Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

LYZ (P00698) - Overview - Molecular Target Synopsis

Protein


LYZ, Lysozyme C
Enzyme Classification 3.2.1.17
UniProt P00698

Also Known as LYSC_CHICK, LYZ

Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents. Has bacteriolytic activity against M.luteus. Monomer.

6MUZ
LYSOZYME, ROOM TEMPERATURE STRUCTURE SOLVED BY SERIAL 3 DEGREE OSCILLATION CRYSTALLOGRAPHY
RCSB/PDB
Inspect Structure
See all 3D Structures for LYZ

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
147P00698-1

Sub-cellular localization


UniProt: LYZ is active in the following subcellular-locations: secreted.
GO terms: LYZ is active in the following subcellular-locations: cytoplasm, endoplasmic reticulum, extracellular space.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project LYZ has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For LYZ there are:
795 structures (912 chains) solved
151 are solved in complex with at least one small molecule ligand
6 are solved with an approved drug

LYZ is solved in complex with the approved drug(s):

G2F/FLUDEOXYGLUCOSE (1H6M_A),
SUC/SUCROSE (1JJ0_A, 3SP3_A, 3T6U_A),
TAR/TARTARIC ACID (2HUB_A),
010/BENZYL ALCOHOL (4II8_A).

(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


LYZ has been screened with 16 compounds (95 bioactivities). (see details)