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ADH1B (P00325) - Druggability - Molecular Target Synopsis

Chain-based assessment (last updated 14/05/2019)
Domain-based assessment (last updated 30/07/2012)


Structural Druggability Help: Help

Chain-based assessment (last updated 14/05/2019)


Chains assessed18
Chains with at least one site assessed as druggable using the strict criteria18
Chains with at least one site assessed as druggable using the relaxed criteria18


		
PDB Chain Protein Name Druggable Relaxed Druggable Strict Details
1U3U_A Alcohol dehydrogenase 1B Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.58 71.5 52.9 Yes Yes
2 empty 1.93 67.7 20.5 No No
3 empty 2.17 77.7 17.4 No No
4 empty 1.9 62.5 21.9 No No
5 empty 1.93 62.1 13.8 No No
6 empty 2.15 63.3 9.8 No No
7 empty 2.26 62.9 9.7 No No
8 empty 2.25 71.5 12.7 No No
9 empty 2.14 58.4 10.5 No No
10 empty 2.18 64.2 15.1 No No
1HSZ_B Alcohol dehydrogenase 1B Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.57 71.2 46.6 Yes Yes
2 empty 2.14 69.5 27.2 No No
3 empty 2.13 61.2 14 No No
4 empty 2.15 63.2 14 No No
5 empty 2.27 63.8 10.8 No No
6 empty 1.88 55.3 11.6 No No
7 empty 2.07 58 14.3 No No
8 empty 2.28 63.6 10.9 No No
9 empty 2.34 63.6 10.6 No No
10 empty 2.15 60.5 15.2 No No
1HDY_B Alcohol dehydrogenase 1B Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.48 70.8 46.5 Yes Yes
2 empty 1.86 65.4 19.8 No No
3 empty 2.27 80.3 17.2 No No
4 empty 2.5 59 17.5 No No
5 empty 2.02 60.2 21.7 No No
6 empty 2.07 60.1 14.1 No No
7 empty 2.23 62.8 14.1 No No
8 empty 1.65 56.7 10.5 No No
9 empty 2.2 65.3 12.5 No No
10 empty 1.59 62.8 10.5 No No
1HDX_A Alcohol dehydrogenase 1B Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.7 71.5 47.4 Yes Yes
2 empty 1.95 67.2 20.1 No No
3 empty 2.2 75.2 19.8 No No
4 empty 1.93 60.9 12.8 No No
5 empty 2.17 67.1 18.7 No No
6 empty 1.96 64.5 17.9 No No
7 empty 2.32 64.6 10.5 No No
8 empty 1.69 61.8 12.9 No No
9 empty 1.78 56.8 11.7 No No
10 empty 2.08 66 11.9 No No
1U3V_B Alcohol dehydrogenase 1B Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.59 71.9 48.8 Yes Yes
2 empty 2.42 68.8 28.3 No No
3 empty 2.01 65.4 13.6 No No
4 empty 2.3 63.6 19.9 No No
5 empty 1.89 56.5 19.3 No No
6 empty 1.93 71.5 11.8 No No
7 empty 2.04 63.1 16.8 No No
8 empty 2.36 63.7 15.1 No No
9 empty 2.19 59.6 12 No No
10 empty 2.07 61.3 14.3 No No
1HDZ_A Alcohol dehydrogenase 1B Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.54 69 51.1 Yes Yes
2 empty 1.8 68.7 17.7 No No
3 empty 2.08 72.5 17.5 No No
4 empty 2.3 66.9 15.5 No No
5 empty 2.19 61.6 10.5 No No
6 empty 1.86 62.9 16 No No
7 empty 2.19 62.4 11.4 No No
8 empty 1.87 60.3 11.1 No No
9 empty 1.83 53.4 12.5 No No
10 empty 2.23 68.5 7.9 No No
1HDX_B Alcohol dehydrogenase 1B Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.62 74.1 46 Yes Yes
2 empty 1.83 63.5 24.5 No No
3 empty 1.98 63.2 26.2 No No
4 empty 1.85 61.2 17.9 No No
5 empty 2.16 78.1 18.4 No No
6 empty 1.98 58.6 13.4 No No
7 empty 2.18 58.6 13.9 No No
8 empty 2.26 65 11.9 No No
9 empty 2.01 60.3 13.2 No No
10 empty 2.24 64.2 12.7 No No
1DEH_A Alcohol dehydrogenase 1B Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.51 74.4 45 Yes Yes
2 empty 2.17 70.7 25.6 No No
3 empty 2.09 59.3 21.4 No No
4 empty 1.9 60.2 12.8 No No
5 empty 2.18 67.1 18 No No
6 empty 2.01 63.3 11.8 No No
7 empty 2.18 61.7 10.2 No No
8 empty 2.1 64.5 11.3 No No
9 empty 1.88 62.4 10.6 No No
10 empty 2.1 61.3 16.7 No No
1HTB_A Alcohol dehydrogenase 1B Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.52 71.1 49.8 Yes Yes
2 empty 2.05 68.4 23 No No
3 empty 2.12 76.6 18.6 No No
4 empty 2.17 62.8 13.8 No No
5 empty 1.93 67 10.5 No No
6 empty 2.36 64.1 10.5 No No
7 empty 1.82 64.1 15.9 No No
8 empty 1.88 60.5 12.9 No No
9 empty 1.88 58.1 11 No No
10 empty 1.97 64.2 12.5 No No
3HUD_A Alcohol dehydrogenase 1B Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.58 72 52.1 Yes Yes
2 empty 2.02 65.4 33.2 No No
3 empty 2 61 21.2 No No
4 empty 2.32 76.7 19.3 No No
5 empty 1.83 80.1 14.3 No No
6 empty 1.78 57.3 13.3 No No
7 empty 2 59.4 13.9 No No
8 empty 1.92 60.6 10.6 No No
9 empty 1.91 62.3 16.1 No No
10 empty 2.33 57.6 15.8 No No
1HDY_A Alcohol dehydrogenase 1B Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.47 70.9 51.3 Yes Yes
2 empty 1.8 65.1 19.7 No No
3 empty 2.27 77.7 18.5 No No
4 empty 2.09 59 14.2 No No
5 empty 1.93 61.3 15.9 No No
6 empty 2.35 60.8 11 No No
7 empty 2.21 63.8 14.2 No No
8 empty 1.79 59.7 10.8 No No
9 empty 1.97 62.1 14.6 No No
10 empty 1.96 56.1 13.7 No No
1U3U_B Alcohol dehydrogenase 1B Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.55 70.5 55.1 Yes Yes
2 empty 1.96 70.3 13.7 No No
3 empty 2.09 61.5 12.9 No No
4 empty 2.18 63.7 13.9 No No
5 empty 1.84 58.6 11.4 No No
6 empty 2.18 64.6 15 No No
7 empty 1.97 57.7 13.4 No No
8 empty 2.17 61.3 11.6 No No
9 empty 2.3 58.4 11.8 No No
10 empty 2.23 68.4 9 No No
1U3V_A Alcohol dehydrogenase 1B Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.49 72.6 45.5 Yes Yes
2 empty 1.91 67.9 20.3 No No
3 empty 2.2 78 17.2 No No
4 empty 1.99 61.7 13.1 No No
5 empty 2.33 60.4 14.1 No No
6 empty 2.3 63.4 18.8 No No
7 empty 1.8 62.3 11.8 No No
8 empty 2.16 62.6 10.8 No No
9 empty 2.26 72.8 8.7 No No
10 empty 2.1 59.5 15 No No
1HTB_B Alcohol dehydrogenase 1B Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.49 72.9 45 Yes Yes
2 empty 1.77 61.8 20.2 No No
3 empty 2.25 77.7 16.9 No No
4 empty 1.77 56.2 10.9 No No
5 empty 2.27 64.8 12.6 No No
6 empty 2.25 66.3 11.9 No No
7 empty 2.12 70.7 8.6 No No
8 empty 2.28 61.3 12.5 No No
9 empty 2.09 56.2 13.5 No No
10 empty 2.1 69.4 9.5 No No
1HDZ_B Alcohol dehydrogenase 1B Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.53 72.4 45.4 Yes Yes
2 empty 2.03 62.2 30.6 No No
3 empty 2.04 62.4 22.7 No No
4 empty 2.15 76.4 17.2 No No
5 empty 1.89 57 15.4 No No
6 empty 2.21 61 12.1 No No
7 empty 2.13 60.7 13.3 No No
8 empty 2.32 57.7 18.5 No No
9 empty 2.16 62 13.7 No No
10 empty 1.91 60.5 14.7 No No
3HUD_B Alcohol dehydrogenase 1B Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.63 73.3 46.2 Yes Yes
2 empty 2.13 69.1 27.8 No No
3 empty 1.92 60.8 24.2 No No
4 empty 2.03 62.5 25 No No
5 empty 1.95 61.1 13.9 No No
6 empty 1.85 60.8 16.9 No No
7 empty 2.23 66 12.4 No No
8 empty 2.32 63.5 12.2 No No
9 empty 2.06 64.4 15.5 No No
10 empty 1.99 62.5 14.9 No No
1DEH_B Alcohol dehydrogenase 1B Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.55 70.7 48 Yes Yes
2 empty 1.8 62 20 No No
3 empty 2.14 76.5 17.3 No No
4 empty 1.86 60.7 17.5 No No
5 empty 1.98 56.3 13.5 No No
6 empty 2.5 66.1 17.4 No No
7 empty 2.35 63.7 12.1 No No
8 empty 1.87 63.1 11.5 No No
9 empty 2.1 59.2 16.7 No No
10 empty 2.17 57.2 16.4 No No
1HSZ_A Alcohol dehydrogenase 1B Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.55 71.6 50.4 Yes Yes
2 empty 2.16 67.4 28.4 No No
3 empty 2.28 76.4 18.1 No No
4 empty 1.81 58.7 12.6 No No
5 empty 2.3 63.9 13.7 No No
6 empty 2.28 63.7 11 No No
7 empty 2.02 52.6 11.2 No No
8 empty 2.19 61.5 14.1 No No
9 empty 2.46 64.4 11.1 No No
10 empty 2.27 70.2 9.4 No No

Domain-based assessment (last updated 30/07/2012)


Domains assessed45
Domains assessed as druggable using the strict criteria15
Domains assessed as druggable using the relaxed criteria44

PDB (Domain) Protein Name Domain Resolution Ligands Druggable Relaxed Druggable Strict
1DEH_B (24714) Alcohol dehydrogenase 1B GroES-like, GroES-like, Alcohol dehydrogenase-like N-terminal domain 2.19Å Yes No
1DEH_A (4038204) Alcohol dehydrogenase 1B NAD(P)-binding Rossmann-fold domains, NAD(P)-binding Rossmann-fold domains, Alcohol dehydrogenase-like C-terminal domain (Homo Multimer) 2.19Å Yes Yes
1DEH_B (4038204) Alcohol dehydrogenase 1B NAD(P)-binding Rossmann-fold domains, NAD(P)-binding Rossmann-fold domains, Alcohol dehydrogenase-like C-terminal domain (Homo Multimer) 2.19Å Yes Yes
1DEH_A (24713) Alcohol dehydrogenase 1B GroES-like, GroES-like, Alcohol dehydrogenase-like N-terminal domain 2.19Å Yes Yes
1DEH_A (24713) Alcohol dehydrogenase 1B GroES-like, GroES-like, Alcohol dehydrogenase-like N-terminal domain 2.19Å Yes Yes
1DEH_B (29730) Alcohol dehydrogenase 1B NAD(P)-binding Rossmann-fold domains, NAD(P)-binding Rossmann-fold domains, Alcohol dehydrogenase-like C-terminal domain 2.19Å Yes No
1DEH_A (29729) Alcohol dehydrogenase 1B NAD(P)-binding Rossmann-fold domains, NAD(P)-binding Rossmann-fold domains, Alcohol dehydrogenase-like C-terminal domain 2.19Å Yes No
1DEH_B (24714) Alcohol dehydrogenase 1B GroES-like, GroES-like, Alcohol dehydrogenase-like N-terminal domain 2.19Å Yes No
1HDX_B (4076626) Alcohol dehydrogenase 1B NAD(P)-binding Rossmann-fold domains, NAD(P)-binding Rossmann-fold domains, Alcohol dehydrogenase-like C-terminal domain (Homo Multimer) 2.5Å Yes Yes
1HDX_B (29734) Alcohol dehydrogenase 1B NAD(P)-binding Rossmann-fold domains, NAD(P)-binding Rossmann-fold domains, Alcohol dehydrogenase-like C-terminal domain 2.5Å Yes No
1HDX_A (29733) Alcohol dehydrogenase 1B NAD(P)-binding Rossmann-fold domains, NAD(P)-binding Rossmann-fold domains, Alcohol dehydrogenase-like C-terminal domain 2.5Å No No
1HDX_A (4076626) Alcohol dehydrogenase 1B NAD(P)-binding Rossmann-fold domains, NAD(P)-binding Rossmann-fold domains, Alcohol dehydrogenase-like C-terminal domain (Homo Multimer) 2.5Å Yes Yes
1HDX_B (24718) Alcohol dehydrogenase 1B GroES-like, GroES-like, Alcohol dehydrogenase-like N-terminal domain 2.5Å Yes No
1HDX_A (24717) Alcohol dehydrogenase 1B GroES-like, GroES-like, Alcohol dehydrogenase-like N-terminal domain 2.5Å Yes No
1HDX_A (24717) Alcohol dehydrogenase 1B GroES-like, GroES-like, Alcohol dehydrogenase-like N-terminal domain 2.5Å Yes No
1HDX_B (24718) Alcohol dehydrogenase 1B GroES-like, GroES-like, Alcohol dehydrogenase-like N-terminal domain 2.5Å Yes No
1HDY_A (24723) Alcohol dehydrogenase 1B GroES-like, GroES-like, Alcohol dehydrogenase-like N-terminal domain 2.5Å Yes No
1HDY_A (24723) Alcohol dehydrogenase 1B GroES-like, GroES-like, Alcohol dehydrogenase-like N-terminal domain 2.5Å Yes No
1HDY_B (24724) Alcohol dehydrogenase 1B GroES-like, GroES-like, Alcohol dehydrogenase-like N-terminal domain 2.5Å Yes No
1HDY_B (24724) Alcohol dehydrogenase 1B GroES-like, GroES-like, Alcohol dehydrogenase-like N-terminal domain 2.5Å Yes No
1HDY_A (29739) Alcohol dehydrogenase 1B NAD(P)-binding Rossmann-fold domains, NAD(P)-binding Rossmann-fold domains, Alcohol dehydrogenase-like C-terminal domain 2.5Å Yes No
1HDY_B (29740) Alcohol dehydrogenase 1B NAD(P)-binding Rossmann-fold domains, NAD(P)-binding Rossmann-fold domains, Alcohol dehydrogenase-like C-terminal domain 2.5Å Yes No
1HDY_B (4166191) Alcohol dehydrogenase 1B NAD(P)-binding Rossmann-fold domains, NAD(P)-binding Rossmann-fold domains, Alcohol dehydrogenase-like C-terminal domain (Homo Multimer) 2.5Å Yes Yes
1HDY_A (4166191) Alcohol dehydrogenase 1B NAD(P)-binding Rossmann-fold domains, NAD(P)-binding Rossmann-fold domains, Alcohol dehydrogenase-like C-terminal domain (Homo Multimer) 2.5Å Yes Yes
1HDZ_B (29742) Alcohol dehydrogenase 1B NAD(P)-binding Rossmann-fold domains, NAD(P)-binding Rossmann-fold domains, Alcohol dehydrogenase-like C-terminal domain 2.5Å Yes No
1HDZ_A (4197315) Alcohol dehydrogenase 1B NAD(P)-binding Rossmann-fold domains, NAD(P)-binding Rossmann-fold domains, Alcohol dehydrogenase-like C-terminal domain (Homo Multimer) 2.5Å Yes Yes
1HDZ_B (24726) Alcohol dehydrogenase 1B GroES-like, GroES-like, Alcohol dehydrogenase-like N-terminal domain 2.5Å Yes No
1HDZ_B (24726) Alcohol dehydrogenase 1B GroES-like, GroES-like, Alcohol dehydrogenase-like N-terminal domain 2.5Å Yes No
1HDZ_A (24725) Alcohol dehydrogenase 1B GroES-like, GroES-like, Alcohol dehydrogenase-like N-terminal domain 2.5Å Yes No
1HDZ_A (24725) Alcohol dehydrogenase 1B GroES-like, GroES-like, Alcohol dehydrogenase-like N-terminal domain 2.5Å Yes No
1HDZ_A (29741) Alcohol dehydrogenase 1B NAD(P)-binding Rossmann-fold domains, NAD(P)-binding Rossmann-fold domains, Alcohol dehydrogenase-like C-terminal domain 2.5Å Yes No
1HDZ_B (4197315) Alcohol dehydrogenase 1B NAD(P)-binding Rossmann-fold domains, NAD(P)-binding Rossmann-fold domains, Alcohol dehydrogenase-like C-terminal domain (Homo Multimer) 2.5Å Yes Yes
1HSZ_B (24712) Alcohol dehydrogenase 1B GroES-like, GroES-like, Alcohol dehydrogenase-like N-terminal domain 2.2Å Yes Yes
1HSZ_A (29727) Alcohol dehydrogenase 1B NAD(P)-binding Rossmann-fold domains, NAD(P)-binding Rossmann-fold domains, Alcohol dehydrogenase-like C-terminal domain 2.2Å Yes No
1HSZ_B (29728) Alcohol dehydrogenase 1B NAD(P)-binding Rossmann-fold domains, NAD(P)-binding Rossmann-fold domains, Alcohol dehydrogenase-like C-terminal domain 2.2Å Yes No
1HSZ_A (24711) Alcohol dehydrogenase 1B GroES-like, GroES-like, Alcohol dehydrogenase-like N-terminal domain 2.2Å Yes No
1HSZ_A (24711) Alcohol dehydrogenase 1B GroES-like, GroES-like, Alcohol dehydrogenase-like N-terminal domain 2.2Å Yes No
1HSZ_B (4205261) Alcohol dehydrogenase 1B NAD(P)-binding Rossmann-fold domains, NAD(P)-binding Rossmann-fold domains, Alcohol dehydrogenase-like C-terminal domain (Homo Multimer) 2.2Å Yes Yes
1HSZ_A (4205261) Alcohol dehydrogenase 1B NAD(P)-binding Rossmann-fold domains, NAD(P)-binding Rossmann-fold domains, Alcohol dehydrogenase-like C-terminal domain (Homo Multimer) 2.2Å Yes Yes
1HSZ_B (24712) Alcohol dehydrogenase 1B GroES-like, GroES-like, Alcohol dehydrogenase-like N-terminal domain 2.2Å Yes Yes
1HTB_A (4163766) Alcohol dehydrogenase 1B NAD(P)-binding Rossmann-fold domains, NAD(P)-binding Rossmann-fold domains, Alcohol dehydrogenase-like C-terminal domain (Homo Multimer) 2.37Å Yes Yes
1HTB_B (29732) Alcohol dehydrogenase 1B NAD(P)-binding Rossmann-fold domains, NAD(P)-binding Rossmann-fold domains, Alcohol dehydrogenase-like C-terminal domain 2.37Å Yes No
1HTB_A (29731) Alcohol dehydrogenase 1B NAD(P)-binding Rossmann-fold domains, NAD(P)-binding Rossmann-fold domains, Alcohol dehydrogenase-like C-terminal domain 2.37Å Yes No
1HTB_B (24716) Alcohol dehydrogenase 1B GroES-like, GroES-like, Alcohol dehydrogenase-like N-terminal domain 2.37Å Yes No
1HTB_B (24716) Alcohol dehydrogenase 1B GroES-like, GroES-like, Alcohol dehydrogenase-like N-terminal domain 2.37Å Yes No
1HTB_B (4163766) Alcohol dehydrogenase 1B NAD(P)-binding Rossmann-fold domains, NAD(P)-binding Rossmann-fold domains, Alcohol dehydrogenase-like C-terminal domain (Homo Multimer) 2.37Å Yes Yes
1HTB_A (24715) Alcohol dehydrogenase 1B GroES-like, GroES-like, Alcohol dehydrogenase-like N-terminal domain 2.37Å Yes Yes
1HTB_A (24715) Alcohol dehydrogenase 1B GroES-like, GroES-like, Alcohol dehydrogenase-like N-terminal domain 2.37Å Yes Yes
1U3U_B (113007) Alcohol dehydrogenase 1B GroES-like, GroES-like, Alcohol dehydrogenase-like N-terminal domain 1.6Å Yes Yes
1U3U_B (113007) Alcohol dehydrogenase 1B GroES-like, GroES-like, Alcohol dehydrogenase-like N-terminal domain 1.6Å Yes Yes
1U3U_A (113005) Alcohol dehydrogenase 1B GroES-like, GroES-like, Alcohol dehydrogenase-like N-terminal domain 1.6Å Yes No
1U3U_A (113005) Alcohol dehydrogenase 1B GroES-like, GroES-like, Alcohol dehydrogenase-like N-terminal domain 1.6Å Yes No
1U3U_B (113008) Alcohol dehydrogenase 1B NAD(P)-binding Rossmann-fold domains, NAD(P)-binding Rossmann-fold domains, Alcohol dehydrogenase-like C-terminal domain 1.6Å Yes No
1U3U_A (113006) Alcohol dehydrogenase 1B NAD(P)-binding Rossmann-fold domains, NAD(P)-binding Rossmann-fold domains, Alcohol dehydrogenase-like C-terminal domain 1.6Å Yes No
1U3U_B (4064809) Alcohol dehydrogenase 1B NAD(P)-binding Rossmann-fold domains, NAD(P)-binding Rossmann-fold domains, Alcohol dehydrogenase-like C-terminal domain (Homo Multimer) 1.6Å Yes Yes
1U3U_A (4064809) Alcohol dehydrogenase 1B NAD(P)-binding Rossmann-fold domains, NAD(P)-binding Rossmann-fold domains, Alcohol dehydrogenase-like C-terminal domain (Homo Multimer) 1.6Å Yes Yes
1U3V_A (113010) Alcohol dehydrogenase 1B NAD(P)-binding Rossmann-fold domains, NAD(P)-binding Rossmann-fold domains, Alcohol dehydrogenase-like C-terminal domain 1.65Å Yes No
1U3V_A (113009) Alcohol dehydrogenase 1B GroES-like, GroES-like, Alcohol dehydrogenase-like N-terminal domain 1.65Å Yes No
1U3V_B (113011) Alcohol dehydrogenase 1B GroES-like, GroES-like, Alcohol dehydrogenase-like N-terminal domain 1.65Å Yes Yes
1U3V_B (113012) Alcohol dehydrogenase 1B NAD(P)-binding Rossmann-fold domains, NAD(P)-binding Rossmann-fold domains, Alcohol dehydrogenase-like C-terminal domain 1.65Å Yes No
1U3V_B (113011) Alcohol dehydrogenase 1B GroES-like, GroES-like, Alcohol dehydrogenase-like N-terminal domain 1.65Å Yes Yes
1U3V_A (113009) Alcohol dehydrogenase 1B GroES-like, GroES-like, Alcohol dehydrogenase-like N-terminal domain 1.65Å Yes No
1U3V_A (4037099) Alcohol dehydrogenase 1B NAD(P)-binding Rossmann-fold domains, NAD(P)-binding Rossmann-fold domains, Alcohol dehydrogenase-like C-terminal domain (Homo Multimer) 1.65Å Yes Yes
1U3V_B (4037099) Alcohol dehydrogenase 1B NAD(P)-binding Rossmann-fold domains, NAD(P)-binding Rossmann-fold domains, Alcohol dehydrogenase-like C-terminal domain (Homo Multimer) 1.65Å Yes Yes
3HUD_B (4228734) Alcohol dehydrogenase 1B NAD(P)-binding Rossmann-fold domains, NAD(P)-binding Rossmann-fold domains, Alcohol dehydrogenase-like C-terminal domain (Homo Multimer) 3.2Å Yes Yes
3HUD_A (4228734) Alcohol dehydrogenase 1B NAD(P)-binding Rossmann-fold domains, NAD(P)-binding Rossmann-fold domains, Alcohol dehydrogenase-like C-terminal domain (Homo Multimer) 3.2Å Yes Yes
3HUD_A (24735) Alcohol dehydrogenase 1B GroES-like, GroES-like, Alcohol dehydrogenase-like N-terminal domain 3.2Å Yes No
3HUD_B (24736) Alcohol dehydrogenase 1B GroES-like, GroES-like, Alcohol dehydrogenase-like N-terminal domain 3.2Å Yes Yes
3HUD_A (24735) Alcohol dehydrogenase 1B GroES-like, GroES-like, Alcohol dehydrogenase-like N-terminal domain 3.2Å Yes No
3HUD_B (24736) Alcohol dehydrogenase 1B GroES-like, GroES-like, Alcohol dehydrogenase-like N-terminal domain 3.2Å Yes Yes
3HUD_A (29751) Alcohol dehydrogenase 1B NAD(P)-binding Rossmann-fold domains, NAD(P)-binding Rossmann-fold domains, Alcohol dehydrogenase-like C-terminal domain 3.2Å Yes No
3HUD_B (29752) Alcohol dehydrogenase 1B NAD(P)-binding Rossmann-fold domains, NAD(P)-binding Rossmann-fold domains, Alcohol dehydrogenase-like C-terminal domain 3.2Å Yes No
Ligand-based Druggability Score: -0.4
Ligand-based Druggability Score Percentile: 75%
Ligand-based Druggability Help: Help




		
Number of proteins in the network : 13346


ADH1B is involved in 5 interactions in the network.


Druggability
Overall Druggability Percentile: 73.09
Druggability for Cancer Therapeutics: 65.24
Druggability for Other Therapeutics: 48.68
Cancer-Associated
Cancer-associated percentile : 59.65
Network Articulation Point
Is ADH1B critical for communication in the network?


Detailed Graph Legend:Help