Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

lacZ (P00722) - Overview - Molecular Target Synopsis

Protein


lacZ, Beta-galactosidase
Enzyme Classification 3.2.1.23
UniProt P00722

Also Known as BGAL_ECOLI, lacZ

Homotetramer.

6DRV
BETA-GALACTOSIDASE
RCSB/PDB
Inspect Structure
See all 3D Structures for lacZ

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
1024P00722-1

Sub-cellular localization


GO terms: lacZ is active in the following subcellular-locations: beta-galactosidase complex.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project lacZ has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For lacZ there are:
56 structures (224 chains) solved
37 are solved in complex with at least one small molecule ligand
1 are solved with an approved drug

lacZ is solved in complex with the approved drug(s):

TAR/TARTARIC ACID (1JZ8_B).

(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


lacZ has been screened with 89 compounds (89 bioactivities), 2 compounds have bioactivities that show binding affinity of <= 500nM (2 bioactivities). (see details)