Molecular Target Synopsis
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PRKACA (P00517) - Druggability - Molecular Target Synopsis

Chain-based assessment (last updated 08/10/2019)
Domain-based assessment (last updated 30/07/2012)


Structural Druggability Help: Help

Chain-based assessment (last updated 08/10/2019)


Chains assessed101
Chains with at least one site assessed as druggable using the strict criteria96
Chains with at least one site assessed as druggable using the relaxed criteria101


		
PDB Chain Protein Name Druggable Relaxed Druggable Strict Details
2JDT_A cAMP-dependent protein kinase catalytic subunit alpha Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2 73.7 34.6 Yes Yes
2 empty 2.02 65 30.9 No No
3 empty 2.76 73.5 17.3 No No
4 empty 2.2 71.2 19.6 No No
5 empty 2.14 69 18.9 No No
6 empty 2.28 68.8 17.4 No No
7 empty 2.08 65.4 19.1 No No
8 empty 1.82 61.2 14.7 No No
9 empty 2.38 62.4 20.7 No No
10 empty 1.85 70.2 11.7 No No
1XH5_A cAMP-dependent protein kinase catalytic subunit alpha Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.92 74.7 35.2 Yes Yes
2 empty 2 68 26.6 No No
3 empty 2.15 69.9 23.8 No No
4 bound 2.58 70.5 23.6 No No
5 empty 2.28 59 23.8 No No
6 empty 2.36 63.4 21.4 No No
7 bound 2.05 65.6 13.9 No No
8 empty 2.17 75.1 12.2 No No
9 empty 1.95 61.7 14.1 No No
10 empty 2.27 62.6 15.4 No No
1Q8T_A cAMP-dependent protein kinase catalytic subunit alpha Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.92 75.6 35.2 Yes Yes
2 empty 2.7 64.9 29.1 No No
3 empty 2.43 69.6 26.2 No No
4 empty 2.38 62.5 25.2 No No
5 empty 2.03 64.8 24.1 No No
6 empty 1.77 77.6 15.2 No No
7 empty 2.1 59.7 23 No No
8 empty 2.41 60.6 21.2 No No
9 empty 1.88 61.5 14.6 No No
10 empty 2.36 73.7 10.2 No No
3ZO2_A cAMP-dependent protein kinase catalytic subunit alpha Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.92 70.1 31.9 Yes Yes
2 bound 2.1 59.2 17 No No
3 empty 2.05 68.8 17.5 No No
4 empty 2.26 65.5 18.6 No No
5 empty 2.51 74.3 13.2 No No
6 bound 1.37 77.5 14.1 No No
7 empty 2.66 58.2 23.9 No No
8 empty 2.02 63.7 14 No No
9 empty 2.27 74.1 11.2 No No
10 empty 1.9 62.2 16.6 No No
4Z83_E cAMP-dependent protein kinase catalytic subunit alpha Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.87 75.9 35.2 Yes Yes
2 bound 1.89 67.1 29.2 No No
3 empty 2.14 69.4 28.3 No No
4 empty 2.38 75 17 No No
5 empty 2.04 64.1 18 No No
6 empty 2.08 64.2 16.8 No No
7 empty 2.34 61.9 19.2 No No
8 empty 1.91 65.9 13.4 No No
9 empty 2.23 60.3 17.6 No No
10 empty 1.91 63.2 13.5 No No
2F7Z_E cAMP-dependent protein kinase catalytic subunit alpha Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.82 71.9 36.5 Yes Yes
2 empty 1.96 69.2 28.6 No No
3 empty 2.22 66.9 36.2 No No
4 empty 2.48 74.6 19.6 No No
5 empty 2.4 65.7 19.4 No No
6 empty 2.12 63.6 21.5 No No
7 empty 2.07 63.4 20.6 No No
8 empty 2.08 63.3 15.3 No No
9 empty 2.51 64.9 21.3 No No
10 empty 2.1 83.3 11.3 No No
2UZV_A cAMP-dependent protein kinase catalytic subunit alpha Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.76 72.1 36.3 Yes Yes
2 empty 2.26 71 26 No No
3 empty 2.12 64.5 25.1 No No
4 bound 2.59 66.6 25 No No
5 empty 2.26 64.2 22.1 No No
6 empty 2.39 62.3 29 No No
7 empty 2.38 60.1 17.3 No No
8 empty 2.02 66.4 17.4 No No
9 empty 2.26 71.8 11.3 No No
10 empty 1.75 78.7 14.1 No No
1SZM_A cAMP-dependent protein kinase catalytic subunit alpha Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.92 74 34.5 Yes Yes
2 empty 2.01 65.1 31.9 No No
3 empty 2.25 65.3 27.4 No No
4 empty 2.42 61.5 22.2 No No
5 empty 1.65 68.7 14.9 No No
6 empty 2.32 64.4 21.5 No No
7 empty 2.24 68.3 14 No No
8 empty 2.05 65.4 15 No No
9 empty 2.11 74.8 11.9 No No
10 empty 1.86 66.6 12.2 No No
1Q62_A cAMP-dependent protein kinase catalytic subunit alpha Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.84 71.8 35.3 Yes Yes
2 empty 2.03 68.8 31.5 No No
3 empty 2.27 67.5 24.9 No No
4 empty 2.49 60.7 31.9 No No
5 empty 2.63 70 27.2 No No
6 empty 2.39 65.2 19.4 No No
7 empty 2.19 78.5 13.2 No No
8 empty 1.74 63.7 15.8 No No
9 empty 1.89 73.2 11.3 No No
10 empty 2.06 62.8 16.7 No No
2GNL_A cAMP-dependent protein kinase catalytic subunit alpha Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.9 70.9 47.3 Yes Yes
2 empty 2.07 63.2 20.3 No No
3 empty 2.5 71.1 17.9 No No
4 empty 2.29 80.1 17.9 No No
5 empty 2.13 65.7 14.5 No No
6 empty 2.11 63.4 15 No No
7 empty 1.84 60.6 17.8 No No
8 empty 2.19 72.9 16 No No
9 empty 2.39 65.8 21.1 No No
10 empty 2.24 70.9 10.9 No No
2UZW_E cAMP-dependent protein kinase catalytic subunit alpha Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.92 75.4 34.5 Yes Yes
2 empty 1.97 68.2 29.7 No No
3 empty 2.24 67.8 27.9 No No
4 empty 2.31 72.9 21.3 No No
5 empty 2.39 59.6 32.6 No No
6 empty 2 66.5 22.3 No No
7 empty 2.18 79.4 14.3 No No
8 empty 1.81 62.1 16.7 No No
9 empty 2.14 66.9 15.7 No No
10 empty 1.94 66.7 18.1 No No
3ZO4_A cAMP-dependent protein kinase catalytic subunit alpha Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.91 75 35.5 Yes Yes
2 bound 1.96 65.7 28.4 No No
3 bound 2.25 62.7 18.4 No No
4 empty 2.31 72.2 16.3 No No
5 empty 2.01 64.2 16.1 No No
6 empty 2.42 63.2 21 No No
7 empty 2.41 66.9 19.9 No No
8 empty 1.81 62.7 17.7 No No
9 empty 2 66.3 15.1 No No
10 empty 2.27 76.4 14.8 No No
2OH0_E cAMP-dependent protein kinase catalytic subunit alpha Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.87 72.8 45.1 Yes Yes
2 empty 1.98 68.1 30 No No
3 empty 2.28 70.4 28.5 No No
4 empty 2.5 63.3 25.7 No No
5 empty 2.36 73.8 18.2 No No
6 empty 2.08 68.2 20.7 No No
7 empty 2.19 77.1 13.2 No No
8 empty 1.88 62 15.7 No No
9 empty 2.08 74.9 9.7 No No
10 empty 2.35 57.4 11.9 No No
4IE9_A cAMP-dependent protein kinase catalytic subunit alpha Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.85 74.4 35.4 Yes Yes
2 empty 2.14 68 30 No No
3 empty 2.4 60.5 26.7 No No
4 empty 2.47 70.3 21.7 No No
5 empty 2.7 71 18.2 No No
6 empty 2.56 64.1 21 No No
7 empty 2.09 65.3 17.6 No No
8 empty 1.96 61.7 13.9 No No
9 empty 2.24 72.7 11.5 No No
10 empty 2.09 65.7 15.4 No No
1Q61_A cAMP-dependent protein kinase catalytic subunit alpha Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.94 72.9 35.9 Yes Yes
2 bound 2.01 67.6 25.9 No No
3 empty 2.63 68.5 24.9 No No
4 empty 2.33 61.6 23.4 No No
5 empty 2.22 66.1 31.4 No No
6 empty 2.39 63.7 20.7 No No
7 empty 1.84 67.1 17 No No
8 empty 2.22 76.4 12.7 No No
9 empty 1.93 68 11.6 No No
10 empty 2.22 65.1 17.5 No No
2C1A_A cAMP-dependent protein kinase catalytic subunit alpha Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.95 72.2 34.1 Yes Yes
2 empty 2.08 61.2 28.6 No No
3 empty 2.76 70.2 22 No No
4 empty 2.34 68.8 16.3 No No
5 empty 2.27 62.8 23.3 No No
6 empty 1.91 65.7 13.7 No No
7 bound 2.28 57.4 19.7 No No
8 empty 1.46 72.8 13.6 No No
9 empty 1.88 63.7 15.1 No No
10 empty 2.68 60.8 22.1 No No
3E8C_A cAMP-dependent protein kinase catalytic subunit alpha Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.7 72.3 47.7 Yes Yes
2 empty 2.16 65.7 35.5 No No
3 empty 2.12 66.1 31.8 No No
4 empty 2.55 71.6 18.7 No No
5 empty 2.17 67.9 17.8 No No
6 empty 2.3 62 23.4 No No
7 empty 2.07 74 12.2 No No
8 empty 1.77 68.4 12.8 No No
9 empty 1.99 68 13.2 No No
10 empty 2.32 65.3 13.2 No No
1Q24_A cAMP-dependent protein kinase catalytic subunit alpha Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.85 71 40.8 Yes Yes
2 empty 2.2 66.9 27.7 No No
3 empty 2.58 68 28.8 No No
4 empty 2.45 62.2 28.9 No No
5 empty 2.05 65.4 20.5 No No
6 empty 2.36 62.5 24.2 No No
7 empty 1.96 71.8 11.1 No No
8 empty 1.74 75.4 14.6 No No
9 empty 2.19 65 15.1 No No
10 empty 2.25 73.6 10.9 No No
4C36_A cAMP-dependent protein kinase catalytic subunit alpha Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.11 62.1 34.7 Yes No
2 empty 1.93 64.7 23.8 No No
3 empty 2.34 66.8 17.4 No No
4 empty 2.13 60.1 23.6 No No
5 empty 2.63 60.4 24.5 No No
6 bound 1.47 97.5 0 Yes No
7 empty 2.13 56.4 19.1 No No
8 empty 2 64.1 18.8 No No
9 empty 1.86 59.3 14.6 No No
10 empty 2 72 11.6 No No
3E8C_B cAMP-dependent protein kinase catalytic subunit alpha Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.74 73.6 47.3 Yes Yes
2 empty 2.28 66.2 34 No No
3 empty 2.12 68.8 24.2 No No
4 empty 2.66 73.6 24.1 No No
5 empty 2.45 62.2 22.1 No No
6 empty 2.08 66 13.8 No No
7 empty 2.12 67 18.5 No No
8 empty 2.31 64.7 21.1 No No
9 empty 2.59 57.8 22.2 No No
10 empty 2.22 74.4 10.9 No No
1YDT_E cAMP-dependent protein kinase catalytic subunit alpha Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.89 74.8 35.9 Yes Yes
2 empty 1.94 71 29.9 No No
3 empty 2.23 69.6 29.4 No No
4 empty 2.42 74.5 23.7 No No
5 empty 2.43 60.6 27 No No
6 empty 2.18 80.4 13 No No
7 empty 2.14 62.5 21.3 No No
8 empty 2.16 63.1 19.3 No No
9 empty 1.89 61.1 16.6 No No
10 empty 1.94 66.3 18 No No
3ZO3_A cAMP-dependent protein kinase catalytic subunit alpha Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.06 72.3 19.1 Yes No
2 bound 2.18 58.4 17 No No
3 empty 1.92 63.2 20.2 No No
4 empty 1.59 57.7 17.8 No No
5 empty 2.15 66.3 17.9 No No
6 empty 2.18 66.1 19.1 No No
7 empty 2.02 59.7 13.9 No No
8 bound 2.3 58.1 19.6 No No
9 bound 1.64 80.1 13.9 No No
10 bound 1.59 97.8 0 Yes No
2UW0_A cAMP-dependent protein kinase catalytic subunit alpha Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.86 67.4 36.1 Yes Yes
2 empty 2.03 60.1 26.4 No No
3 empty 2.73 69.7 21.4 No No
4 empty 2.13 62.3 18.5 No No
5 empty 2.25 64.6 16.7 No No
6 empty 2.14 64.7 19.2 No No
7 empty 1.49 75.2 13.3 No No
8 empty 1.84 58.2 14.7 No No
9 empty 1.73 66.8 11.8 No No
10 empty 2.15 56.2 15.2 No No
2VO0_A cAMP-dependent protein kinase catalytic subunit alpha Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.79 72 32.7 Yes Yes
2 bound 1.97 66.7 33.7 No No
3 empty 2.06 61.8 18.8 No No
4 bound 2.08 60 17.8 No No
5 empty 2.26 63.9 13.3 No No
6 empty 1.86 61 16.6 No No
7 empty 1.95 65.2 13.7 No No
8 empty 2.45 65.1 13.3 No No
9 empty 2.75 73.7 11.5 No No
10 empty 2.09 57.5 14.9 No No
1SVE_A cAMP-dependent protein kinase catalytic subunit alpha Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.83 74.7 35.4 Yes Yes
2 empty 2.27 69.6 24.7 No No
3 empty 2.47 71.3 12.9 No No
4 empty 2.62 69.6 22.1 No No
5 bound 2.02 71.7 18.7 No No
6 empty 2.44 65.7 23.8 No No
7 empty 2.39 65.4 21 No No
8 empty 1.79 63.5 16.6 No No
9 empty 2.03 81.3 12.6 No No
10 empty 1.89 70.8 11.1 No No
3E8C_F cAMP-dependent protein kinase catalytic subunit alpha Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.72 72.8 48.2 Yes Yes
2 empty 2.12 68.7 33.6 No No
3 empty 2.2 66.3 31 No No
4 empty 2.53 71.3 21.8 No No
5 empty 1.74 75 19 No No
6 empty 2.42 65.4 27.9 No No
7 empty 2.19 63.8 18.5 No No
8 empty 2.07 68.7 13.8 No No
9 empty 2.2 78.4 12.7 No No
10 empty 2.27 58.6 16.2 No No
3E8C_E cAMP-dependent protein kinase catalytic subunit alpha Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.72 74.8 47.2 Yes Yes
2 empty 2.04 64.9 28.8 No No
3 empty 2.09 67.3 24.4 No No
4 empty 2.59 70.8 24.9 No No
5 empty 2.08 65.4 16.5 No No
6 empty 2.33 64.5 22.7 No No
7 empty 1.93 61.1 23.3 No No
8 empty 2.26 80.8 11.7 No No
9 empty 2.32 60.7 14 No No
10 empty 2.17 64.6 15.6 No No
5VIB_A cAMP-dependent protein kinase catalytic subunit alpha Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.99 73.3 40.5 Yes Yes
2 empty 1.99 63.9 31.7 No No
3 empty 2.27 60.6 21.8 No No
4 empty 2.43 66.9 19.2 No No
5 empty 2.55 61.4 27.4 No No
6 empty 2.1 65 14.1 No No
7 empty 2.22 72.8 12.5 No No
8 empty 2.07 56.4 17.2 No No
9 empty 1.76 68.8 13.3 No No
10 empty 2.59 59.2 12.6 No No
2UW5_A cAMP-dependent protein kinase catalytic subunit alpha Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.79 67.6 33.2 Yes Yes
2 empty 1.9 63.7 19 No No
3 bound 2.49 67 14.9 No No
4 empty 2.29 62.6 19.7 No No
5 empty 2 60.4 17.8 No No
6 bound 2 64.2 13.9 No No
7 empty 1.45 75.8 12.7 No No
8 empty 1.91 60.7 15 No No
9 empty 2.15 59.4 15.9 No No
10 empty 2.26 68.7 9.1 No No
4C37_A cAMP-dependent protein kinase catalytic subunit alpha Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.84 69.6 33 Yes Yes
2 empty 2.36 68.5 15.8 No No
3 empty 1.88 59.8 17 No No
4 empty 2.25 62.7 16.6 No No
5 empty 2.09 54.7 18.6 No No
6 empty 2.08 64.9 12.9 No No
7 empty 1.88 61.4 13.7 No No
8 empty 1.86 65.3 18.6 No No
9 empty 2.1 65.6 11.8 No No
10 empty 1.98 61.8 15.2 No No
2VO7_A cAMP-dependent protein kinase catalytic subunit alpha Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.81 71.6 33.4 Yes Yes
2 empty 2 59.1 25.1 No No
3 empty 2.45 72 17.3 No No
4 empty 2.16 68.5 14.8 No No
5 empty 2.14 61.1 20.3 No No
6 empty 1.8 59.4 15.6 No No
7 empty 1.97 65 14.1 No No
8 bound 1.56 68.8 13.7 No No
9 empty 2.59 62.9 20.8 No No
10 empty 2.15 78 12.1 No No
2UW8_A cAMP-dependent protein kinase catalytic subunit alpha Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.77 76.6 33.5 Yes Yes
2 empty 2 68.2 29.7 No No
3 empty 2.31 62.2 27.7 No No
4 empty 2.19 66.4 18.8 No No
5 empty 2.68 71.2 17.5 No No
6 empty 2.09 67.1 19.5 No No
7 empty 2.09 63.5 19.8 No No
8 empty 2.42 60 21.3 No No
9 empty 2 60.5 16.7 No No
10 empty 2.2 74.1 12.3 No No
3E8E_E cAMP-dependent protein kinase catalytic subunit alpha Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.61 74.9 47.1 Yes Yes
2 empty 2.09 66.5 34.3 No No
3 empty 2.25 69.4 23.4 No No
4 empty 2.69 71.4 19.7 No No
5 empty 2.25 63.6 20.7 No No
6 empty 2.07 64.4 15.4 No No
7 empty 2.21 73.4 12.8 No No
8 empty 1.88 69.2 11.2 No No
9 empty 2.19 61.8 15.5 No No
10 empty 2.14 65.1 15.4 No No
3E8C_C cAMP-dependent protein kinase catalytic subunit alpha Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.72 71.4 48.5 Yes Yes
2 empty 2.21 66.6 36.1 No No
3 empty 2.29 67.5 23.3 No No
4 empty 2.53 69.8 18.8 No No
5 empty 2.11 64.9 15.9 No No
6 empty 2.18 65.7 17.7 No No
7 empty 2.2 62.8 25.3 No No
8 empty 2.22 74.6 12.4 No No
9 empty 2.14 68.7 12.6 No No
10 empty 1.79 66.5 12.1 No No
2UVX_A cAMP-dependent protein kinase catalytic subunit alpha Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.72 73.8 43.7 Yes Yes
2 empty 2.13 66 25.7 No No
3 empty 2.39 63.6 26.1 No No
4 empty 2.28 62.7 24.8 No No
5 empty 2.19 67.1 14.2 No No
6 empty 1.62 79.1 14.2 No No
7 empty 2.16 62 17.8 No No
8 empty 2.03 61.2 14.6 No No
9 empty 1.94 66.1 13.1 No No
10 empty 2.11 72.7 16.1 No No
1XH6_A cAMP-dependent protein kinase catalytic subunit alpha Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.92 73.4 36.7 Yes Yes
2 empty 2.22 70.6 23.3 No No
3 empty 2.58 66.5 18.2 No No
4 empty 2.29 64.9 18.1 No No
5 empty 2.54 67.2 20.9 No No
6 empty 2.08 66.9 15.2 No No
7 empty 1.99 65.5 16.3 No No
8 empty 1.7 62.2 16.9 No No
9 empty 2.09 74.6 13.7 No No
10 empty 1.78 67.4 13.6 No No
2F7E_E cAMP-dependent protein kinase catalytic subunit alpha Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.9 73.1 35.4 Yes Yes
2 empty 2.26 72.6 31.5 No No
3 empty 2.53 62.1 27.1 No No
4 empty 2.58 72.1 19.6 No No
5 empty 2.02 66.5 19.9 No No
6 empty 2.26 66.4 19.8 No No
7 empty 2.16 67.3 18.1 No No
8 empty 1.87 62.6 15.7 No No
9 empty 1.98 84.7 13.2 Yes No
10 empty 2.06 75.9 10.4 No No
4Z84_A cAMP-dependent protein kinase catalytic subunit alpha Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.85 71.5 33.7 Yes Yes
2 bound 2.24 69.8 18.2 No No
3 empty 2.32 64.2 13.7 No No
4 empty 2.06 63.8 13.2 No No
5 empty 1.75 61.2 15 No No
6 empty 2.16 66.3 13.4 No No
7 empty 1.93 62.6 14 No No
8 empty 1.86 64.7 12.5 No No
9 empty 2 73.5 10.2 No No
10 empty 2.23 58.9 15.1 No No
2UZT_A cAMP-dependent protein kinase catalytic subunit alpha Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.85 71.2 46.9 Yes Yes
2 empty 2.06 67.4 25.5 No No
3 empty 2.43 68.8 24.8 No No
4 empty 2.34 69.1 23.3 No No
5 empty 2.27 59.9 22 No No
6 empty 2.4 65.4 21.8 No No
7 empty 2.3 70.7 11 No No
8 empty 2.04 71.1 11.6 No No
9 empty 1.84 66 14.1 No No
10 empty 2.4 62.8 13.3 No No
4C34_A cAMP-dependent protein kinase catalytic subunit alpha Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.73 75.7 39.8 Yes Yes
2 bound 2.05 67.2 32.8 No No
3 empty 2.2 66 30.5 No No
4 empty 2.19 67 31.5 No No
5 empty 2.59 75.1 14.2 No No
6 empty 2.28 64.6 16.1 No No
7 empty 2.21 63.9 16.7 No No
8 empty 1.89 55.9 19 No No
9 empty 2.16 67.2 17.2 No No
10 empty 1.99 74.7 14.8 No No
2F7X_E cAMP-dependent protein kinase catalytic subunit alpha Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.87 71.8 34.9 Yes Yes
2 empty 2.03 66.4 22.1 No No
3 empty 2.34 70.3 24.1 No No
4 empty 2.48 75.3 19.9 No No
5 empty 2.28 64.8 23 No No
6 empty 2.12 63.8 20.4 No No
7 empty 2.35 81.8 13.5 No No
8 empty 1.5 75.4 13.6 No No
9 empty 1.94 64.9 17.9 No No
10 empty 2.06 73.1 12 No No
1SVH_A cAMP-dependent protein kinase catalytic subunit alpha Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.92 75.7 33.4 Yes Yes
2 empty 2.06 70.4 36.8 No No
3 empty 1.97 66.9 25.6 No No
4 empty 2.35 73.9 16.2 No No
5 empty 2.29 64.7 18.5 No No
6 empty 2.01 61.3 16.8 No No
7 empty 2.3 65.4 18.3 No No
8 empty 2 66.7 16.7 No No
9 empty 1.78 70 12.2 No No
10 empty 1.88 70.8 14.9 No No
6E99_A cAMP-dependent protein kinase catalytic subunit alpha Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.85 73.2 47.4 Yes Yes
2 empty 2.27 70.4 28.4 No No
3 empty 2.04 65.7 27.2 No No
4 empty 2.46 62.8 30.8 No No
5 empty 2.62 70.8 23.5 No No
6 empty 2.31 57.9 26.3 No No
7 empty 2.27 68.2 15.9 No No
8 empty 2.12 67.7 14.4 No No
9 empty 1.97 67 13.7 No No
10 empty 2.16 60.9 15.8 No No
2OJF_E cAMP-dependent protein kinase catalytic subunit alpha Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.9 73 35.4 Yes Yes
2 empty 2.01 69.5 29.6 No No
3 empty 2.27 70.7 19.5 No No
4 empty 2.29 71.1 18.3 No No
5 empty 1.92 62.9 14.8 No No
6 empty 2.17 77.6 12.3 No No
7 empty 2.04 63.2 19.7 No No
8 empty 2.2 62.1 17.6 No No
9 empty 2 63.9 16.9 No No
10 empty 2.12 71.2 11.5 No No
2UW6_A cAMP-dependent protein kinase catalytic subunit alpha Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.79 70.4 34.1 Yes Yes
2 empty 1.84 62.1 16.7 No No
3 empty 2.11 66.1 13.1 No No
4 bound 2.75 69.7 14.1 No No
5 empty 1.47 74.1 14.7 No No
6 empty 2.17 64.4 18.1 No No
7 empty 1.88 62.5 16.4 No No
8 empty 2.22 57.6 16.5 No No
9 empty 1.58 70.6 10.6 No No
10 empty 1.93 63.4 16.6 No No
3DND_A cAMP-dependent protein kinase catalytic subunit alpha Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.93 71.8 45.2 Yes Yes
2 empty 2.19 65.8 29.3 No No
3 empty 2.39 68.4 22.6 No No
4 empty 2.66 72 20.7 No No
5 empty 2.49 60.2 26.2 No No
6 empty 2.56 65.1 19.3 No No
7 empty 2.2 76.1 13.8 No No
8 empty 2.03 71.4 13.5 No No
9 empty 2.09 63.1 19.7 No No
10 empty 2.15 60.4 16.9 No No
4C35_A cAMP-dependent protein kinase catalytic subunit alpha Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.74 75 34.4 Yes Yes
2 bound 2.12 65.5 33.5 No No
3 empty 2.09 65.5 20.7 No No
4 empty 2.25 75.7 14 No No
5 empty 2.28 68.8 12.2 No No
6 empty 2.34 63.8 18.4 No No
7 empty 2.03 71.4 12.5 No No
8 empty 1.85 69.3 12.9 No No
9 empty 2.1 64.6 15.4 No No
10 empty 2.18 70.9 17.3 No No
4YXS_A cAMP-dependent protein kinase catalytic subunit alpha Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.98 74.3 34.2 Yes Yes
2 empty 2.16 61.6 28.1 No No
3 empty 2.5 59.8 26.9 No No
4 empty 2.42 68.7 30.2 No No
5 empty 2.61 77.5 11.6 No No
6 empty 2.04 65.4 16.1 No No
7 empty 2.39 65.3 20.3 No No
8 empty 1.63 79.2 15.2 No No
9 empty 1.89 63.2 14.3 No No
10 empty 2.29 71.6 14.2 No No
3E8E_P cAMP-dependent protein kinase catalytic subunit alpha Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.72 77 33.9 Yes Yes
2 empty 2.14 67.2 33.9 No No
3 empty 2.23 68.6 35.7 No No
4 empty 2.63 74.4 20.7 No No
5 empty 2.14 67.1 17.9 No No
6 empty 2.32 62.5 20.7 No No
7 empty 2.11 71.8 11.9 No No
8 empty 2.05 65.4 15.7 No No
9 empty 1.89 67.9 14.8 No No
10 empty 2.11 65.2 12.4 No No
3DNE_A cAMP-dependent protein kinase catalytic subunit alpha Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.84 70.6 44.1 Yes Yes
2 empty 2.19 67.2 28.9 No No
3 empty 2.33 60 29.7 No No
4 empty 2.32 68.5 24.1 No No
5 empty 2.64 72.9 19.9 No No
6 empty 2.12 77.1 13.7 No No
7 empty 2.41 65.8 20.4 No No
8 empty 1.95 69.3 14 No No
9 empty 1.87 62.5 15.3 No No
10 empty 2.34 58 11.3 No No
2GNF_A cAMP-dependent protein kinase catalytic subunit alpha Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.73 69.4 35.5 Yes Yes
2 empty 2.12 65.1 18.2 No No
3 empty 2.3 63.8 16.6 No No
4 bound 2.84 63.2 15.6 No No
5 empty 2.12 65.6 19.2 No No
6 empty 2.06 62.6 14.3 No No
7 empty 2.26 57.7 19.1 No No
8 empty 1.85 61.8 14.7 No No
9 empty 1.99 63 14.2 No No
10 empty 2.13 55.1 18.1 No No
3KKV_A cAMP-dependent protein kinase catalytic subunit alpha Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.59 72 48.1 Yes Yes
2 empty 2.16 65.8 30.2 No No
3 empty 2.24 68.7 22.9 No No
4 empty 2.69 70.2 24.3 No No
5 empty 2.19 63.7 22.4 No No
6 empty 2.32 64.4 14.7 No No
7 empty 2.22 64.8 22.9 No No
8 empty 1.99 64.5 18 No No
9 empty 2.27 72.6 10.2 No No
10 empty 2.09 66.3 12.8 No No
2JDV_A cAMP-dependent protein kinase catalytic subunit alpha Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.83 72.3 47.6 Yes Yes
2 empty 2.13 61.6 25.3 No No
3 empty 2.22 71.8 27.1 No No
4 empty 2.57 72 16.5 No No
5 empty 2.24 66.7 17.5 No No
6 empty 2.52 59.3 25.7 No No
7 empty 1.93 62 16.2 No No
8 empty 2.49 63 19.8 No No
9 empty 1.99 65 16.3 No No
10 empty 2.11 69.6 13.3 No No
2UW4_A cAMP-dependent protein kinase catalytic subunit alpha Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.92 73 39.6 Yes Yes
2 empty 2.13 62.1 25.6 No No
3 empty 2.32 66.3 17.5 No No
4 empty 2.18 65.6 18.6 No No
5 empty 2.02 64.4 14.7 No No
6 empty 1.66 69.8 18.8 No No
7 empty 2.08 69.9 14.2 No No
8 empty 1.89 61.1 15.7 No No
9 empty 2.18 63.4 17.3 No No
10 empty 2.35 61.8 21.2 No No
1YDS_E cAMP-dependent protein kinase catalytic subunit alpha Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.94 73 46.6 Yes Yes
2 empty 2.22 69.1 22.3 No No
3 empty 2.22 65 21.3 No No
4 empty 2.41 63.2 26 No No
5 empty 2.46 71.5 20 No No
6 empty 2.21 82.5 14 No No
7 empty 2.02 62.6 21.9 No No
8 empty 1.57 76 13.8 No No
9 empty 2 61.8 13.9 No No
10 empty 2.2 76 12 No No
3E8C_D cAMP-dependent protein kinase catalytic subunit alpha Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.74 72.3 48 Yes Yes
2 empty 2.18 72 31.5 No No
3 empty 2.12 69.5 25.2 No No
4 empty 2.32 72.1 18.4 No No
5 empty 2.15 65.2 29.4 No No
6 empty 1.97 54.1 18.2 No No
7 empty 2.07 66.5 13.7 No No
8 empty 2.17 79.9 11.6 No No
9 empty 2.27 57.3 15.1 No No
10 empty 1.79 70 12.1 No No
4AXA_A cAMP-dependent protein kinase catalytic subunit alpha Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.98 70.6 35.8 Yes Yes
2 empty 2.01 68.4 28.6 No No
3 empty 2.25 67.8 26.8 No No
4 empty 2.74 71.5 22.1 No No
5 empty 2.23 64.1 23.4 No No
6 empty 2.02 69.2 12.4 No No
7 empty 2.23 71.1 20.3 No No
8 empty 2.12 61.1 19 No No
9 empty 1.78 59.7 15.2 No No
10 empty 2.46 65.9 14.6 No No
4C38_A cAMP-dependent protein kinase catalytic subunit alpha Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.95 74 46 Yes Yes
2 empty 2 62.8 24.6 No No
3 bound 2.09 72.4 15.4 No No
4 empty 1.77 68.4 16.7 No No
5 empty 2.19 60.9 17.9 No No
6 empty 1.82 64 14.3 No No
7 empty 1.49 75.2 14.5 No No
8 empty 2.1 71.5 14.2 No No
9 empty 2.05 65.8 14.2 No No
10 empty 2.17 70.6 12.5 No No
2VNY_A cAMP-dependent protein kinase catalytic subunit alpha Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.82 72.2 34.9 Yes Yes
2 empty 2.09 67.8 30.1 No No
3 empty 2.71 77.4 16 No No
4 empty 2.28 66.9 20.4 No No
5 empty 2.22 70.7 13.2 No No
6 empty 2.14 67.4 13.2 No No
7 empty 2.51 62.7 20.4 No No
8 empty 2.15 71.3 15.8 No No
9 empty 1.97 58.5 16.8 No No
10 empty 2.11 59.8 15.7 No No
3E8E_I cAMP-dependent protein kinase catalytic subunit alpha Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.67 73.5 47.3 Yes Yes
2 empty 2.17 64.4 31.2 No No
3 empty 2.23 68 30.4 No No
4 empty 2.51 72.7 21.2 No No
5 empty 1.75 72.2 18.3 No No
6 empty 2.48 63.7 25.4 No No
7 empty 2.07 78 12.1 No No
8 empty 1.86 66.4 14.3 No No
9 empty 1.94 68.7 13.5 No No
10 empty 2.13 63.4 14.9 No No
4C33_A cAMP-dependent protein kinase catalytic subunit alpha Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.94 74.5 44.9 Yes Yes
2 empty 2.06 67.3 24.3 No No
3 empty 2.02 62.3 23.8 No No
4 empty 2.26 60.7 21.6 No No
5 empty 2.18 64.9 17.7 No No
6 empty 1.97 61.5 15.3 No No
7 empty 1.88 69.2 17.6 No No
8 empty 2.16 70.1 11.9 No No
9 empty 2.32 57.1 18.9 No No
10 empty 1.93 84 15.7 No No
2UW7_A cAMP-dependent protein kinase catalytic subunit alpha Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.88 69.9 46.2 Yes Yes
2 empty 2.08 67.2 29.4 No No
3 empty 2.71 77.2 18.7 No No
4 empty 2.16 69.3 11.4 No No
5 empty 2.23 65.9 21 No No
6 empty 2.45 63.6 23.8 No No
7 empty 2.27 60.9 15.6 No No
8 empty 2.18 63.1 18.1 No No
9 empty 2.07 63.1 16.7 No No
10 empty 1.96 65.4 15.7 No No
3E8E_L cAMP-dependent protein kinase catalytic subunit alpha Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.62 75.5 47.2 Yes Yes
2 empty 2.04 65.3 28.6 No No
3 empty 2.09 66.4 14.1 No No
4 empty 2.57 74.9 14.5 No No
5 empty 2.22 64.8 21 No No
6 empty 2.41 64.3 21.8 No No
7 empty 2.01 63.2 14.7 No No
8 empty 2.24 71.6 11.6 No No
9 empty 1.91 69.4 11.7 No No
10 empty 2.36 61 13.7 No No
1Q8W_A cAMP-dependent protein kinase catalytic subunit alpha Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.86 73.4 37.6 Yes Yes
2 empty 2.04 68.4 31 No No
3 empty 2.16 62 27.9 No No
4 empty 2.22 70.5 18.9 No No
5 empty 2.23 63.3 22.1 No No
6 empty 2.26 66.1 19.1 No No
7 empty 2.21 74.2 12.8 No No
8 empty 2.17 68.4 15.4 No No
9 empty 2.52 68.6 17 No No
10 empty 2.33 66.5 20.8 No No
1XH9_A cAMP-dependent protein kinase catalytic subunit alpha Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.98 73.4 35 Yes Yes
2 bound 2.12 66.2 22.7 No No
3 empty 2.28 60.2 21.7 No No
4 empty 2.37 68.4 26.1 No No
5 bound 2.4 75.4 18.2 No No
6 empty 2.43 63.4 23.3 No No
7 empty 2.18 62.5 16.2 No No
8 empty 1.81 65.1 15.6 No No
9 empty 2.18 70.3 12.9 No No
10 empty 2.34 73.7 14.2 No No
4IJ9_A cAMP-dependent protein kinase catalytic subunit alpha Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.83 70.5 35.8 Yes Yes
2 empty 2.06 65.1 29.4 No No
3 empty 2.64 69.6 26.6 No No
4 empty 2.27 67.9 19.2 No No
5 empty 2.52 67.3 18.5 No No
6 empty 2.02 62.8 15.9 No No
7 empty 2.11 62 18.6 No No
8 empty 2.5 62.5 25.7 No No
9 empty 2.14 60.9 16 No No
10 empty 2.14 74.1 9.9 No No
1XH7_A cAMP-dependent protein kinase catalytic subunit alpha Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.91 74.1 35.4 Yes Yes
2 empty 1.83 66.6 28.3 No No
3 empty 2.51 74.7 20.2 No No
4 empty 2.64 71.3 20.6 No No
5 empty 2.43 64.4 26.2 No No
6 empty 2.37 64 22.7 No No
7 empty 2.27 62.6 19.7 No No
8 empty 1.7 61.3 15.8 No No
9 empty 1.92 63 15.9 No No
10 empty 2.15 75.5 9.4 No No
1VEB_A cAMP-dependent protein kinase catalytic subunit alpha Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.93 74.7 32.6 Yes Yes
2 empty 2.17 67.5 34.2 No No
3 empty 2.37 69.6 19.1 No No
4 empty 2.68 67.2 24.3 No No
5 empty 2.36 62.9 24.1 No No
6 empty 2.05 80.5 13.2 No No
7 empty 2.64 64.3 20.3 No No
8 empty 1.84 62.9 17.1 No No
9 empty 1.97 61.7 15.2 No No
10 empty 1.76 74 9.9 No No
5VHB_A cAMP-dependent protein kinase catalytic subunit alpha Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.34 67.8 43.2 Yes No
2 bound 1.85 71.2 35.9 No No
3 empty 2.7 69.9 22.6 No No
4 empty 2.31 58.8 16.6 No No
5 empty 2.28 64.7 22.6 No No
6 empty 2.39 62.7 22.6 No No
7 empty 2.24 67.3 15.1 No No
8 empty 2.21 59.1 14.7 No No
9 empty 1.92 60.2 15.1 No No
10 empty 1.78 60.3 18.1 No No
6E9L_A cAMP-dependent protein kinase catalytic subunit alpha Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.77 72.3 47.2 Yes Yes
2 empty 2.11 65.2 33.2 No No
3 empty 2.72 73.7 16.8 No No
4 empty 2.32 71.3 20.4 No No
5 empty 2.52 65.4 21.6 No No
6 empty 2.27 66 23 No No
7 empty 2.12 68.6 13.6 No No
8 empty 1.89 60.2 16.5 No No
9 empty 2.42 80.3 12 No No
10 empty 2.16 62.6 17.6 No No
1SVG_A cAMP-dependent protein kinase catalytic subunit alpha Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.86 75.6 33.5 Yes Yes
2 empty 2.17 72.5 24.2 No No
3 empty 2.25 68.6 26.5 No No
4 empty 2.37 61.4 26.3 No No
5 empty 2.51 68.2 23.7 No No
6 empty 1.87 68.8 19 No No
7 empty 2.18 60.4 18.4 No No
8 empty 2.36 64.2 21.3 No No
9 empty 1.84 64.3 16.6 No No
10 empty 1.96 68.2 12.1 No No
2JDS_A cAMP-dependent protein kinase catalytic subunit alpha Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.88 73.5 36 Yes Yes
2 empty 2.15 65.6 26.2 No No
3 empty 2.39 71.8 20.1 No No
4 empty 2.37 63.6 27.8 No No
5 empty 2.21 66.9 17.8 No No
6 empty 2.58 70.7 17.7 No No
7 empty 2.53 62.9 21.3 No No
8 empty 1.8 60.7 16.3 No No
9 empty 2.17 74.4 10.9 No No
10 empty 2.25 67.9 16.2 No No
5VI9_A cAMP-dependent protein kinase catalytic subunit alpha Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.8 76.4 26.8 Yes Yes
2 empty 1.89 67.5 26.4 No No
3 empty 2.04 61.3 33.3 No No
4 empty 2.42 65.2 33 No No
5 empty 2.11 64.9 30.2 No No
6 empty 2.1 63.3 15 No No
7 empty 2.22 57.7 15.9 No No
8 empty 2.26 71.4 19.8 No No
9 empty 1.87 66.2 15.4 No No
10 empty 2.19 78.1 12.9 No No
1YDR_E cAMP-dependent protein kinase catalytic subunit alpha Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.78 72.1 34.4 Yes Yes
2 empty 2.33 67.9 20.4 No No
3 empty 2.16 65.2 25.3 No No
4 empty 2.37 60.8 27 No No
5 empty 2.59 74.9 20.3 No No
6 empty 2.2 81.8 11.9 No No
7 empty 1.92 61.5 17.2 No No
8 empty 1.57 74.9 14.1 No No
9 empty 2.06 76 13.2 No No
10 empty 2.05 60.9 20.2 No No
3AG9_A cAMP-dependent protein kinase catalytic subunit alpha Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.84 76.9 32.2 Yes Yes
2 empty 2.04 65.2 25.9 No No
3 empty 2.83 71 22.4 No No
4 empty 2.11 62.6 19.5 No No
5 empty 2.09 69.1 16.3 No No
6 empty 2.3 72.2 22.7 No No
7 empty 2.01 64.4 14.4 No No
8 empty 2.16 62 14.2 No No
9 empty 1.92 64.4 15.1 No No
10 empty 2.18 69.4 16.2 No No
2VO3_A cAMP-dependent protein kinase catalytic subunit alpha Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.78 73.1 35.8 Yes Yes
2 empty 2.06 66.2 31.1 No No
3 empty 2.44 63.5 26 No No
4 empty 2.71 74.8 18.4 No No
5 empty 2.28 67.7 16.7 No No
6 empty 2.16 66.1 13.2 No No
7 empty 2.42 63.3 19.3 No No
8 empty 2.14 62.4 14.3 No No
9 empty 1.89 62.6 15.3 No No
10 empty 2.16 74.5 13.9 No No
2UVY_A cAMP-dependent protein kinase catalytic subunit alpha Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.85 73.5 36.5 Yes Yes
2 empty 2.12 66.7 30.2 No No
3 empty 2.4 66.2 25.2 No No
4 empty 2.21 61.8 16.8 No No
5 empty 2.25 67.7 14.9 No No
6 empty 2 61.2 17.9 No No
7 empty 2.17 67.5 12 No No
8 empty 2.23 64.3 19.8 No No
9 empty 2.19 75.1 14.3 No No
10 empty 2.1 69.5 11.3 No No
4YXR_A cAMP-dependent protein kinase catalytic subunit alpha Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.85 73 36.1 Yes Yes
2 empty 2.22 66.2 29 No No
3 empty 2.69 70.4 19.2 No No
4 empty 2.36 68.7 22.1 No No
5 empty 2.5 66.5 19.5 No No
6 empty 2.07 68.7 13.1 No No
7 empty 2.5 57.7 25.8 No No
8 empty 2.22 63.2 19 No No
9 empty 1.83 61.5 16.1 No No
10 empty 2.23 73.7 11.1 No No
2GNJ_A cAMP-dependent protein kinase catalytic subunit alpha Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.85 69.7 37.8 Yes Yes
2 empty 2.04 67.1 26.4 No No
3 empty 2.36 67.7 18.6 No No
4 empty 2.49 73.9 20.7 No No
5 empty 2.12 67.5 18.8 No No
6 empty 2.4 65.7 18.7 No No
7 empty 2.43 73.6 11.5 No No
8 empty 1.91 62.1 16.3 No No
9 empty 1.86 75.9 15.1 No No
10 empty 1.97 67.9 13.9 No No
3BWJ_A cAMP-dependent protein kinase catalytic subunit alpha Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.8 70.1 37.1 Yes Yes
2 empty 2.43 67.7 33.2 No No
3 empty 2.37 70.8 20.9 No No
4 bound 2.34 63.4 25.8 No No
5 empty 2.56 67.1 22.8 No No
6 empty 2.39 61.6 22.3 No No
7 empty 2.34 67.8 22 No No
8 empty 2.54 61.7 21.2 No No
9 empty 2.13 64.6 15.9 No No
10 empty 2.24 79.5 13.3 No No
1SZM_B cAMP-dependent protein kinase catalytic subunit alpha Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.82 75 32 Yes Yes
2 empty 2 66.5 32.3 No No
3 empty 2.16 65.8 32.8 No No
4 empty 2.64 65 26.1 No No
5 empty 2.47 73.1 20.4 No No
6 empty 1.69 68.8 16.6 No No
7 empty 2.04 73.4 14 No No
8 empty 2.26 69.4 16 No No
9 empty 2.3 61.4 14.5 No No
10 empty 2.14 61.5 18.6 No No
3E8E_B cAMP-dependent protein kinase catalytic subunit alpha Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.71 77.7 33.5 Yes Yes
2 empty 2.2 65.8 24.4 No No
3 empty 2.28 67.7 23.6 No No
4 empty 2.72 72.2 16.7 No No
5 empty 2.13 69.5 15.3 No No
6 empty 2.21 64.1 20.3 No No
7 empty 2.15 80.2 14.5 No No
8 empty 1.54 80.9 15.4 No No
9 empty 2.11 68.6 11.7 No No
10 empty 1.75 67.7 10.1 No No
2UVZ_A cAMP-dependent protein kinase catalytic subunit alpha Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.71 73.6 39.5 Yes Yes
2 empty 2.07 66.6 29.7 No No
3 empty 2.78 68.3 21 No No
4 empty 2.11 70.4 19.7 No No
5 empty 2.13 63.9 17.2 No No
6 empty 2.28 65.4 17.3 No No
7 empty 2.25 63.7 16.1 No No
8 empty 1.87 61 17.4 No No
9 empty 2.07 61.1 16.5 No No
10 empty 2.1 60.2 15.7 No No
2C1B_A cAMP-dependent protein kinase catalytic subunit alpha Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.94 72.6 36.3 Yes Yes
2 empty 2.05 67.5 27.9 No No
3 empty 2.39 62 28 No No
4 empty 2.43 72.1 18.8 No No
5 empty 2.54 72 18.4 No No
6 empty 2.41 61.3 21.5 No No
7 empty 1.98 60.5 15.2 No No
8 empty 2.03 62.4 15.6 No No
9 empty 2.38 74.3 12.7 No No
10 empty 2 70.3 10.2 No No
2GFC_A cAMP-dependent protein kinase catalytic subunit alpha Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.16 68.2 27.6 Yes No
2 empty 1.89 75.8 34.6 No No
3 empty 2.21 71.6 24.8 No No
4 empty 2.1 63.6 23.1 No No
5 empty 2.46 71.3 24 No No
6 empty 2.03 67.8 17.4 No No
7 empty 1.95 63.7 14.7 No No
8 empty 2.1 63.4 17.7 No No
9 empty 2.29 60.6 17.6 No No
10 empty 2.15 66.5 15.3 No No
2VO6_A cAMP-dependent protein kinase catalytic subunit alpha Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.93 71 32.6 Yes Yes
2 empty 2.14 67.9 32.6 No No
3 empty 2.48 65.4 26 No No
4 empty 2.8 73.7 17.1 No No
5 empty 2.2 65.5 16.2 No No
6 empty 2.13 65 11.7 No No
7 empty 1.89 60.9 15.5 No No
8 empty 2.14 62.3 19.6 No No
9 empty 2.2 73.2 13.8 No No
10 empty 2.24 61.9 19.6 No No
1SMH_A cAMP-dependent protein kinase catalytic subunit alpha Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2 76.6 31.5 Yes Yes
2 bound 2.2 67.3 36.1 No No
3 empty 2.54 68.8 37.2 No No
4 bound 2.66 70 20.6 No No
5 empty 2.35 60.4 23.1 No No
6 empty 2.39 64.1 20.8 No No
7 empty 2.12 77.3 14.5 No No
8 empty 2.21 60 16.3 No No
9 empty 1.91 65.1 14.4 No No
10 bound 2.06 65.7 13.4 No No
2GNG_A cAMP-dependent protein kinase catalytic subunit alpha Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.81 70.9 46.2 Yes Yes
2 empty 2.4 70.7 20.9 No No
3 empty 2.23 72.2 19.3 No No
4 empty 2.42 69.6 21 No No
5 empty 2.55 69.8 25.7 No No
6 empty 2.12 67.8 18.7 No No
7 empty 1.77 62.5 17.9 No No
8 empty 2.4 62.2 19.8 No No
9 empty 1.96 66.9 13.4 No No
10 empty 2.15 62.4 17.2 No No
2VNW_A cAMP-dependent protein kinase catalytic subunit alpha Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.75 73.7 35.5 Yes Yes
2 empty 1.99 68.2 30.3 No No
3 empty 2.19 64 17.6 No No
4 empty 2.68 74.8 14.8 No No
5 empty 2.24 73.3 14.3 No No
6 empty 2.1 64 18.2 No No
7 empty 2.55 65.2 20.6 No No
8 empty 1.89 61.3 14.1 No No
9 empty 2.21 67.5 14.8 No No
10 empty 2.2 67.3 13.7 No No
1XH4_A cAMP-dependent protein kinase catalytic subunit alpha Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.93 76.2 32.9 Yes Yes
2 empty 2.16 71 25 No No
3 empty 2.11 69 31.3 No No
4 empty 2.53 69 20.3 No No
5 empty 2.35 65.3 16.1 No No
6 empty 2.36 67.8 22.1 No No
7 empty 1.74 62.8 15.4 No No
8 empty 2.18 65.7 15.2 No No
9 empty 2.13 57.9 12.9 No No
10 empty 1.67 71 10.1 No No
3E8E_A cAMP-dependent protein kinase catalytic subunit alpha Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.03 65.3 36.2 Yes No
2 bound 1.66 77.5 34.8 Yes No
3 empty 2.26 70.4 28.8 No No
4 empty 2.62 73.5 18.8 No No
5 empty 2.33 65.2 29.9 No No
6 empty 2.08 62 21.6 No No
7 empty 2.17 68.3 17.2 No No
8 empty 2.09 78.6 14.1 No No
9 empty 1.99 64.6 15.8 No No
10 empty 1.87 65.4 15.4 No No
3ZO1_A cAMP-dependent protein kinase catalytic subunit alpha Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.91 69.7 32 Yes Yes
2 empty 1.83 64.7 23.7 No No
3 bound 2.07 60.7 17.4 No No
4 empty 2.34 70.7 16.9 No No
5 bound 1.55 67.5 18.7 No No
6 empty 2.12 63.4 22 No No
7 bound 2.21 65.2 15.2 No No
8 empty 2.56 60.6 21.4 No No
9 empty 1.88 61.6 15.3 No No
10 empty 1.98 67.5 14.4 No No
2GNI_A cAMP-dependent protein kinase catalytic subunit alpha Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.01 69.6 48.4 Yes Yes
2 empty 2.05 66.1 21.5 No No
3 empty 2.11 72.7 22.3 No No
4 empty 2.23 70.9 23.5 No No
5 empty 2 76.1 21.2 No No
6 empty 2.11 67.2 20.5 No No
7 empty 2.4 65.2 21.1 No No
8 empty 2 69.3 14.8 No No
9 empty 1.84 62.5 17.2 No No
10 empty 2.55 58 25.9 No No
1XH8_A cAMP-dependent protein kinase catalytic subunit alpha Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.89 71.3 48 Yes Yes
2 empty 2.35 68.2 24.4 No No
3 empty 2.66 70.5 20.1 No No
4 empty 2.01 72.4 21 No No
5 empty 2.05 64 18.9 No No
6 empty 2.24 65.7 14 No No
7 empty 2.66 61.7 26 No No
8 empty 2.35 63.2 19.1 No No
9 empty 2.15 64.9 13 No No
10 empty 2.16 75.1 13.8 No No
3AG9_B cAMP-dependent protein kinase catalytic subunit alpha Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.79 71.4 41.3 Yes Yes
2 empty 1.96 68.6 29.7 No No
3 empty 2.3 63.1 28.8 No No
4 empty 2.46 58 34.9 No No
5 empty 2.6 76.9 11.6 No No
6 empty 2.47 64 20.5 No No
7 empty 2.03 66 16.8 No No
8 empty 2.03 66.2 13.8 No No
9 empty 1.8 63 12.4 No No
10 empty 2.18 66.5 15.7 No No
2UW3_A cAMP-dependent protein kinase catalytic subunit alpha Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.81 73.1 35.5 Yes Yes
2 empty 2.19 65.8 26.5 No No
3 empty 2.11 67.7 27.2 No No
4 empty 2.72 74 18.2 No No
5 empty 1.98 64.6 18.1 No No
6 empty 1.62 76.4 14.7 No No
7 empty 2.03 67.6 18.3 No No
8 empty 2.02 64.9 20.7 No No
9 empty 1.92 61.7 15.1 No No
10 empty 2.51 64.1 19.7 No No
2GNH_A cAMP-dependent protein kinase catalytic subunit alpha Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.91 68.5 45.7 Yes Yes
2 empty 2.38 68.9 19.6 No No
3 empty 2.04 63.8 17.6 No No
4 empty 2.04 67.4 13.4 No No
5 empty 2.03 71.2 14.6 No No
6 empty 1.97 63 16.4 No No
7 empty 1.85 61 14.4 No No
8 empty 2.01 69.8 11.1 No No
9 empty 2.07 51.1 12 No No
10 empty 2.29 64.6 14.4 No No
1Q8U_A cAMP-dependent protein kinase catalytic subunit alpha Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.92 71.1 34.7 Yes Yes
2 empty 2.19 67.6 23.3 No No
3 empty 2.59 68.5 19.2 No No
4 bound 1.89 65.6 17.5 No No
5 empty 2.36 59 18.6 No No
6 empty 2.09 65.6 18.4 No No
7 empty 2.25 59.8 17 No No
8 empty 1.96 59.7 19.9 No No
9 empty 1.82 63.9 14.8 No No
10 empty 2.26 54.2 19.5 No No
2UZU_E cAMP-dependent protein kinase catalytic subunit alpha Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.85 72.8 36.9 Yes Yes
2 empty 2.33 73.2 21.4 No No
3 empty 2.4 67.6 20.8 No No
4 empty 2.04 68.3 16.8 No No
5 empty 2.45 58.8 27.1 No No
6 empty 2.19 68.9 15.7 No No
7 empty 2.54 62.6 25.6 No No
8 empty 1.82 61.4 16.1 No No
9 empty 2.18 71.2 13.7 No No
10 empty 1.58 81.5 14 No No
1STC_E cAMP-dependent protein kinase catalytic subunit alpha Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.68 74.2 46.3 Yes Yes
2 empty 2.02 65.6 29.6 No No
3 empty 2.14 68.8 16.1 No No
4 empty 2.15 71.9 13.5 No No
5 empty 2.09 62.5 14.1 No No
6 empty 2.25 62.2 13.6 No No
7 empty 2.03 67 12.3 No No
8 empty 1.7 63.5 12.8 No No
9 empty 2.25 62.9 16.6 No No
10 empty 2.16 67.8 17.3 No No
1XHA_A cAMP-dependent protein kinase catalytic subunit alpha Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.94 76.8 32.5 Yes Yes
2 empty 2.22 64.4 32.5 No No
3 empty 2.45 68.7 24.4 No No
4 empty 2.58 72 18.8 No No
5 empty 2.41 64.5 25.3 No No
6 empty 1.89 63.5 14.2 No No
7 empty 1.91 62.5 15.1 No No
8 empty 1.75 83.6 14.7 No No
9 empty 2.22 75 12.9 No No
10 empty 2.29 57.6 17.8 No No

Domain-based assessment (last updated 30/07/2012)


Domains assessed71
Domains assessed as druggable using the strict criteria65
Domains assessed as druggable using the relaxed criteria70

PDB (Domain) Protein Name Domain Resolution Ligands Druggable Relaxed Druggable Strict
1CDK_B (41621) cAMP-dependent protein kinase catalytic subunit alpha Protein kinase-like (PK-like), Protein kinase-like (PK-like), Protein kinases catalytic subunit 2Å Yes Yes
1CDK_A (41620) cAMP-dependent protein kinase catalytic subunit alpha Protein kinase-like (PK-like), Protein kinase-like (PK-like), Protein kinases catalytic subunit 2Å Yes Yes
1CMK_E (41623) cAMP-dependent protein kinase catalytic subunit alpha Protein kinase-like (PK-like), Protein kinase-like (PK-like), Protein kinases catalytic subunit 2.9Å Yes Yes
1Q24_A (95618) cAMP-dependent protein kinase catalytic subunit alpha Protein kinase-like (PK-like), Protein kinase-like (PK-like), Protein kinases catalytic subunit 2.6Å Yes Yes
1Q61_A (95955) cAMP-dependent protein kinase catalytic subunit alpha Protein kinase-like (PK-like), Protein kinase-like (PK-like), Protein kinases catalytic subunit 2.1Å Yes No
1Q62_A (95956) cAMP-dependent protein kinase catalytic subunit alpha Protein kinase-like (PK-like), Protein kinase-like (PK-like), Protein kinases catalytic subunit 2.3Å Yes No
1Q8T_A (96229) cAMP-dependent protein kinase catalytic subunit alpha Protein kinase-like (PK-like), Protein kinase-like (PK-like), Protein kinases catalytic subunit 2Å Yes Yes
1Q8U_A (96230) cAMP-dependent protein kinase catalytic subunit alpha Protein kinase-like (PK-like), Protein kinase-like (PK-like), Protein kinases catalytic subunit 1.9Å Yes Yes
1Q8W_A (96233) cAMP-dependent protein kinase catalytic subunit alpha Protein kinase-like (PK-like), Protein kinase-like (PK-like), Protein kinases catalytic subunit 2.2Å Yes Yes
1SMH_A (105757) cAMP-dependent protein kinase catalytic subunit alpha Protein kinase-like (PK-like), Protein kinase-like (PK-like), Protein kinases catalytic subunit 2.04Å Yes Yes
1STC_E (41627) cAMP-dependent protein kinase catalytic subunit alpha Protein kinase-like (PK-like), Protein kinase-like (PK-like), Protein kinases catalytic subunit 2.3Å Yes Yes
1SVE_A (119060) cAMP-dependent protein kinase catalytic subunit alpha Protein kinase-like (PK-like), Protein kinase-like (PK-like), Protein kinases catalytic subunit 2.49Å Yes Yes
1SVG_A (119061) cAMP-dependent protein kinase catalytic subunit alpha Protein kinase-like (PK-like), Protein kinase-like (PK-like), Protein kinases catalytic subunit 2Å Yes Yes
1SVH_A (119062) cAMP-dependent protein kinase catalytic subunit alpha Protein kinase-like (PK-like), Protein kinase-like (PK-like), Protein kinases catalytic subunit 2.3Å Yes Yes
1SZM_A (106160) cAMP-dependent protein kinase catalytic subunit alpha Protein kinase-like (PK-like), Protein kinase-like (PK-like), Protein kinases catalytic subunit 2.5Å Yes Yes
1SZM_B (106161) cAMP-dependent protein kinase catalytic subunit alpha Protein kinase-like (PK-like), Protein kinase-like (PK-like), Protein kinases catalytic subunit 2.5Å Yes Yes
1VEB_A (120017) cAMP-dependent protein kinase catalytic subunit alpha Protein kinase-like (PK-like), Protein kinase-like (PK-like), Protein kinases catalytic subunit 2.89Å Yes Yes
1XH4_A (121995) cAMP-dependent protein kinase catalytic subunit alpha Protein kinase-like (PK-like), Protein kinase-like (PK-like), Protein kinases catalytic subunit 2.45Å Yes Yes
1XH5_A (121996) cAMP-dependent protein kinase catalytic subunit alpha Protein kinase-like (PK-like), Protein kinase-like (PK-like), Protein kinases catalytic subunit 2.05Å Yes Yes
1XH6_A (121997) cAMP-dependent protein kinase catalytic subunit alpha Protein kinase-like (PK-like), Protein kinase-like (PK-like), Protein kinases catalytic subunit 1.9Å Yes Yes
1XH7_A (121998) cAMP-dependent protein kinase catalytic subunit alpha Protein kinase-like (PK-like), Protein kinase-like (PK-like), Protein kinases catalytic subunit 2.47Å Yes Yes
1XH8_A (121999) cAMP-dependent protein kinase catalytic subunit alpha Protein kinase-like (PK-like), Protein kinase-like (PK-like), Protein kinases catalytic subunit 1.6Å Yes Yes
1XH9_A (3020546) cAMP-dependent protein kinase catalytic subunit alpha Protein kinase-like (PK-like), Protein kinase-like (PK-like), UNMATCHED 1.64Å Yes Yes
1XHA_A (122000) cAMP-dependent protein kinase catalytic subunit alpha Protein kinase-like (PK-like), Protein kinase-like (PK-like), Protein kinases catalytic subunit 2.46Å Yes Yes
1YDR_E (41624) cAMP-dependent protein kinase catalytic subunit alpha Protein kinase-like (PK-like), Protein kinase-like (PK-like), Protein kinases catalytic subunit 2.2Å Yes Yes
1YDS_E (41625) cAMP-dependent protein kinase catalytic subunit alpha Protein kinase-like (PK-like), Protein kinase-like (PK-like), Protein kinases catalytic subunit 2.2Å Yes Yes
1YDT_E (41626) cAMP-dependent protein kinase catalytic subunit alpha Protein kinase-like (PK-like), Protein kinase-like (PK-like), Protein kinases catalytic subunit 2.3Å Yes Yes
2C1A_A (129628) cAMP-dependent protein kinase catalytic subunit alpha Protein kinase-like (PK-like), Protein kinase-like (PK-like), Protein kinases catalytic subunit 1.95Å Yes Yes
2C1B_A (129629) cAMP-dependent protein kinase catalytic subunit alpha Protein kinase-like (PK-like), Protein kinase-like (PK-like), Protein kinases catalytic subunit 2Å Yes Yes
2F7E_E (133087) cAMP-dependent protein kinase catalytic subunit alpha Protein kinase-like (PK-like), Protein kinase-like (PK-like), Protein kinases catalytic subunit 2Å Yes Yes
2F7X_E (133109) cAMP-dependent protein kinase catalytic subunit alpha Protein kinase-like (PK-like), Protein kinase-like (PK-like), Protein kinases catalytic subunit 1.9Å Yes Yes
2F7Z_E (133113) cAMP-dependent protein kinase catalytic subunit alpha Protein kinase-like (PK-like), Protein kinase-like (PK-like), Protein kinases catalytic subunit 3Å Yes Yes
2GFC_A (135093) cAMP-dependent protein kinase catalytic subunit alpha Protein kinase-like (PK-like), Protein kinase-like (PK-like), Protein kinases catalytic subunit 1.642Å No No
2GNF_A (3100234) cAMP-dependent protein kinase catalytic subunit alpha Protein kinase-like (PK-like), Protein kinase-like (PK-like), UNMATCHED 2.16Å Yes Yes
2GNG_A (3100236) cAMP-dependent protein kinase catalytic subunit alpha Protein kinase-like (PK-like), Protein kinase-like (PK-like), UNMATCHED 1.75Å Yes Yes
2GNH_A (3100238) cAMP-dependent protein kinase catalytic subunit alpha Protein kinase-like (PK-like), Protein kinase-like (PK-like), UNMATCHED 1.75Å Yes Yes
2GNI_A (3100240) cAMP-dependent protein kinase catalytic subunit alpha Protein kinase-like (PK-like), Protein kinase-like (PK-like), UNMATCHED 2.27Å Yes Yes
2GNJ_A (3100242) cAMP-dependent protein kinase catalytic subunit alpha Protein kinase-like (PK-like), Protein kinase-like (PK-like), UNMATCHED 2.2Å Yes No
2GNL_A (3100244) cAMP-dependent protein kinase catalytic subunit alpha Protein kinase-like (PK-like), Protein kinase-like (PK-like), UNMATCHED 2.598Å Yes Yes
2JDS_A (138277) cAMP-dependent protein kinase catalytic subunit alpha Protein kinase-like (PK-like), Protein kinase-like (PK-like), Protein kinases catalytic subunit 2Å Yes Yes
2JDT_A (3130400) cAMP-dependent protein kinase catalytic subunit alpha Protein kinase-like (PK-like), Protein kinase-like (PK-like), UNMATCHED 2.15Å Yes Yes
2JDV_A (3130403) cAMP-dependent protein kinase catalytic subunit alpha Protein kinase-like (PK-like), Protein kinase-like (PK-like), UNMATCHED 2.08Å Yes No
2OH0_E (139069) cAMP-dependent protein kinase catalytic subunit alpha Protein kinase-like (PK-like), Protein kinase-like (PK-like), Protein kinases catalytic subunit 2.2Å Yes Yes
2OJF_E (139113) cAMP-dependent protein kinase catalytic subunit alpha Protein kinase-like (PK-like), Protein kinase-like (PK-like), Protein kinases catalytic subunit 2.05Å Yes Yes
2UVX_A (3210149) cAMP-dependent protein kinase catalytic subunit alpha Protein kinase-like (PK-like), Protein kinase-like (PK-like), UNMATCHED 2Å Yes Yes
2UVY_A (3210151) cAMP-dependent protein kinase catalytic subunit alpha Protein kinase-like (PK-like), Protein kinase-like (PK-like), UNMATCHED 1.95Å Yes No
2UVZ_A (3210153) cAMP-dependent protein kinase catalytic subunit alpha Protein kinase-like (PK-like), Protein kinase-like (PK-like), UNMATCHED 1.94Å Yes Yes
2UW0_A (3210155) cAMP-dependent protein kinase catalytic subunit alpha Protein kinase-like (PK-like), Protein kinase-like (PK-like), UNMATCHED 2Å Yes Yes
2UW3_A (3210159) cAMP-dependent protein kinase catalytic subunit alpha Protein kinase-like (PK-like), Protein kinase-like (PK-like), UNMATCHED 2.19Å Yes Yes
2UW4_A (3210161) cAMP-dependent protein kinase catalytic subunit alpha Protein kinase-like (PK-like), Protein kinase-like (PK-like), UNMATCHED 2Å Yes Yes
2UW5_A (3210163) cAMP-dependent protein kinase catalytic subunit alpha Protein kinase-like (PK-like), Protein kinase-like (PK-like), UNMATCHED 2.14Å Yes Yes
2UW6_A (3210165) cAMP-dependent protein kinase catalytic subunit alpha Protein kinase-like (PK-like), Protein kinase-like (PK-like), UNMATCHED 2.23Å Yes Yes
2UW7_A (3210167) cAMP-dependent protein kinase catalytic subunit alpha Protein kinase-like (PK-like), Protein kinase-like (PK-like), UNMATCHED 2.1Å Yes Yes
2UW8_A (3210169) cAMP-dependent protein kinase catalytic subunit alpha Protein kinase-like (PK-like), Protein kinase-like (PK-like), UNMATCHED 2Å Yes Yes
2UZT_A (3210286) cAMP-dependent protein kinase catalytic subunit alpha Protein kinase-like (PK-like), Protein kinase-like (PK-like), UNMATCHED 2.1Å Yes Yes
2UZU_E (3210288) cAMP-dependent protein kinase catalytic subunit alpha Protein kinase-like (PK-like), Protein kinase-like (PK-like), UNMATCHED 2.4Å Yes Yes
2UZV_A (3210291) cAMP-dependent protein kinase catalytic subunit alpha Protein kinase-like (PK-like), Protein kinase-like (PK-like), UNMATCHED 2.5Å Yes Yes
2UZW_E (3210292) cAMP-dependent protein kinase catalytic subunit alpha Protein kinase-like (PK-like), Protein kinase-like (PK-like), UNMATCHED 2.2Å Yes Yes
2VNW_A (3220400) cAMP-dependent protein kinase catalytic subunit alpha Protein kinase-like (PK-like), Protein kinase-like (PK-like), UNMATCHED 2.09Å Yes Yes
2VNY_A (3220403) cAMP-dependent protein kinase catalytic subunit alpha Protein kinase-like (PK-like), Protein kinase-like (PK-like), UNMATCHED 1.96Å Yes Yes
2VO0_A (3220406) cAMP-dependent protein kinase catalytic subunit alpha Protein kinase-like (PK-like), Protein kinase-like (PK-like), UNMATCHED 1.94Å Yes Yes
2VO3_A (3220409) cAMP-dependent protein kinase catalytic subunit alpha Protein kinase-like (PK-like), Protein kinase-like (PK-like), UNMATCHED 1.98Å Yes Yes
2VO6_A (3220413) cAMP-dependent protein kinase catalytic subunit alpha Protein kinase-like (PK-like), Protein kinase-like (PK-like), UNMATCHED 1.97Å Yes Yes
2VO7_A (153360) cAMP-dependent protein kinase catalytic subunit alpha Protein kinase-like (PK-like), Protein kinase-like (PK-like), Protein kinases catalytic subunit 1.98Å Yes Yes
3AG9_A (3310144) cAMP-dependent protein kinase catalytic subunit alpha Protein kinase-like (PK-like), Protein kinase-like (PK-like), UNMATCHED 2Å Yes Yes
3AG9_A (4084922) cAMP-dependent protein kinase catalytic subunit alpha Protein kinase-like (PK-like), Protein kinase-like (PK-like), Protein kinases catalytic subunit (Homo Multimer) 2Å Yes Yes
3AG9_B (4084922) cAMP-dependent protein kinase catalytic subunit alpha Protein kinase-like (PK-like), Protein kinase-like (PK-like), Protein kinases catalytic subunit (Homo Multimer) 2Å Yes Yes
3BWJ_A (3320806) cAMP-dependent protein kinase catalytic subunit alpha Protein kinase-like (PK-like), Protein kinase-like (PK-like), UNMATCHED 2.3Å Yes Yes
3DND_A (3360724) cAMP-dependent protein kinase catalytic subunit alpha Protein kinase-like (PK-like), Protein kinase-like (PK-like), UNMATCHED 2.26Å Yes Yes
3DNE_A (3360726) cAMP-dependent protein kinase catalytic subunit alpha Protein kinase-like (PK-like), Protein kinase-like (PK-like), UNMATCHED 2Å Yes Yes
3E8C_A (3370954) cAMP-dependent protein kinase catalytic subunit alpha Protein kinase-like (PK-like), Protein kinase-like (PK-like), UNMATCHED 2.2Å Yes Yes
3E8E_A (3370957) cAMP-dependent protein kinase catalytic subunit alpha Protein kinase-like (PK-like), Protein kinase-like (PK-like), UNMATCHED 1.72Å Yes Yes
Ligand-based Druggability Score:
Ligand-based Druggability Score Percentile: %
Ligand-based Druggability Help: Help




		
This protein has no network-based druggability score