Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

CYP2B4 (P00178) - Overview - Molecular Target Synopsis

Protein


CYP2B4, Cytochrome P450 2B4
Enzyme Classification 1.14.14.1
UniProt P00178

Also Known as CP2B4_RABIT, CYP2B4

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. In the epoxidation of arachidonic acid it has a unique preference for the 5,6-olefin.

6BWW
CRYSTAL STRUCTURE OF AN ACETATE AND CYMAL-5 BOUND CYTOCHROME P450 2B4 F429H MUTANT
RCSB/PDB
Inspect Structure
See all 3D Structures for CYP2B4

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
491P00178-1

Sub-cellular localization


UniProt: CYP2B4 is active in the following subcellular-locations: endoplasmic reticulum membrane, microsome membrane.
GO terms: CYP2B4 is active in the following subcellular-locations: endoplasmic reticulum membrane, organelle membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project CYP2B4 has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For CYP2B4 there are:
21 structures (52 chains) solved
21 are solved in complex with at least one small molecule ligand
5 are solved with an approved drug

CYP2B4 is solved in complex with the approved drug(s):

CGE/CLOPIDOGREL (3ME6_A, 3ME6_B, 3ME6_C, 3ME6_D, 4H1N_A),
SUC/SUCROSE (3R1B_A, 3R1B_B, 3R1B_C, 3R1B_D),
8PR/PAROXETINE (4JLT_A),
TIC/TICLOPIDINE (3KW4_A).

(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


CYP2B4 has been screened with 13 compounds (30 bioactivities). (see details)