Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

E (P00720) - Overview - Molecular Target Synopsis

Protein


E, Endolysin
Enzyme Classification 3.2.1.17
UniProt P00720

Also Known as ENLYS_BPT4, E

Endolysin with lysozyme activity that degrades host peptidoglycans and participates with the holin and spanin proteins in the sequential events which lead to the programmed host cell lysis releasing the mature viral particles. Once the holin has permeabilized the host cell membrane, the endolysin can reach the periplasm and break down the peptidoglycan layer.

6M9T
CRYSTAL STRUCTURE OF EP3 RECEPTOR BOUND TO MISOPROSTOL-FA
RCSB/PDB
Inspect Structure
See all 3D Structures for E

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
164P00720-1

Sub-cellular localization


UniProt: E is active in the following subcellular-locations: host cytoplasm.
GO terms: E is active in the following subcellular-locations: host cell cytoplasm.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project E has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For E there are:
695 structures (829 chains) solved
327 are solved in complex with at least one small molecule ligand
26 are solved with an approved drug

E is solved in complex with the approved drug(s):

CLR/CHOLESTEROL (2RH1_A, 3D4S_A, 3NY8_A, 3NY9_A, 3NYA_A, 3PDS_A, 4DKL_A, 5D5A_A, 5D5B_A, 5D6L_A, 5JQH_A, 5JQH_B, 5X7D_A, 5X93_A),
CCS/CARBOCYSTEINE (3RUN_A),
K86/BOSENTAN (5XPR_A),
IPH/PHENOL (1LI2_A, 3GUO_A, 3GUO_B, 4I7L_A, 4I7L_B),
0HK/TIOTROPIUM (4DAJ_A, 4DAJ_B, 4DAJ_C, 4DAJ_D, 4U14_A, 5CXV_A, 5DSG_A, 5DSG_B),
TIM/TIMOLOL (3D4S_A),
BGC/DEXTROSE (3UON_A),
VPX/VORAPAXAR (3VW7_A),
268/PHENOXYETHANOL (2RBR_A),
8NU/RISPERIDONE (6CM4_A).

(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


E has been screened with 20 compounds (21 bioactivities). (see details)