structure
See all 3D Structures for F2

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
625P00735-1

Sub-cellular localization


UniProt: F2 is active in the following subcellular-locations: extracellular space, secreted.
GO terms: F2 is active in the following subcellular-locations: external side of plasma membrane, extracellular space.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project F2 has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For F2 there are:
28 structures (88 chains) solved
15 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


F2 has been screened with 1579 compounds (1662 bioactivities), 312 compounds have bioactivities that show binding affinity of <= 500nM (334 bioactivities). (see details)