ALDH1A1 (P00352) - Overview - Molecular Target Synopsis

ALDH1A1, Retinal dehydrogenase 1 Enzyme Classification 1.2.1.- UniProt P00352 Also Known as AL1A1_HUMAN, ALDH1A1, ALDC, ALDH1, PUMB1 Can convert/oxidize retinaldehyde to retinoic acid. Binds free retinal and cellular retinol-binding protein-bound retinal (By similarity). May have a broader specificity and oxidize other aldehydes in vivo (PubMed:19296407, PubMed:26373694, PubMed:25450233). Homotetramer.

5TEI STRUCTURE OF HUMAN ALDH1A1 WITH INHIBITOR CM039 RCSB/PDB Inspect Structure See all 3D Structures for ALDH1A1

Protein Length	Ensembl Gene	Ensembl Transcript	Ensembl Protein	Uniprot Isoform
501	ENSG00000165092	ENST00000297785	ENSP00000297785	P00352-1
245	ENSG00000165092	ENST00000419959	ENSP00000388026
230	ENSG00000165092	ENST00000376939	ENSP00000366138
203	ENSG00000165092	ENST00000446946	ENSP00000401361

UniProt: ALDH1A1 is active in the following subcellular-locations: cytoplasm, cytosol. GO terms: ALDH1A1 is active in the following subcellular-locations: cytoplasm, cytosol, extracellular exosome.

UniProt GO terms

In COSMIC - Cell Lines Project ALDH1A1 has gain in 2 cell-lines, loss in 3 cell-lines and no signal in 1000 cell-lines. (see details)

In NCI60, the highest expressing cell lines are: A549, A498, NCI_H522

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: SNU-5, RERF-LC-MS, DMS 454

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: HSMM, A549, BJ

(see details)

ALDH1A1 was reported in the following RNAI studies:

Cell - Large Scale Profiling of Kinase Dependencies in Cancer Cell Lines, the highest RNAi cell lines are: . (see details)

For ALDH1A1 there are:
10 structures (17 chains) solved
9 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

ALDH1A1 has been screened with 96 compounds (136 bioactivities), 13 compounds have bioactivities that show binding affinity of <= 500nM (14 bioactivities). (see details)