Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

AGR2 (O95994) - Overview - Molecular Target Synopsis

Protein


AGR2, Anterior gradient protein 2 homolog
UniProt O95994

Also Known as AGR2_HUMAN, AGR2, AG2

Required for MUC2 post-transcriptional synthesis and secretion. May play a role in the production of mucus by intestinal cells (By similarity). Proto-oncogene that may play a role in cell migration, cell differentiation and cell growth. Promotes cell adhesion (PubMed:23274113). Monomer and homodimer (PubMed:23274113). Interacts with LYPD3 and DAG1 (alphaDAG1). Interacts with MUC2; disulfide-linked.

2LNS
SOLUTION STRUCTURE OF AGR2 RESIDUES 41-175
RCSB/PDB
Inspect Structure
See all 3D Structures for AGR2

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: AGR2 is active in the following subcellular-locations: endoplasmic reticulum, secreted.
GO terms: AGR2 is active in the following subcellular-locations: endoplasmic reticulum, extracellular space.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project AGR2 has gain in 16 cell-lines, loss in 2 cell-lines and no signal in 987 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: KM12, T47D, NCI_H322M

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: MFM-223, LS 174T, NCI-H716

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: MCF-7, A549, SK-N-SH

(see details)

3D Structures


For AGR2 there are:
2 structures (3 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis