Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

LDHA (P00338) - Overview - Molecular Target Synopsis

Protein


LDHA, L-lactate dehydrogenase A chain
Enzyme Classification 1.1.1.27
UniProt P00338

Also Known as LDHA_HUMAN, LDHA

Homotetramer.

6BB0
LACTATE DEHYDROGENASE IN COMPLEX WITH INHIBITOR (R)-3-((2- CHLOROPHENYL)THIO)-6-(3-((4-FLUOROPHENYL)AMINO)PHENYL)-4-HYDROXY-6- (THIOPHEN-3-YL)-5,6-DIHYDRO-2H-PYRAN-2-ONE
RCSB/PDB
Inspect Structure
See all 3D Structures for LDHA

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: LDHA is active in the following subcellular-locations: cytoplasm.
GO terms: LDHA is active in the following subcellular-locations: cytosol, extracellular exosome, membrane, nucleus.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project LDHA has gain in 1 cell-lines, loss in 2 cell-lines and no signal in 1002 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: SK_OV_3, RXF_393, M14

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: SNU-1, C32, C32TG

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: HMEC, NHLF, NHEK

(see details)

3D Structures


For LDHA there are:
31 structures (148 chains) solved
29 are solved in complex with at least one small molecule ligand
1 are solved with an approved drug

LDHA is solved in complex with the approved drug(s):

KAN/KANAMYCIN (4OKN_B).

(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


LDHA has been screened with 372 compounds (620 bioactivities), 64 compounds have bioactivities that show binding affinity of <= 500nM (79 bioactivities). (see details)