Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
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Chemistry
Ligand Efficiency Plot
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Gene Expression
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nuc (P00644) - Overview - Molecular Target Synopsis

Protein


nuc, Thermonuclease
Enzyme Classification 3.1.31.1
UniProt P00644

Also Known as NUC_STAAU, nuc

Enzyme that catalyzes the hydrolysis of both DNA and RNA at the 5' position of the phosphodiester bond.

6EEG
CRYSTAL STRUCTURE OF STAPHYLCOCCAL NUCLEASE VARIANT DELTA+PHS T62E AT CRYOGENIC TEMPERATURE
RCSB/PDB
Inspect Structure
See all 3D Structures for nuc

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
231P00644-1

Sub-cellular localization


UniProt: nuc is active in the following subcellular-locations: membrane, secreted.
GO terms: nuc is active in the following subcellular-locations: extracellular region, membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project nuc has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For nuc there are:
281 structures (297 chains) solved
188 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis