Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

AIFM1 (O95831) - Overview - Molecular Target Synopsis

Protein


AIFM1, Apoptosis-inducing factor 1, mitochondrial
Enzyme Classification 1.1.1.-
UniProt O95831

Also Known as AIFM1_HUMAN, AIFM1, AIF, PDCD8

Functions both as NADH oxidoreductase and as regulator of apoptosis. In response to apoptotic stimuli, it is released from the mitochondrion intermembrane space into the cytosol and to the nucleus, where it functions as a proapoptotic factor in a caspase-independent pathway. In contrast, functions as an antiapoptotic factor in normal mitochondria via its NADH oxidoreductase activity. The soluble form (AIFsol) found in the nucleus induces 'parthanatos' i.e. caspase-independent fragmentation of chromosomal DNA. Interacts with EIF3G,and thereby inhibits the EIF3 machinery and protein synthesis, and activates casapse-7 to amplify apoptosis. Plays a critical role in caspase-independent, pyknotic cell death in hydrogen peroxide-exposed cells. Binds to DNA in a sequence-independent manner. Monomer (oxidized form). Homodimer (reduced form). Also dimerizes with isoform 3 preventing its release from mitochondria. Interacts with XIAP/BIRC4. Interacts (via N-terminus) with EIF3G (via C-terminus). Interacts with PRELID1.

5FMH
CRYSTAL STRUCTURE OF THE E405K MUTANT OF HUMAN APOPTOSIS INDUCING FACTOR
RCSB/PDB
Inspect Structure
See all 3D Structures for AIFM1

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: AIFM1 is active in the following subcellular-locations: cytoplasm, mitochondrion inner membrane, mitochondrion intermembrane space, nucleus, perinuclear region.
GO terms: AIFM1 is active in the following subcellular-locations: cytosol, mitochondrial inner membrane, mitochondrial intermembrane space, mitochondrion, nucleus, perinuclear region of cytoplasm.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project AIFM1 has gain in 0 cell-lines, loss in 26 cell-lines and no signal in 979 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: BT_549, SW_620, HL_60

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: SK23, GTL-16, Okajima

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: A549, SK-N-SH, NHLF

(see details)

3D Structures


For AIFM1 there are:
12 structures (19 chains) solved
12 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis