Molecular Target Synopsis
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(P00138) - Druggability - Molecular Target Synopsis

Chain-based assessment (last updated 03/09/2019)
Domain-based assessment (last updated 30/07/2012)


Structural Druggability Help: Help

Chain-based assessment (last updated 03/09/2019)


Chains assessed51
Chains with at least one site assessed as druggable using the strict criteria0
Chains with at least one site assessed as druggable using the relaxed criteria7


		
PDB Chain Protein Name Druggable Relaxed Druggable Strict Details
1E86_A Cytochrome c' No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.38 67.7 12.8 No No
2 empty 3.01 62.7 15.2 No No
3 bound 1.85 56.2 12.3 No No
4 empty 2.01 66.5 9.7 No No
5 empty 2.03 72.1 8.2 No No
6 empty 1.85 69.1 8.1 No No
7 empty 2.48 61.6 10.8 No No
8 empty 1.72 71.4 6.2 No No
9 empty 2.03 65.6 7 No No
10 empty 2.11 62.5 8 No No
3ZTM_A Cytochrome c' No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.85 61.5 19.7 No No
2 empty 2.69 62.7 21.4 No No
3 empty 1.88 65.3 9.9 No No
4 empty 1.85 68.6 10.6 No No
5 empty 2.2 70.9 9 No No
6 empty 1.89 74.8 0 No No
7 empty 2.46 58.6 11.7 No No
8 empty 1.93 59.7 9.8 No No
9 empty 2.43 48.1 8.7 No No
10 empty 1.77 70 6.7 No No
2XL6_A Cytochrome c' No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.8 58.4 17.8 No No
2 empty 1.83 66.7 14.4 No No
3 empty 1.91 64.9 10.6 No No
4 empty 1.73 71.1 9.1 No No
5 empty 2.02 70.9 8.6 No No
6 empty 2.55 61.1 9.3 No No
7 empty 3 66.4 7.3 No No
8 empty 1.83 68.1 8 No No
9 empty 1.81 69.2 8.8 No No
10 empty 2.52 75.9 8.5 No No
5JT4_A Cytochrome c' No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.86 63.6 19.1 No No
2 bound 2.3 62.4 27 No No
3 empty 1.87 64.7 8.9 No No
4 empty 2.02 69.8 8 No No
5 empty 2.04 64.2 9.9 No No
6 empty 2.2 66.9 8.3 No No
7 empty 2.01 60.6 7.2 No No
8 empty 2.57 66.4 5.3 No No
9 empty 1.88 76 7 No No
10 empty 3.64 61.4 6.4 No No
2YLD_A Cytochrome c' No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.82 64.9 14.3 No No
2 bound 2.25 62.3 23.9 No No
3 empty 1.92 67.1 11.5 No No
4 empty 1.93 65.7 7.6 No No
5 empty 1.76 64 9.5 No No
6 empty 2.52 61.7 10.6 No No
7 empty 1.69 71 7.4 No No
8 empty 1.89 70.1 8.2 No No
9 empty 2.49 67.1 7.5 No No
10 empty 2.06 58.9 8.8 No No
5JVE_A Cytochrome c' No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.67 65.2 13.3 No No
2 empty 1.2 58.6 14.7 No No
3 empty 2.06 68.8 7.4 No No
4 empty 1.93 67.3 9.4 No No
5 empty 2.24 76.8 8 No No
6 empty 2.61 56.2 11 No No
7 empty 1.99 51 9.4 No No
8 empty 1.56 67.8 6.5 No No
9 empty 2.68 67.6 0 No No
10 empty 2.27 54.4 8.3 No No
1E84_A Cytochrome c' Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.26 60.7 28.1 Yes No
2 empty 1.36 67.7 12.5 No No
3 empty 3.03 62.1 13.3 No No
4 empty 1.86 59 10.8 No No
5 empty 2.2 70.4 9.1 No No
6 empty 1.79 74.9 6.8 No No
7 empty 2.6 48.7 7 No No
8 empty 2.06 63.6 7.7 No No
9 empty 2.34 61.8 8.1 No No
10 empty 1.96 61.4 7.1 No No
2XL8_A Cytochrome c' No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.82 68.1 14.4 No No
2 empty 1.83 68.9 10.1 No No
3 empty 2.2 72 7.9 No No
4 empty 1.39 56.4 10.6 No No
5 empty 2.23 67.7 8.9 No No
6 empty 1.74 71.7 10 No No
7 empty 2.29 68.6 5 No No
8 empty 1.71 69 7 No No
9 empty 2.96 62.5 8 No No
10 empty 2.05 56 9.1 No No
4D4X_A Cytochrome c' No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.85 65 19.4 No No
2 empty 2.16 62.1 20.3 No No
3 empty 1.81 63.7 10.1 No No
4 empty 2.37 67.3 9.9 No No
5 empty 2.33 68.4 8 No No
6 empty 2.24 69.6 10.6 No No
7 empty 1.92 71.8 5.1 No No
8 empty 1.83 72.6 7.9 No No
9 empty 2.42 64.7 8.2 No No
10 empty 1.96 76.8 7.1 No No
5JP7_A Cytochrome c' No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.95 67 13.6 No No
2 empty 2.28 61 17.5 No No
3 empty 1.95 68.3 8.7 No No
4 empty 2.03 63.1 9 No No
5 empty 2.33 66.9 8.5 No No
6 empty 2.55 65.2 7 No No
7 empty 1.74 62.8 8.7 No No
8 empty 1.91 71.8 0 No No
9 empty 1.47 75 5 No No
10 empty 2.26 71 7 No No
1E83_A Cytochrome c' No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.33 68.3 12.4 No No
2 empty 2.15 57.2 26.3 No No
3 empty 1.87 60.9 11.2 No No
4 empty 1.92 64.8 11.1 No No
5 empty 2.12 74.4 7.7 No No
6 empty 2.95 58 9.4 No No
7 empty 1.77 73.8 7.3 No No
8 empty 2.04 63 9.3 No No
9 empty 2.85 60.9 6.7 No No
10 empty 1.86 65.6 6.1 No No
4D4N_A Cytochrome c' No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.87 63.3 16.5 No No
2 empty 2.01 59.1 15.6 No No
3 empty 1.91 65.8 10.2 No No
4 empty 2.09 72.5 9 No No
5 empty 1.8 67.1 9.1 No No
6 empty 2.09 73.8 6.8 No No
7 empty 1.95 69.4 6.8 No No
8 empty 2.37 69.8 7.6 No No
9 empty 2.06 71.2 6.8 No No
10 empty 1.88 59.4 7.6 No No
5JRA_A Cytochrome c' No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.92 61.9 15.2 No No
2 bound 1.24 59.1 14.2 No No
3 bound 2.79 64.5 15.1 No No
4 empty 1.93 69 10 No No
5 empty 1.98 66.5 8.9 No No
6 empty 1.92 71.2 6.1 No No
7 empty 2.29 74.9 0 No No
8 empty 1.85 66.2 6.4 No No
9 empty 2.8 61.2 10.7 No No
10 empty 2.3 73.4 5.3 No No
5JSL_A Cytochrome c' Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.73 61.4 34.6 Yes No
2 empty 1.84 65.4 13.3 No No
3 empty 2.28 69.7 9 No No
4 empty 1.96 69 8.5 No No
5 empty 2.45 65.4 14.5 No No
6 empty 2.32 72.3 10 No No
7 empty 1.76 68.4 7.3 No No
8 empty 2.53 68.2 7.2 No No
9 empty 1.89 55.9 8.8 No No
10 empty 2.15 81.7 5.6 No No
2YL3_A Cytochrome c' No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.82 61.3 17.1 No No
2 empty 1.91 61.3 15.5 No No
3 empty 1.88 69 9.8 No No
4 empty 2.25 66.7 12.4 No No
5 empty 2.26 66.9 9.3 No No
6 empty 1.75 67.2 9.1 No No
7 empty 2.51 60.4 11.6 No No
8 empty 2.33 62.3 10.6 No No
9 empty 2.45 74.4 8.6 No No
10 empty 2.06 70.1 6.7 No No
4WGY_A Cytochrome c' No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.37 58.8 22.4 No No
2 empty 1.4 63.1 14.8 No No
3 empty 1.85 60.4 11.4 No No
4 empty 1.91 64.7 9.9 No No
5 empty 2.09 71.9 7.4 No No
6 empty 1.69 72.8 10.9 No No
7 empty 2.57 65.9 12.3 No No
8 empty 2.12 62.6 6.1 No No
9 empty 1.81 64.1 6.8 No No
10 empty 1.85 61.4 7.4 No No
5JLI_A Cytochrome c' No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.79 62.3 16.4 No No
2 bound 1.74 58.2 16.2 No No
3 empty 2.46 62.3 11.4 No No
4 empty 1.96 59.8 10.1 No No
5 empty 1.65 63.8 8.6 No No
6 empty 2 73.4 7.3 No No
7 empty 1.94 68.4 6.7 No No
8 empty 2.45 57.9 9.7 No No
9 empty 2.6 57.7 7 No No
10 empty 2.59 54.2 8.9 No No
4CDA_A Cytochrome c' No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.82 66.9 13.8 No No
2 empty 2.45 54.8 18.6 No No
3 empty 2.77 55.3 12.1 No No
4 empty 2 65.8 10.2 No No
5 empty 1.39 60.3 14.8 No No
6 empty 2.22 67.1 8.3 No No
7 empty 2.38 70.8 9.6 No No
8 empty 1.97 71 7.8 No No
9 empty 2.31 67 7 No No
10 empty 2.43 51.2 8 No No
2XLE_A Cytochrome c' Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.56 59.2 24.1 Yes No
2 empty 1.79 64.9 17.2 No No
3 empty 1.97 69.7 11.1 No No
4 empty 2.24 72 9.4 No No
5 empty 2.21 65.7 8.7 No No
6 empty 1.73 69.4 8.7 No No
7 empty 1.98 70.1 7.4 No No
8 empty 2.1 49.4 9.7 No No
9 empty 2.76 58.3 8.6 No No
10 empty 2.28 74.6 0 No No
3ZQY_A Cytochrome c' No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.81 62.8 19.2 No No
2 empty 2.24 61.8 19.6 No No
3 empty 2.06 67.3 9.2 No No
4 empty 1.93 68.7 10.5 No No
5 empty 2.25 70.5 9.1 No No
6 empty 2.52 63.7 11.4 No No
7 empty 2.46 54.3 7.5 No No
8 empty 2.02 75.7 0 No No
9 empty 2.58 68.5 7.8 No No
10 empty 1.86 75.2 7.3 No No
5NC0_A Cytochrome c' No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.09 60.3 22.5 No No
2 empty 1.87 67.3 14.6 No No
3 empty 1.91 63.2 11.5 No No
4 empty 2.22 71.6 10.7 No No
5 bound 2.89 55.2 9.5 No No
6 empty 1.8 74.3 6.9 No No
7 empty 1.85 69 9.4 No No
8 empty 1.8 65.1 8.3 No No
9 bound 2.51 74.3 7.9 No No
10 bound 3.74 76.4 5.2 No No
2XM4_A Cytochrome c' No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.67 61.5 20.1 No No
2 empty 1.8 65.5 13.9 No No
3 empty 1.9 67.9 9.7 No No
4 empty 1.64 57.2 15.6 No No
5 empty 2.27 69.3 9.2 No No
6 empty 2.23 72.8 7.9 No No
7 empty 1.92 53.3 8.4 No No
8 empty 1.73 64.4 6.2 No No
9 empty 2.52 53.8 7.6 No No
10 empty 2.36 64.7 5 No No
4CJO_A Cytochrome c' No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.91 67.9 14.5 No No
2 empty 1.98 67.2 11 No No
3 empty 1.52 56.9 13.9 No No
4 empty 2.26 73.2 7.4 No No
5 empty 2.5 66.7 13.7 No No
6 empty 2.03 56.8 12.3 No No
7 empty 2.53 71.7 8.4 No No
8 empty 2.03 66 7.9 No No
9 empty 3.73 71.2 6.9 No No
10 empty 1.83 67.6 5.7 No No
3ZQV_A Cytochrome c' No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.62 66.1 11.5 No No
2 empty 2.75 58.3 12.5 No No
3 empty 1.95 68.8 9.5 No No
4 empty 1.96 70.5 8.4 No No
5 empty 2.16 72.6 9.6 No No
6 empty 1.39 55.5 10.1 No No
7 empty 1.89 76.6 0 No No
8 empty 2.12 62.3 8.6 No No
9 empty 2.24 51.9 8.5 No No
10 empty 2.21 60.3 4.8 No No
5AGF_A Cytochrome c' No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.89 65.9 14.6 No No
2 empty 2.04 55.1 15.5 No No
3 empty 1.83 64.1 10 No No
4 empty 2.37 69.5 10.7 No No
5 empty 2.3 72.9 8.3 No No
6 empty 1.94 68.1 10.3 No No
7 empty 2.28 59.7 7.3 No No
8 empty 2.43 58.5 12 No No
9 empty 2.86 61.2 6.4 No No
10 empty 1.94 70.7 7.2 No No
2XLO_A Cytochrome c' No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.42 65.8 13.8 No No
2 empty 1.5 59.9 15.9 No No
3 empty 1.89 68.2 9.4 No No
4 empty 2.24 72.1 8 No No
5 empty 1.65 66.7 8.7 No No
6 empty 1.79 74.1 7.7 No No
7 empty 1.93 67.9 6.3 No No
8 empty 1.76 62.4 9.6 No No
9 empty 2.55 71.6 0 No No
10 empty 3.32 60.3 7.9 No No
2XLD_A Cytochrome c' No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.41 68.1 11.8 No No
2 empty 1.82 57.1 16.5 No No
3 empty 1.99 68.8 9.8 No No
4 empty 2.09 71.2 9.9 No No
5 empty 1.92 73.8 10.7 No No
6 empty 1.51 66 7.6 No No
7 empty 1.89 66 6.1 No No
8 empty 2.03 78.2 8 No No
9 empty 1.63 76.7 0 No No
10 empty 2.82 68.8 0 No No
5JUA_A Cytochrome c' No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.96 63.4 17.5 No No
2 empty 2.35 60.1 24.4 No No
3 empty 1.67 65.2 9.2 No No
4 empty 2.04 72.1 7.7 No No
5 empty 2 65.2 8.6 No No
6 empty 2.35 72.5 8.5 No No
7 empty 2.73 72.3 5.8 No No
8 empty 2 54.1 9.9 No No
9 empty 2.66 66.9 6.5 No No
10 empty 1.1 56.5 6.3 No No
5JS5_A Cytochrome c' No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.84 65.2 15.7 No No
2 bound 1.58 59.7 17.7 No No
3 empty 2.26 71.9 7.9 No No
4 empty 1.95 66.5 9.6 No No
5 empty 1.88 67.9 8.2 No No
6 empty 2.52 62.8 11.9 No No
7 empty 2.17 72.1 8 No No
8 empty 2.58 66.9 7.2 No No
9 empty 1.72 56.5 8.7 No No
10 empty 2.18 70.1 7.6 No No
4CDV_A Cytochrome c' No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.84 63.9 13.8 No No
2 empty 2.64 56.9 16.4 No No
3 empty 1.86 64.3 9.7 No No
4 empty 1.36 59.9 13.4 No No
5 empty 2.25 68.7 7.6 No No
6 empty 2.21 70.4 9.3 No No
7 empty 2.28 71.1 8.3 No No
8 empty 2.25 56.7 8.9 No No
9 empty 1.95 73.6 0 No No
10 empty 2.45 49.7 7.5 No No
2YKZ_A Cytochrome c' No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.62 66.4 11.1 No No
2 empty 2.75 53 16.5 No No
3 empty 1.94 68.1 9.5 No No
4 empty 1.93 54.6 16.5 No No
5 empty 1.92 67.9 8.4 No No
6 empty 2.16 72.2 9.6 No No
7 empty 1.74 66.1 8.2 No No
8 empty 2.43 70.3 0 No No
9 empty 1.89 75.9 0 No No
10 empty 2.06 61.2 8 No No
2YL1_A Cytochrome c' No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.83 61.7 15.2 No No
2 empty 1.78 61.8 15.1 No No
3 empty 2.07 68.6 9.2 No No
4 empty 2.01 66.7 10.5 No No
5 empty 2.26 71.8 9.1 No No
6 empty 3.05 60.9 8.8 No No
7 empty 2.5 64.3 11.7 No No
8 empty 1.94 72 0 No No
9 empty 2.42 52.2 8.4 No No
10 empty 2.48 66.9 8 No No
2XLW_A Cytochrome c' No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.85 64.1 14 No No
2 empty 2.11 61.4 14.8 No No
3 empty 1.89 69.5 11.4 No No
4 empty 1.89 70.5 7.9 No No
5 empty 2.42 70.8 8.2 No No
6 empty 1.61 62 11.9 No No
7 empty 2.16 61.4 11.3 No No
8 empty 1.97 72.5 7.4 No No
9 empty 2.46 75 6 No No
10 empty 2.25 74.8 8 No No
5NGX_A Cytochrome c' Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.3 59.2 32.1 Yes No
2 empty 1.78 62.1 15.2 No No
3 empty 2.07 63.4 11.4 No No
4 empty 2.06 70.8 11.2 No No
5 empty 2.19 70.6 9 No No
6 empty 1.74 67.5 5.9 No No
7 empty 1.83 69.8 7.3 No No
8 empty 2.54 67.4 8.4 No No
9 empty 3.67 71.9 6.7 No No
10 empty 2.11 57.3 9.9 No No
4CIP_A Cytochrome c' No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.56 65.8 12.5 No No
2 empty 2.64 60.7 12.4 No No
3 bound 1.4 58.6 13.2 No No
4 empty 2.02 66.1 9.1 No No
5 empty 2.25 70.5 8.2 No No
6 empty 1.68 65.5 8.7 No No
7 empty 2.2 53.8 11.3 No No
8 empty 2.03 70.2 6.2 No No
9 empty 2.57 59.9 11.5 No No
10 empty 2.44 58.6 7.5 No No
2XLV_A Cytochrome c' No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.72 66.3 15.3 No No
2 empty 1.47 59.7 13.1 No No
3 empty 2.19 74 15 No No
4 empty 1.86 66.5 10.7 No No
5 empty 2.06 71 7.9 No No
6 empty 1.97 67.9 8.6 No No
7 empty 2.68 69.5 8.2 No No
8 empty 1.96 57.8 9.7 No No
9 empty 2.14 71.8 7 No No
10 empty 2.08 72.8 9.1 No No
1CGO_A Cytochrome c' No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.39 69.2 11.9 No No
2 empty 2.06 67.4 8 No No
3 empty 1.68 67.5 10.1 No No
4 empty .95 53.4 12.5 No No
5 empty 2.48 59 12 No No
6 empty 2.12 57.9 10.3 No No
7 empty 1.82 72.9 6.5 No No
8 empty 1.67 71.9 6 No No
9 empty 1.58 76 0 No No
10 empty 1.35 80.2 6 No No
1CGN_A Cytochrome c' Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.51 71.9 9.2 Yes No
2 empty 2.05 69.5 10.7 No No
3 empty 2.09 68.5 7.8 No No
4 empty 1.66 69.3 5.8 No No
5 empty .72 48.8 13.2 No No
6 empty 1.91 70.4 6.2 No No
7 empty 1.63 77.7 5.9 No No
8 empty 1.41 76.7 5.5 No No
9 empty 2.26 55.3 8.2 No No
10 empty 1.85 62.2 7.1 No No
1E85_A Cytochrome c' Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.22 60.5 28.9 Yes No
2 empty 1.37 65.2 14.5 No No
3 empty 1.88 61.6 11.3 No No
4 empty 2.05 70.5 8.2 No No
5 empty 1.87 70 6.6 No No
6 empty 1.67 67.7 6.3 No No
7 empty 2.09 65.6 6.5 No No
8 empty 2.53 48.6 9 No No
9 empty 2.14 59.5 9.6 No No
10 empty 1.93 63.9 7.8 No No
2YL7_A Cytochrome c' No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.83 64.1 19.4 No No
2 empty 1.95 62.5 12.8 No No
3 empty 3.23 61.9 15.6 No No
4 empty 1.9 62.6 9.2 No No
5 empty 1.83 66.7 12.1 No No
6 empty 2.22 68.1 10.9 No No
7 empty 2.44 58.6 11 No No
8 empty 2.37 50 9.5 No No
9 empty 1.87 73.8 0 No No
10 empty 1.76 69.4 6.7 No No
4WGZ_A Cytochrome c' No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.9 61.4 20.3 No No
2 empty 2.73 63.1 13 No No
3 empty 1.83 64.2 10.7 No No
4 empty 2.1 67.5 14.9 No No
5 empty 1.59 59.1 11.4 No No
6 empty 2.2 67.5 9.1 No No
7 empty 1.6 64.9 8.4 No No
8 empty 1.86 73.5 7.3 No No
9 empty 1.92 57.7 9.3 No No
10 empty 1.93 74.4 7.7 No No
2XM0_A Cytochrome c' No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.51 68.4 9.9 No No
2 empty 1.89 68.3 9.7 No No
3 empty 1.4 52.6 13.4 No No
4 empty 1.93 70 8.6 No No
5 empty 2.41 75.1 7.6 No No
6 empty 1.93 66.1 7.2 No No
7 empty 1.84 71.5 5.6 No No
8 empty 2.21 74.4 7.9 No No
9 empty 1.9 74.3 7.7 No No
10 empty 2.25 73 6 No No
4CDY_A Cytochrome c' No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.92 65.1 14.8 No No
2 empty 2.33 60.1 22 No No
3 empty 1.84 69.7 11 No No
4 empty 2.21 72.2 7.9 No No
5 empty 1.95 64.7 8.6 No No
6 empty 2.21 53.8 12.2 No No
7 empty 2.58 80.1 7.2 No No
8 empty 1.89 65.2 6.1 No No
9 empty 2.27 59.9 9.1 No No
10 empty 1.99 71.4 6.4 No No
2YLG_A Cytochrome c' No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.9 62.6 15.1 No No
2 bound 2.07 61.9 14.7 No No
3 empty 1.89 64.1 9.8 No No
4 empty 2.68 60.1 10.3 No No
5 empty 1.88 68.4 10.6 No No
6 empty 2.24 64.6 8.8 No No
7 empty 1.93 77.2 0 No No
8 empty 2.43 62.4 8.9 No No
9 empty 2.46 68.4 7.8 No No
10 empty 2.47 60.3 10.2 No No
2YL0_A Cytochrome c' No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.45 60.6 23.1 No No
2 empty 1.84 63.6 14.4 No No
3 empty 1.84 63.3 9.5 No No
4 empty 2.16 66 9.2 No No
5 empty 1.86 66.9 10.6 No No
6 empty 1.71 56.3 11.1 No No
7 empty 2.28 59.7 8.9 No No
8 empty 2.45 52.5 9.1 No No
9 empty 2.38 62.8 10.2 No No
10 empty 2.04 69.7 6.7 No No
2XLH_A Cytochrome c' No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.8 63 17.2 No No
2 empty 2.11 58.5 13.8 No No
3 empty 1.86 66.2 11.6 No No
4 empty 2.2 71.1 9 No No
5 empty 3.06 67.1 9.5 No No
6 empty 2.19 68.5 8.2 No No
7 empty 2.12 59.1 9.9 No No
8 empty 2.23 52.1 8.3 No No
9 empty 2.12 71.1 7.1 No No
10 empty 2.25 59 6.4 No No
4CJG_A Cytochrome c' No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.69 67.7 12.7 No No
2 empty 1.68 63.2 16.8 No No
3 empty 2.02 68.3 9.7 No No
4 empty 2.28 70.4 7.9 No No
5 empty 1.65 62.2 9.2 No No
6 empty 2.32 69.9 8.2 No No
7 empty 2.34 69 6.8 No No
8 empty 1.96 55.2 9.1 No No
9 empty 2.13 71.2 7.2 No No
10 empty 2.92 66.7 6.6 No No
2YLI_A Cytochrome c' Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.71 60.7 25.4 Yes No
2 empty 1.84 66.4 13.9 No No
3 empty 1.88 58.4 16.6 No No
4 empty 1.95 66.8 9.1 No No
5 empty 2.24 70.4 7.6 No No
6 empty 2.31 72.6 9.2 No No
7 empty 2.23 76.3 7.8 No No
8 empty 2.27 57.1 12.4 No No
9 empty 1.74 73.4 8.1 No No
10 empty 2.12 60 10.1 No No
2XLM_A Cytochrome c' No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.84 63.1 14.7 No No
2 empty 1.92 60.6 11.9 No No
3 empty 2.28 73.4 14.8 No No
4 empty 1.96 64.4 11 No No
5 empty 2.27 71.2 8.6 No No
6 empty 2.87 59.7 15.8 No No
7 empty 1.69 63.7 9.5 No No
8 empty 1.87 52.1 10.2 No No
9 empty 1.88 71.9 7.4 No No
10 empty 2.15 65.8 8.9 No No
3ZTZ_A Cytochrome c' No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.8 61.4 18.4 No No
2 empty 1.94 61.2 12.7 No No
3 empty 1.84 67.1 9.5 No No
4 empty 1.94 67.7 12.4 No No
5 empty 2.28 65.9 9.3 No No
6 empty 1.84 67.9 8.2 No No
7 empty 2.5 65.6 10.5 No No
8 empty 2.45 73.7 8.6 No No
9 empty 1.81 69.4 6.7 No No
10 empty 2.38 64.4 9.8 No No
3ZWI_A Cytochrome c' No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.82 64.4 13.6 No No
2 bound 2.21 63.6 23.6 No No
3 empty 1.94 65.6 11.5 No No
4 empty 1.93 65 7.4 No No
5 empty 1.76 68.6 8.5 No No
6 empty 2.53 60.3 10.8 No No
7 empty 1.95 68.8 7.6 No No
8 empty 2.52 67.3 7.5 No No
9 empty 1.81 72.8 6.7 No No
10 empty 1.95 71.5 8.6 No No

Domain-based assessment (last updated 30/07/2012)


Domains assessed28
Domains assessed as druggable using the strict criteria0
Domains assessed as druggable using the relaxed criteria4

PDB (Domain) Protein Name Domain Resolution Ligands Druggable Relaxed Druggable Strict
1CGN_A (16548) Cytochrome c' Four-helical up-and-down bundle, Cytochromes, Cytochrome c -like 2.15Å Yes No
1CGO_A (16550) Cytochrome c' Four-helical up-and-down bundle, Cytochromes, Cytochrome c -like 1.8Å No No
1E83_A (16553) Cytochrome c' Four-helical up-and-down bundle, Cytochromes, Cytochrome c -like 2.05Å No No
1E84_A (16552) Cytochrome c' Four-helical up-and-down bundle, Cytochromes, Cytochrome c -like 1.9Å Yes No
1E85_A (16549) Cytochrome c' Four-helical up-and-down bundle, Cytochromes, Cytochrome c -like 1.35Å Yes No
1E86_A (16551) Cytochrome c' Four-helical up-and-down bundle, Cytochromes, Cytochrome c -like 1.95Å No No
2XL6_A (3580654) Cytochrome c' Four-helical up-and-down bundle, Cytochromes, Cytochrome c -like 1.07Å No No
2XL8_A (4244133) Cytochrome c' Four-helical up-and-down bundle, Cytochromes, Cytochrome c -like 1.14Å No No
2XLD_A (3580655) Cytochrome c' Four-helical up-and-down bundle, Cytochromes, Cytochrome c -like 1.4Å No No
2XLE_A (3580656) Cytochrome c' Four-helical up-and-down bundle, Cytochromes, Cytochrome c -like 1.12Å Yes No
2XLH_A (4013058) Cytochrome c' Four-helical up-and-down bundle, Cytochromes, Cytochrome c -like 1.14Å No No
2XLM_A (3580657) Cytochrome c' Four-helical up-and-down bundle, Cytochromes, Cytochrome c -like 1.189Å No No
2XLO_A (3580660) Cytochrome c' Four-helical up-and-down bundle, Cytochromes, Cytochrome c -like 1.14Å No No
2XLV_A (3580664) Cytochrome c' Four-helical up-and-down bundle, Cytochromes, Cytochrome c -like 1.24Å No No
2XLW_A (3580665) Cytochrome c' Four-helical up-and-down bundle, Cytochromes, Cytochrome c -like 1.17Å No No
2XM0_A (3580669) Cytochrome c' Four-helical up-and-down bundle, Cytochromes, Cytochrome c -like 1.25Å No No
2XM4_A (3580678) Cytochrome c' Four-helical up-and-down bundle, Cytochromes, Cytochrome c -like 1.1Å No No
2YKZ_A (4232480) Cytochrome c' Four-helical up-and-down bundle, Cytochromes, Cytochrome c -like .84Å No No
2YL0_A (4125238) Cytochrome c' Four-helical up-and-down bundle, Cytochromes, Cytochrome c -like .93Å No No
2YL1_A (4228968) Cytochrome c' Four-helical up-and-down bundle, Cytochromes, Cytochrome c -like 1.03Å No No
2YL3_A (4061157) Cytochrome c' Four-helical up-and-down bundle, Cytochromes, Cytochrome c -like 1.04Å No No
2YL7_A (4252067) Cytochrome c' Four-helical up-and-down bundle, Cytochromes, Cytochrome c -like .895Å No No
2YLD_A (4108631) Cytochrome c' Four-helical up-and-down bundle, Cytochromes, Cytochrome c -like 1.25Å No No
2YLG_A (4209184) Cytochrome c' Four-helical up-and-down bundle, Cytochromes, Cytochrome c -like 1.05Å No No
3ZQV_A (4086096) Cytochrome c' Four-helical up-and-down bundle, Cytochromes, Cytochrome c -like .84Å No No
3ZQY_A (4212268) Cytochrome c' Four-helical up-and-down bundle, Cytochromes, Cytochrome c -like 1.03Å No No
3ZTM_A (4009329) Cytochrome c' Four-helical up-and-down bundle, Cytochromes, Cytochrome c -like .9Å No No
3ZTZ_A (4007023) Cytochrome c' Four-helical up-and-down bundle, Cytochromes, Cytochrome c -like 1.04Å No No
Ligand-based Druggability Score:
Ligand-based Druggability Score Percentile: %
Ligand-based Druggability Help: Help




		
This protein has no network-based druggability score