AIFM1 (O95831) - Overview - Molecular Target Synopsis
AIFM1, Apoptosis-inducing factor 1, mitochondrial
Enzyme Classification 1.1.1.-
Also Known as AIFM1_HUMAN, AIFM1, AIF, PDCD8
Functions both as NADH oxidoreductase and as regulator of apoptosis. In response to apoptotic stimuli, it is released from the mitochondrion intermembrane space into the cytosol and to the nucleus, where it functions as a proapoptotic factor in a caspase-independent pathway. In contrast, functions as an antiapoptotic factor in normal mitochondria via its NADH oxidoreductase activity. The soluble form (AIFsol) found in the nucleus induces 'parthanatos' i.e. caspase-independent fragmentation of chromosomal DNA. Interacts with EIF3G,and thereby inhibits the EIF3 machinery and protein synthesis, and activates casapse-7 to amplify apoptosis. Plays a critical role in caspase-independent, pyknotic cell death in hydrogen peroxide-exposed cells. Binds to DNA in a sequence-independent manner. Monomer (oxidized form). Homodimer (reduced form). Also dimerizes with isoform 3 preventing its release from mitochondria. Interacts with XIAP/BIRC4. Interacts (via N-terminus) with EIF3G (via C-terminus). Interacts with PRELID1.
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UniProt: AIFM1 is active in the following subcellular-locations: cytoplasm, mitochondrion inner membrane, mitochondrion intermembrane space, nucleus, perinuclear region.
GO terms: AIFM1 is active in the following subcellular-locations: cytosol, mitochondrial inner membrane, mitochondrial intermembrane space, mitochondrion, nucleus, perinuclear region of cytoplasm.