Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

SOD1 (P00441) - Overview - Molecular Target Synopsis

Protein


SOD1, Superoxide dismutase [Cu-Zn]
Enzyme Classification 1.15.1.1
UniProt P00441

Also Known as SODC_HUMAN, SOD1

Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Homodimer; non-disulfide linked. Homodimerization may take place via the ditryptophan cross-link at Trp-33. The pathogenic variants ALS1 Arg-38, Arg-47, Arg-86 and Ala-94 interact with RNF19A, whereas wild-type protein does not. The pathogenic variants ALS1 Arg-86 and Ala-94 interact with MARCH5, whereas wild-type protein does not.

6FON
ELONGATED CONFORMER OF THE HUMAN COPPER CHAPERONE FOR SOD1 COMPLEXED WITH HUMAN SOD1
RCSB/PDB
Inspect Structure
See all 3D Structures for SOD1

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
154ENSG00000142168ENST00000270142ENSP00000270142P00441-1, P60052-1
135ENSG00000142168ENST00000389995ENSP00000374645

Sub-cellular localization


Gene Copy Number Variation


In COSMIC - Cell Lines Project SOD1 has gain in 0 cell-lines, loss in 1 cell-lines and no signal in 1004 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: A498, RPMI_8226, 786_0

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: TK, NCI-H520, DV-90

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: NHLF, HSMM, HMEC

(see details)

3D Structures


For SOD1 there are:
109 structures (487 chains) solved
22 are solved in complex with at least one small molecule ligand
3 are solved with an approved drug

SOD1 is solved in complex with the approved drug(s):

MET/METHIONINE (2WZ5_A, 2WZ5_F),
CYS/CYSTEINE (4FF9_A),
LDP/DOPAMINE (4A7V_A).

(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


SOD1 has been screened with 69 compounds (112 bioactivities). (see details)