Molecular Target Synopsis
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PRKAR1A (P00514) - Druggability - Molecular Target Synopsis

Chain-based assessment (last updated 10/09/2019)
Domain-based assessment (last updated 30/07/2012)


Structural Druggability Help: Help

Chain-based assessment (last updated 10/09/2019)


Chains assessed35
Chains with at least one site assessed as druggable using the strict criteria10
Chains with at least one site assessed as druggable using the relaxed criteria25


		
PDB Chain Protein Name Druggable Relaxed Druggable Strict Details
3IM4_B cAMP-dependent protein kinase type I-alpha regulatory subunit Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.31 60.8 24.4 Yes No
2 empty 2.64 56.7 11.5 No No
3 empty 2.61 63.3 11.6 No No
4 empty 2.62 64 7.1 No No
5 empty 1.97 45.2 9.4 No No
6 empty .19 56.4 7.2 No No
7 empty 2.9 53.8 8.1 No No
8 empty 2.28 53.7 5.2 No No
9 empty 2.97 64.9 5.2 No No
1NE4_A cAMP-dependent protein kinase type I-alpha regulatory subunit Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.93 58.2 26 Yes No
2 bound 1.24 69.8 20.5 No No
3 bound 2.26 68.2 18.2 No No
4 empty 2.02 62.9 22.3 No No
5 empty 2.14 54.5 19.8 No No
6 empty 1.98 58.1 16.7 No No
7 empty 2.05 60.6 16 No No
8 bound 1.23 98.9 0 Yes No
9 empty 2.2 54.7 11 No No
10 empty 2.19 59.4 11.8 No No
4X6R_B cAMP-dependent protein kinase type I-alpha regulatory subunit Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.12 65.5 35.3 Yes No
2 bound 2.03 57.8 28.7 No No
3 empty 2.09 55.2 24.8 No No
4 empty 2.51 66 25 No No
5 bound 1.84 71.4 22.8 No No
6 bound 2.38 59.1 15.1 No No
7 empty 1.91 56.8 11.6 No No
8 empty 2.31 69 10.5 No No
9 empty 2.04 70.6 10.1 No No
10 empty 2.82 52.5 11.7 No No
2EZW_A cAMP-dependent protein kinase type I-alpha regulatory subunit No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.47 67.6 19.6 No No
2 empty 2.12 56.8 18.5 No No
3 empty 1.93 61.3 11.4 No No
4 empty 2.33 48.9 14 No No
5 empty .99 64 6.6 No No
6 empty .79 57.6 7.6 No No
7 empty 2.47 49.2 8.7 No No
8 empty 2.76 62 7.1 No No
9 empty 2.67 57.9 6.1 No No
10 empty 2.44 66.3 5.1 No No
3IIA_A cAMP-dependent protein kinase type I-alpha regulatory subunit No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.83 71.2 20.8 No No
2 empty 1.97 65 22.3 No No
3 empty 2.43 61.1 15.7 No No
4 empty 2.19 69 16.7 No No
5 empty 2.07 58.6 9.7 No No
6 empty 2.68 66.9 10 No No
7 empty 2.56 72.2 10 No No
8 empty 2.14 59.8 9.8 No No
9 empty 2.99 75.7 7.6 No No
10 empty 1.27 60.2 7.8 No No
6BYR_D cAMP-dependent protein kinase type I-alpha regulatory subunit Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.24 67.7 34.5 Yes Yes
2 empty 1.96 68.5 25.5 No No
3 empty 2.57 62.5 26.3 No No
4 empty 2 55.9 20.4 No No
5 empty 1.61 70.5 17.3 No No
6 empty 2.03 53.7 21.4 No No
7 empty 2.24 58.2 15.9 No No
8 empty 2.02 62 14.9 No No
9 empty 2.06 68.6 9.2 No No
10 empty 1.87 72.7 12.7 No No
6NO7_D cAMP-dependent protein kinase type I-alpha regulatory subunit Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.25 62.2 33.7 Yes No
2 empty 1.66 60.9 44.7 No No
3 empty 1.98 71.1 31.2 No No
4 empty 2.29 68.1 28.2 No No
5 empty 2 64.2 19.4 No No
6 empty 2.21 56 14.7 No No
7 empty 2.23 60.2 17.2 No No
8 empty 2.51 68.3 11.2 No No
9 empty 1.89 67.1 10.9 No No
10 empty 3.04 43.2 10.4 No No
6BYR_B cAMP-dependent protein kinase type I-alpha regulatory subunit Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.19 66.2 37.6 Yes Yes
2 empty 1.86 66.8 23.1 No No
3 empty 2.55 67.3 26.3 No No
4 empty 1.94 61.4 20.3 No No
5 empty 1.62 71.1 15.8 No No
6 empty 2.06 47.4 18.2 No No
7 empty 1.97 67.9 14.7 No No
8 empty 2.13 54.9 14.4 No No
9 empty 2.44 61.1 11 No No
10 empty 2.38 61.1 13.6 No No
3IM4_A cAMP-dependent protein kinase type I-alpha regulatory subunit No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.07 53.7 18.3 No No
2 empty 2.39 59.3 8.5 No No
3 empty .42 58.3 8.2 No No
4 empty 2.37 51.7 10 No No
5 empty 2.12 52.8 9.9 No No
6 empty 2.45 66.4 6.3 No No
7 empty 2.32 70.6 7.4 No No
8 empty 2.67 51.9 8.6 No No
9 empty 3.15 75.2 5.4 No No
10 empty 2.83 62.4 6.8 No No
6BYS_F cAMP-dependent protein kinase type I-alpha regulatory subunit Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.11 65.2 32.1 Yes No
2 empty 1.6 68.8 34.5 No No
3 empty 2.53 60.3 24 No No
4 empty 1.86 60.1 18.3 No No
5 empty 2.03 50.8 20.1 No No
6 empty 1.41 69.3 13.3 No No
7 empty .82 95.4 0 Yes No
8 empty 2.18 60.8 10.3 No No
9 empty 2.63 63.3 11.5 No No
10 empty .89 96.6 0 Yes No
6NO7_B cAMP-dependent protein kinase type I-alpha regulatory subunit Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.31 64.6 38.8 Yes No
2 empty 1.98 63.7 21.7 No No
3 empty 2.02 80.9 13.5 No No
4 empty 2.32 51.5 25.2 No No
5 empty 2.04 59 18.4 No No
6 empty 1.47 76.8 13.3 No No
7 empty 2.31 54.5 14.7 No No
8 empty 2.1 57.8 23.9 No No
9 empty 1.93 72.1 15.5 No No
10 empty 2.53 70.2 9 No No
5HVZ_A cAMP-dependent protein kinase type I-alpha regulatory subunit No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.24 58.1 21 No No
2 empty 2.63 57.6 11.8 No No
3 empty 2.49 56 12.3 No No
4 empty 2.09 57.9 8.8 No No
5 empty 1.82 57.1 8.8 No No
6 empty .08 65.1 7.6 No No
7 empty 3.15 38.8 6.8 No No
8 empty 2.84 64.4 5 No No
9 empty 2.88 61 6.2 No No
10 empty 2.84 65.2 4.5 No No
3PVB_B cAMP-dependent protein kinase type I-alpha regulatory subunit No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.24 52 23.2 No No
2 empty 2.02 58.6 14.7 No No
3 bound 1.62 69.5 15.4 No No
4 empty 2.51 62.6 20.4 No No
5 empty 2.1 60.6 13.8 No No
6 empty 2.55 64.3 13.2 No No
7 empty 1.66 68.6 9.2 No No
8 empty 2.36 65.5 8.4 No No
9 empty 2.21 42.7 10.6 No No
10 empty 2.34 60.7 10.9 No No
4MX3_B cAMP-dependent protein kinase type I-alpha regulatory subunit Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.92 67.6 40.7 Yes Yes
2 bound 2.07 77.7 27.4 No No
3 bound 1.63 74.4 20.5 No No
4 empty 2.27 58.2 17.8 No No
5 empty 2.15 69.5 20.7 No No
6 empty 1.66 60 19.1 No No
7 empty 2.19 71 8.8 No No
8 empty 2.44 65.2 12.5 No No
9 empty 1.99 55.1 16.9 No No
10 empty 2.58 65.7 10.5 No No
5HVZ_B cAMP-dependent protein kinase type I-alpha regulatory subunit No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.11 57.1 22.3 No No
2 empty 2.22 53.6 13.4 No No
3 empty .48 49.8 10.8 No No
4 empty 2.71 61.4 7.2 No No
5 empty 2.07 55.6 10.5 No No
6 empty 3.31 40 6.9 No No
7 empty 1.65 56.1 5.8 No No
8 empty 2.3 55.9 5.9 No No
9 empty 2 68.9 5.1 No No
1NE6_A cAMP-dependent protein kinase type I-alpha regulatory subunit Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.17 63.6 36.9 Yes No
2 bound 2 74 27.9 No No
3 bound 1.25 72.1 23.8 No No
4 empty 2.14 59.6 19.5 No No
5 empty 2.18 68 17.3 No No
6 empty 1.91 59.2 18.5 No No
7 empty 2.42 57.7 11.5 No No
8 empty 2.43 67.1 11.6 No No
9 empty 2.39 57.8 12.4 No No
10 empty 2.26 65.4 12.5 No No
4JV4_A cAMP-dependent protein kinase type I-alpha regulatory subunit Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2 70.7 37.9 Yes Yes
2 bound 1.91 71.9 25.6 No No
3 empty 2.28 61.3 19.2 No No
4 empty 1.94 60 16.9 No No
5 empty 2.04 59.2 17.7 No No
6 empty 2.16 61.5 17.3 No No
7 empty 2.08 61.1 14.5 No No
8 empty 2.22 67.5 21.2 No No
9 empty 2.17 73.5 11.7 No No
10 empty 2.52 69.8 8.6 No No
6BYS_H cAMP-dependent protein kinase type I-alpha regulatory subunit Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.42 61.3 27.1 Yes No
2 empty 2.16 67.3 26.7 No No
3 empty 1.74 71.4 24.9 No No
4 empty 1.9 63.3 28.1 No No
5 empty 1.91 57.4 27.4 No No
6 empty 2.47 64.8 17.2 No No
7 empty .8 95.5 0 Yes No
8 empty 2.2 63.2 10.2 No No
9 empty 2.59 62.7 12.3 No No
10 empty .46 98.6 0 Yes No
3FHI_B cAMP-dependent protein kinase type I-alpha regulatory subunit Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.3 62.3 27.5 Yes No
2 empty 2.25 63.7 18 No No
3 empty 1.66 71.6 17.7 No No
4 empty 2.14 64.6 17.2 No No
5 empty 2.15 44.8 15.8 No No
6 empty 2.52 65.2 9.4 No No
7 empty 2.54 68.7 9.8 No No
8 empty 1.92 66.9 7.4 No No
9 empty 2.72 67.3 7 No No
10 empty 2.57 61.5 8 No No
3PLQ_A cAMP-dependent protein kinase type I-alpha regulatory subunit No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.33 64.7 22 No No
2 empty 1.83 55.3 17.1 No No
3 bound 1.73 71.3 19.2 No No
4 empty 1.95 66.2 11.7 No No
5 empty 2.56 65.9 9.5 No No
6 empty 2.84 66.5 9.6 No No
7 empty 2.68 64.7 8.7 No No
8 empty 1.84 68.5 8.6 No No
9 empty 2.73 53.2 13.5 No No
10 empty 2.86 71.5 7.4 No No
1RGS_A cAMP-dependent protein kinase type I-alpha regulatory subunit Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2 65.1 24 Yes No
2 bound 2.1 65.3 21.5 No No
3 bound 1.72 70.1 20.9 No No
4 empty 2.06 60.6 23.2 No No
5 empty 1.98 63.7 19.5 No No
6 empty 1.93 62.8 14.3 No No
7 empty 1.69 60.7 17.9 No No
8 empty 2.39 53.7 13.9 No No
9 bound 1.04 95.1 0 Yes No
10 empty 2.28 59 10.9 No No
2EZW_B cAMP-dependent protein kinase type I-alpha regulatory subunit No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.31 69.3 16.9 No No
2 empty 2.11 58.7 16.5 No No
3 empty 1.9 56.2 10.8 No No
4 empty 2.31 51.8 12.4 No No
5 empty .78 64 10.4 No No
6 empty 1.08 66.9 7 No No
7 empty 2.34 50.9 7.1 No No
8 empty 2.91 50.5 7 No No
9 empty 2.76 55.8 7.5 No No
10 empty 2.6 57.1 4.8 No No
6BYS_D cAMP-dependent protein kinase type I-alpha regulatory subunit Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.1 64.2 33.4 Yes No
2 empty 1.7 65.9 34.4 No No
3 empty 2.46 61 24.1 No No
4 empty 1.88 61.6 14.3 No No
5 empty 2.4 50.9 17.2 No No
6 empty 1.41 71.4 13.5 No No
7 empty .37 95.4 0 Yes No
8 empty 2.21 65 11.7 No No
9 empty 2.58 62.3 10.8 No No
10 empty .83 99.3 0 Yes No
3IM3_A cAMP-dependent protein kinase type I-alpha regulatory subunit No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.01 59.4 16.6 No No
2 bound 2.27 56 16.9 No No
3 empty 2.45 56.3 12.8 No No
4 empty 2.24 54.6 12.8 No No
5 empty 1.71 58 8.4 No No
6 empty 2.59 50 9.1 No No
7 empty .34 57 9.3 No No
8 empty 2.73 70.5 6.5 No No
9 empty 2.87 62.3 7 No No
10 empty 2.63 61.2 6.4 No No
4MX3_A cAMP-dependent protein kinase type I-alpha regulatory subunit Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.8 66.8 46.7 Yes Yes
2 bound 2.25 71.9 33.3 No No
3 empty 2.08 67.4 19.7 No No
4 empty 2.28 69 16.1 No No
5 empty 2.16 69.6 12 No No
6 empty 1.91 45.8 16.9 No No
7 empty 1.6 51.5 12.8 No No
8 empty 2.18 56.1 14.3 No No
9 empty 2.44 68.8 11.8 No No
10 empty .24 99.6 0 Yes No
2QCS_B cAMP-dependent protein kinase type I-alpha regulatory subunit Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.31 69.1 25.7 Yes Yes
2 empty 2.27 61 24.9 No No
3 empty 2.07 54.3 24.5 No No
4 empty 1.75 43.9 18.9 No No
5 bound 1.41 73.4 12.9 No No
6 bound 2.27 56.7 13.2 No No
7 empty 1.96 62.7 14.1 No No
8 empty 1.41 70.1 12 No No
9 bound 2.35 59 16 No No
10 empty 2.2 60.6 10.4 No No
3PNA_A cAMP-dependent protein kinase type I-alpha regulatory subunit Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.08 65.4 23.6 No No
2 bound 1.57 73.1 14.4 Yes No
3 empty 1.91 69.9 15 No No
4 empty 2.64 68.8 13 No No
5 empty 2.58 64.6 15 No No
6 empty 2.13 63.4 8 No No
7 empty 2.1 51 10.6 No No
8 empty 2.54 69.6 9.2 No No
9 empty 2.41 67.1 8.7 No No
10 empty 2.4 61.2 9.8 No No
3PNA_B cAMP-dependent protein kinase type I-alpha regulatory subunit Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.7 69.7 27.1 Yes No
2 empty 2.1 60 21.2 No No
3 empty 2.25 56.2 19.4 No No
4 empty 2.35 62.1 14.7 No No
5 empty 2.36 70.1 9.1 No No
6 empty 1.73 63.4 9.9 No No
7 empty 2.92 68.4 8.6 No No
8 empty 3.13 54.7 9 No No
9 empty 2.59 61 8.3 No No
10 bound 2.01 72.7 7 No No
6NO7_H cAMP-dependent protein kinase type I-alpha regulatory subunit Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.12 66.3 27.7 Yes Yes
2 empty 1.93 68.4 26 No No
3 empty 2.31 62.1 27.5 No No
4 empty 2.01 62 23.3 No No
5 empty 1.76 60.5 15.7 No No
6 empty 2.24 54.4 16.5 No No
7 empty 1.54 74.3 12.3 No No
8 empty 2.08 46 15.8 No No
9 empty 2 68.3 15.3 No No
10 empty 2.04 71.4 10.2 No No
5JR7_B cAMP-dependent protein kinase type I-alpha regulatory subunit Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.31 64.9 32 Yes No
2 empty 1.64 64.2 27.4 No No
3 empty 2.1 72 17.5 No No
4 empty 2.29 56.5 18.9 No No
5 empty 1.91 66.3 22.2 No No
6 empty 2.06 59.4 17.3 No No
7 empty 2.01 63.1 12.9 No No
8 empty 1.96 69.7 11.3 No No
9 empty 2.36 61.7 13.8 No No
10 empty 2.35 68.8 16.4 No No
1RL3_A cAMP-dependent protein kinase type I-alpha regulatory subunit No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.83 63.5 23 No No
2 empty 2.11 60.1 26.9 No No
3 bound 1.44 69.7 28.1 No No
4 empty 1.74 56.2 22.8 No No
5 empty 1.98 60 21.5 No No
6 empty 2.01 66.2 15.7 No No
7 empty 2.21 58.3 16.2 No No
8 empty 2.49 53.4 11.9 No No
9 empty 2.17 61.9 11.3 No No
10 empty 2.26 54.4 12.1 No No
1RL3_B cAMP-dependent protein kinase type I-alpha regulatory subunit Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.08 69.3 39.5 Yes Yes
2 bound 1.91 69.3 26 No No
3 empty 1.77 58.9 15.9 No No
4 empty 2.13 65.7 16.4 No No
5 empty 2.55 53.9 14.8 No No
6 empty 2.16 59 16.8 No No
7 empty 1.66 61.3 12.7 No No
8 empty 2.31 66.9 12.9 No No
9 empty 2.75 72.9 10.8 No No
10 empty 2.63 62.8 11.9 No No
6NO7_F cAMP-dependent protein kinase type I-alpha regulatory subunit Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.4 66.3 32 Yes Yes
2 empty 1.95 67.7 27.6 No No
3 empty 2 59.9 18.9 No No
4 empty 2.37 63.5 25.1 No No
5 empty 2.03 61.5 16.2 No No
6 empty 1.59 70.4 14.3 No No
7 empty 2.16 53.3 18.6 No No
8 empty 2.18 52.5 13.9 No No
9 empty 2.04 68.6 13.9 No No
10 empty 2.03 69.7 9.7 No No
6BYS_B cAMP-dependent protein kinase type I-alpha regulatory subunit Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.73 68.1 34.1 Yes Yes
2 empty 2.07 67 25.7 No No
3 empty 1.88 62.4 27.7 No No
4 empty 2.45 61.2 24.4 No No
5 empty 1.91 62.3 15.9 No No
6 empty 2.21 45.8 15.2 No No
7 empty 1.46 69.9 17.3 No No
8 empty .97 95.3 0 Yes No
9 empty 2.22 61 14.3 No No
10 empty 2.6 62.6 10.8 No No
5JR7_D cAMP-dependent protein kinase type I-alpha regulatory subunit Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.27 64.8 38.7 Yes No
2 empty 2.23 56.7 20.7 No No
3 empty 1.69 70.2 17 No No
4 empty 1.88 62.9 14.5 No No
5 empty 1.71 70.1 16.1 No No
6 empty 1.98 59.8 14.7 No No
7 empty 1.74 81.9 15.1 No No
8 empty 2.43 68.9 15.1 No No
9 empty 1.81 68.5 15.4 No No
10 empty 2.18 58 14.1 No No

Domain-based assessment (last updated 30/07/2012)


Domains assessed21
Domains assessed as druggable using the strict criteria5
Domains assessed as druggable using the relaxed criteria14

PDB (Domain) Protein Name Domain Resolution Ligands Druggable Relaxed Druggable Strict
1NE4_A (91830) cAMP-dependent protein kinase type I-alpha regulatory subunit Double-stranded beta-helix, cAMP-binding domain-like, cAMP-binding domain 2.4Å Yes Yes
1NE4_A (91829) cAMP-dependent protein kinase type I-alpha regulatory subunit Double-stranded beta-helix, cAMP-binding domain-like, cAMP-binding domain 2.4Å Yes No
1NE6_A (91831) cAMP-dependent protein kinase type I-alpha regulatory subunit Double-stranded beta-helix, cAMP-binding domain-like, cAMP-binding domain 2.3Å Yes No
1NE6_A (91832) cAMP-dependent protein kinase type I-alpha regulatory subunit Double-stranded beta-helix, cAMP-binding domain-like, cAMP-binding domain 2.3Å Yes Yes
1RGS_A (28146) cAMP-dependent protein kinase type I-alpha regulatory subunit Double-stranded beta-helix, cAMP-binding domain-like, cAMP-binding domain 2.8Å Yes No
1RGS_A (28147) cAMP-dependent protein kinase type I-alpha regulatory subunit Double-stranded beta-helix, cAMP-binding domain-like, cAMP-binding domain 2.8Å Yes Yes
1RL3_B (104978) cAMP-dependent protein kinase type I-alpha regulatory subunit Double-stranded beta-helix, cAMP-binding domain-like, cAMP-binding domain 2.7Å Yes Yes
1RL3_B (104977) cAMP-dependent protein kinase type I-alpha regulatory subunit Double-stranded beta-helix, cAMP-binding domain-like, cAMP-binding domain 2.7Å Yes No
1RL3_A (104975) cAMP-dependent protein kinase type I-alpha regulatory subunit Double-stranded beta-helix, cAMP-binding domain-like, cAMP-binding domain 2.7Å Yes No
1RL3_A (104976) cAMP-dependent protein kinase type I-alpha regulatory subunit Double-stranded beta-helix, cAMP-binding domain-like, cAMP-binding domain 2.7Å Yes Yes
2EZW_A (132645) cAMP-dependent protein kinase type I-alpha regulatory subunit Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit, Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit, Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit No No
2EZW_B (132646) cAMP-dependent protein kinase type I-alpha regulatory subunit Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit, Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit, Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit No No
2EZW_A (4153014) cAMP-dependent protein kinase type I-alpha regulatory subunit UNMATCHED, UNMATCHED, UNMATCHED 2EZW HOMO Yes No
2EZW_B (4153014) cAMP-dependent protein kinase type I-alpha regulatory subunit UNMATCHED, UNMATCHED, UNMATCHED 2EZW HOMO Yes No
3FHI_B (3410068) cAMP-dependent protein kinase type I-alpha regulatory subunit Double-stranded beta-helix, cAMP-binding domain-like, UNMATCHED 2Å Yes No
3IIA_A (3470968) cAMP-dependent protein kinase type I-alpha regulatory subunit Double-stranded beta-helix, cAMP-binding domain-like, UNMATCHED 2.7Å No No
3IM3_A (3480116) cAMP-dependent protein kinase type I-alpha regulatory subunit Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit, Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit, UNMATCHED 2Å No No
3IM4_A (3480117) cAMP-dependent protein kinase type I-alpha regulatory subunit Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit, Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit, UNMATCHED 2.285Å No No
3PLQ_A (3670353) cAMP-dependent protein kinase type I-alpha regulatory subunit Double-stranded beta-helix, cAMP-binding domain-like, UNMATCHED 2.3Å No No
3PNA_A (3670424) cAMP-dependent protein kinase type I-alpha regulatory subunit Double-stranded beta-helix, cAMP-binding domain-like, UNMATCHED 1.5Å Yes No
3PNA_B (4247496) cAMP-dependent protein kinase type I-alpha regulatory subunit Double-stranded beta-helix, cAMP-binding domain-like, cAMP-binding domain (Homo Multimer) 1.5Å Yes No
3PNA_A (4247496) cAMP-dependent protein kinase type I-alpha regulatory subunit Double-stranded beta-helix, cAMP-binding domain-like, cAMP-binding domain (Homo Multimer) 1.5Å Yes No
3PVB_B (3670944) cAMP-dependent protein kinase type I-alpha regulatory subunit Double-stranded beta-helix, cAMP-binding domain-like, UNMATCHED 3.3Å No No
Ligand-based Druggability Score:
Ligand-based Druggability Score Percentile: %
Ligand-based Druggability Help: Help




		
This protein has no network-based druggability score