Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

camC (P00183) - Overview - Molecular Target Synopsis

Protein


camC, Camphor 5-monooxygenase
Enzyme Classification 1.14.15.1
UniProt P00183

Also Known as CPXA_PSEPU, camC, cyp101

Involved in a camphor oxidation system.

6NBL
CYTOCHROME P450CAM-PUTIDAREDOXIN COMPLEX BOUND TO CAMPHOR AND CYANIDE
RCSB/PDB
Inspect Structure
See all 3D Structures for camC

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
415P00183-1

Sub-cellular localization


UniProt: camC is active in the following subcellular-locations: cytoplasm.
GO terms: camC is active in the following subcellular-locations: cytoplasm.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project camC has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For camC there are:
125 structures (165 chains) solved
125 are solved in complex with at least one small molecule ligand
69 are solved with an approved drug

camC is solved in complex with the approved drug(s):

CAM/CAMPHOR (1AKD_A, 1DZ4_A, 1DZ4_B, 1DZ6_A, 1DZ6_B, 1DZ8_A, 1DZ8_B, 1DZ9_A, 1DZ9_B, 1GEB_A, 1IWI_A, 1IWJ_A, 1O76_A, 1O76_B, 1T85_A, 1T86_A, 1T86_B, 1T87_A, 1T87_B, 1T88_A, 1T88_B, 1UYU_A, 1UYU_B, 1YRC_A, 1YRD_A, 2A1M_A, 2A1M_B, 2A1N_A, 2A1N_B, 2A1O_A, 2A1O_B, 2CP4_A, 2CPP_A, 2FEU_A, 2FEU_B, 2L8M_A, 2M56_A, 2QBL_A, 2QBM_A, 2QBN_A, 2QBO_A, 2Z97_A, 2ZAW_A, 2ZAX_A, 2ZUH_A, 2ZUI_A, 2ZUJ_A, 2ZWT_A, 2ZWU_A, 3CPP_A, 3FWF_A, 3FWF_B, 3FWG_A, 3FWG_B, 3FWI_A, 3FWJ_A, 3L63_A, 3WRH_A, 3WRH_E, 3WRI_A, 3WRI_B, 3WRJ_A, 3WRJ_E, 3WRK_A, 3WRK_D, 3WRL_A, 3WRL_E, 3WRM_A, 3WRM_F, 4CP4_A, 4EK1_A, 4EK1_B, 4G3R_A, 4G3R_B, 4JX1_A, 4JX1_B, 4JX1_E, 4JX1_F, 4KKY_X, 4L49_A, 4L4A_A, 4L4B_A, 4L4C_A, 4L4C_B, 4L4D_A, 4L4E_A, 4L4F_A, 4L4G_A, 5CP4_A, 5IK1_A, 5WK9_A, 6CP4_A, 6NBL_A, 6NBL_B),
NCT/NICOTINE (1P2Y_A, 1P7R_A),
MYT/METYRAPONE (1PHG_A).

(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


camC has been screened with 11 compounds (18 bioactivities). (see details)