Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

MLYCD (O95822) - Overview - Molecular Target Synopsis

Protein


MLYCD, Malonyl-CoA decarboxylase, mitochondrial
Enzyme Classification 4.1.1.9
UniProt O95822

Also Known as DCMC_HUMAN, MLYCD

Catalyzes the conversion of malonyl-CoA to acetyl-CoA. In the fatty acid biosynthesis MCD selectively removes malonyl-CoA and thus assures that methyl-malonyl-CoA is the only chain elongating substrate for fatty acid synthase and that fatty acids with multiple methyl side chains are produced. In peroxisomes it may be involved in degrading intraperoxisomal malonyl-CoA, which is generated by the peroxisomal beta-oxidation of odd chain-length dicarboxylic fatty acids. Plays a role in the metabolic balance between glucose and lipid oxidation in muscle independent of alterations in insulin signaling. May play a role in controlling the extent of ischemic injury by promoting glucose oxidation. Homotetramer. Dimer of dimers. The two subunits within a dimer display conformational differences suggesting that at any given moment, only one of the two subunits is competent for malonyl-CoA binding and catalytic activity. Under oxidizing conditions, can form disulfide-linked homotetramers (in vitro). Associates with the peroxisomal targeting signal receptor PEX5.

4F0X
CRYSTAL STRUCTURE OF HUMAN MALONYL-COA DECARBOXYLASE (PEROXISOMAL ISOFORM)
RCSB/PDB
Inspect Structure
See all 3D Structures for MLYCD

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
493ENSG00000103150ENST00000262430ENSP00000262430O95822-1
454O95822-2

Sub-cellular localization


UniProt: MLYCD is active in the following subcellular-locations: cytoplasm, mitochondrion matrix, peroxisome, peroxisome matrix.
GO terms: MLYCD is active in the following subcellular-locations: cytoplasm, cytosol, mitochondrial matrix, mitochondrion, peroxisomal matrix, peroxisome.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project MLYCD has gain in 0 cell-lines, loss in 1 cell-lines and no signal in 1003 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: COLO205, T47D, HCC_2998

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: Hs 746T, NCI-H322T, HEY

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: NHLF, HSMM, HMEC

(see details)

3D Structures


For MLYCD there are:
2 structures (10 chains) solved
1 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


MLYCD has been screened with 281 compounds (438 bioactivities), 190 compounds have bioactivities that show binding affinity of <= 500nM (312 bioactivities). (see details)