Molecular Target Synopsis
Domains and Structures
Drugs and Clinical Candidates
Ligand Efficiency Plot
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
Germline Genetics

MOS (P00540) - Overview - Molecular Target Synopsis


MOS, Proto-oncogene serine/threonine-protein kinase mos
Enzyme Classification
UniProt P00540

Also Known as MOS_HUMAN, MOS

Isoforms / Transcripts (Protein Coding)

Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform

Sub-cellular localization

GO terms: MOS is active in the following subcellular-locations: cytoplasm, cytosol.

GO terms

Gene Copy Number Variation

In COSMIC - Cell Lines Project MOS has gain in 7 cell-lines, loss in 4 cell-lines and no signal in 994 cell-lines. (see details)

Gene Expression

In NCI60, the highest expressing cell lines are: NCI_H522, LOXIMVI, MOLT_4

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: Hs 746T, NCI-H209, LN-18

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HSMM

(see details)

RNA Interference

MOS was reported in the following RNAI studies:

Cell - Large Scale Profiling of Kinase Dependencies in Cancer Cell Lines, the highest RNAi cell lines are: MDAMB436, KPD. (see details)

Screening and Chemistry

MOS has been screened with 2 compounds (2 bioactivities). (see details)