Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

SRN (P00669) - Overview - Molecular Target Synopsis

Protein


SRN, Seminal ribonuclease
Enzyme Classification 4.6.1.18
UniProt P00669

Also Known as RNS_BOVIN, SRN

This enzyme hydrolyzes both single- and double-stranded RNA. Homodimer; disulfide-linked.

4N4C
CRYSTAL STRUCTURE OF THE C-TERMINAL SWAPPED DIMER OF A BOVINE SEMINAL RIBONUCLEASE MUTANT
RCSB/PDB
Inspect Structure
See all 3D Structures for SRN

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
150P00669-1

Sub-cellular localization


UniProt: SRN is active in the following subcellular-locations: secreted.
GO terms: SRN is active in the following subcellular-locations: extracellular region.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project SRN has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For SRN there are:
22 structures (42 chains) solved
13 are solved in complex with at least one small molecule ligand
1 are solved with an approved drug

SRN is solved in complex with the approved drug(s):

ADN/ADENOSINE (1N3Z_A).

(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


SRN has been screened with 5 compounds (5 bioactivities). (see details)