Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

FBP1 (P00636) - Overview - Molecular Target Synopsis

Protein


FBP1, Fructose-1,6-bisphosphatase 1
Enzyme Classification 3.1.3.11
UniProt P00636

Also Known as F16P1_PIG, FBP1, FBP

Catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate in the presence of divalent cations, acting as a rate-limiting enzyme in gluconeogenesis. Plays a role in regulating glucose sensing and insulin secretion of pancreatic beta-cells. Appears to modulate glycerol gluconeogenesis in liver. Important regulator of appetite and adiposity; increased expression of the protein in liver after nutrient excess increases circulating satiety hormones and reduces appetite-stimulating neuropeptides and thus seems to provide a feedback mechanism to limit weight gain. Homotetramer.

4H45
PRODUCT COMPLEXES OF PORCINE LIVER FRUCTOSE-1,6-BISPHOSPHATASE WITH MUTATION E192Q
RCSB/PDB
Inspect Structure
See all 3D Structures for FBP1

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
338P00636-1

Sub-cellular localization


GO terms: FBP1 is active in the following subcellular-locations: cytoplasm, cytosol, nucleus.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project FBP1 has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For FBP1 there are:
67 structures (110 chains) solved
65 are solved in complex with at least one small molecule ligand
30 are solved with an approved drug

FBP1 is solved in complex with the approved drug(s):

AMP/ADENOSINE PHOSPHATE (1EYJ_A, 1EYJ_B, 1EYK_A, 1EYK_B, 1FBP_A, 1FBP_B, 1FJ9_A, 1FJ9_B, 1FPD_A, 1FPD_B, 1FPE_A, 1FPE_B, 1FPF_A, 1FPF_B, 1FPG_A, 1FPG_B, 1FPI_A, 1FPI_B, 1FPJ_A, 1FPJ_B, 1FPL_A, 1FPL_B, 1FRP_A, 1FRP_B, 1FSA_A, 1FSA_B, 1KZ8_A, 1KZ8_F, 1NV7_A, 1NV7_B, 1RDY_A, 1RDY_B, 1RDZ_A, 1RDZ_B, 1YYZ_A, 1YZ0_A, 1YZ0_B, 2F3D_A, 4FBP_A, 4FBP_B, 4FBP_C, 4FBP_D, 4GBV_A, 4GBW_A, 4GWS_A, 4GWS_B, 4GWY_A, 4GWZ_A, 4GWZ_B, 4GX4_A, 4GX4_B, 4GX6_A, 4GX6_B, 4H46_A, 4KXP_A, 4KXP_B).

(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


FBP1 has been screened with 46 compounds (50 bioactivities), 1 compounds have bioactivities that show binding affinity of <= 500nM (1 bioactivities). (see details)