Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
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Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
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MOCS2 (O96033) - Overview - Molecular Target Synopsis

Protein


MOCS2, Molybdopterin synthase sulfur carrier subunit
UniProt O96033

Also Known as MOC2A_HUMAN, MOCS2, MOCO1

Acts as a sulfur carrier required for molybdopterin biosynthesis. Component of the molybdopterin synthase complex that catalyzes the conversion of precursor Z into molybdopterin by mediating the incorporation of 2 sulfur atoms into precursor Z to generate a dithiolene group. In the complex, serves as sulfur donor by being thiocarboxylated (-COSH) at its C-terminus by MOCS3. After interaction with MOCS2B, the sulfur is then transferred to precursor Z to form molybdopterin. Heterotetramer; composed of 2 small (MOCS2A) and 2 large (MOCS2B) subunits.

5MPO
CRYSTAL STRUCTURE OF HUMAN MOLYBDOPTERIN SYNTHASE COMPLEX
RCSB/PDB
Inspect Structure
See all 3D Structures for MOCS2

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: MOCS2 is active in the following subcellular-locations: cytoplasm, cytosol.
GO terms: MOCS2 is active in the following subcellular-locations: cytosol, molybdopterin synthase complex.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project MOCS2 has gain in 0 cell-lines, loss in 3 cell-lines and no signal in 1002 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: T47D, SF_295, SNB_19

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: TYK-nu.CP-r, LN-18, A-375

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: NHLF, MCF-7, AG445

(see details)

3D Structures


For MOCS2 there are:
1 structures (2 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis