Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

RAB36 (O95755) - Overview - Molecular Target Synopsis

Protein


RAB36, Ras-related protein Rab-36
UniProt O95755

Also Known as RAB36_HUMAN, RAB36

Protein transport. Probably involved in vesicular traffic.

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: RAB36 is active in the following subcellular-locations: golgi apparatus membrane.
GO terms: RAB36 is active in the following subcellular-locations: Golgi apparatus, Golgi membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project RAB36 has gain in 7 cell-lines, loss in 3 cell-lines and no signal in 995 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: RPMI_8226, BT_549, MALME_3M

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: MOLP-2, KHM-1B, MM.1S

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, HMEC, HSMM

(see details)

3D Structures


At greater than 35% identity similarity to RAB36 there are:
109 structures (212 chains) solved
99 are solved in complex with at least one small molecule ligand
1 are solved with an approved drug

RAB36 is solved in complex with the approved drug(s):

AMP/ADENOSINE PHOSPHATE (3NKV_A, 3NKV_B).

(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


RAB36 has been screened with compounds ( bioactivities). (see details)