Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

RAB3D (O95716) - Overview - Molecular Target Synopsis

Protein


RAB3D, Ras-related protein Rab-3D
UniProt O95716

Also Known as RAB3D_HUMAN, RAB3D, GOV, RAB16

Protein transport. Probably involved in regulated exocytosis. Interacts with RIMS1, RIMS2, RPH3A, RPH3AL and RAB3IP.

2GF9
CRYSTAL STRUCTURE OF HUMAN RAB3D IN COMPLEX WITH GDP
RCSB/PDB
Inspect Structure
See all 3D Structures for RAB3D

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
219ENSG00000105514ENST00000589655, ENST00000222120ENSP00000466000, ENSP00000222120O95716-1

Sub-cellular localization


UniProt: RAB3D is active in the following subcellular-locations: cell membrane.
GO terms: RAB3D is active in the following subcellular-locations: azurophil granule membrane, cytoplasmic microtubule, endosome, extracellular exosome, plasma membrane, secretory vesicle, synaptic vesicle, vesicle, zymogen granule.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project RAB3D has gain in 1 cell-lines, loss in 0 cell-lines and no signal in 1004 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: MCF7, OVCAR_4, T47D

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: YMB-1, NCI-H810, NCI-H209

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: HMEC, NHEK, SK-N-SH

(see details)

3D Structures


For RAB3D there are:
1 structures (1 chains) solved
1 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


RAB3D has been screened with compounds ( bioactivities). (see details)