Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

PLA2G1B (P00593) - Overview - Molecular Target Synopsis

Protein


PLA2G1B, Phospholipase A2
Enzyme Classification 3.1.1.4
UniProt P00593

Also Known as PA21B_BOVIN, PLA2G1B

PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides, this releases glycerophospholipids and arachidonic acid that serve as the precursors of signal molecules. Monomer or homodimer. The inactive pro-form is a homotrimer.

2ZP5
CARBOXYLIC ESTER HYDROLASE, SINGLE MUTANT D49K OF BOVINE PANCREATIC PLA2 ENZYME
RCSB/PDB
Inspect Structure
See all 3D Structures for PLA2G1B

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
145P00593-1

Sub-cellular localization


UniProt: PLA2G1B is active in the following subcellular-locations: secreted.
GO terms: PLA2G1B is active in the following subcellular-locations: cell surface, cytosol, extracellular space.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project PLA2G1B has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

RNA Interference


PLA2G1B was reported in the following RNAI studies:

Cell - Large Scale Profiling of Kinase Dependencies in Cancer Cell Lines, the highest RNAi cell lines are: . (see details)

3D Structures


For PLA2G1B there are:
32 structures (33 chains) solved
5 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


PLA2G1B has been screened with 3 compounds (3 bioactivities). (see details)