Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

ADH1B (P00325) - Overview - Molecular Target Synopsis

Protein


ADH1B, Alcohol dehydrogenase 1B
Enzyme Classification 1.1.1.1
UniProt P00325

Also Known as ADH1B_HUMAN, ADH1B, ADH2

Dimer of identical or non-identical chains of three types; alpha, beta and gamma.

1U3V deposition date (2004-07-23)
CRYSTAL STRUCTURE OF HUMAN ALCOHOL DEHYDROGENASE BETA-1-BETA-1 ISOFORM COMPLEXED WITH N-HEPTYLFORMAMIDE DETERMINED TO 1.65 ANGSTROM RESOLUTION
RCSB/PDB
Inspect Structure
See all 3D Structures for ADH1B

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: ADH1B is active in the following subcellular-locations: cytoplasm.
GO terms: ADH1B is active in the following subcellular-locations: cytosol, nucleoplasm, plasma membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project ADH1B has gain in 0 cell-lines, loss in 2 cell-lines and no signal in 1003 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: MCF7, SK_OV_3, TK_10

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: Hs 746T, NCI-H209, LN-18

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: NHLF, SK-N-SH, HSMM

(see details)

RNA Interference


ADH1B was reported in the following RNAI studies:

Cell - Large Scale Profiling of Kinase Dependencies in Cancer Cell Lines, the highest RNAi cell lines are: . (see details)

3D Structures


For ADH1B there are:
9 structures (18 chains) solved
9 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


ADH1B has been screened with 47 compounds (58 bioactivities), 2 compounds have bioactivities that show binding affinity of <= 500nM (2 bioactivities). (see details)